Molecular Characteristics
Complete Specifications
Structural Composition
Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-NH₂
Physical Properties
Thymosin Alpha-1 is a synthetic 28-amino-acid peptide originally isolated from thymic tissue. The peptide is N-terminally acetylated, which contributes to enhanced structural stability compared to non-acetylated analogs. Its mid-length chain provides moderate conformational stability while remaining susceptible to enzymatic degradation in biological environments. Lyophilized storage under cold, dry conditions is recommended. Protection from moisture, light exposure, and repeated freeze–thaw cycles helps preserve structural integrity and maintain analytical consistency during laboratory research applications.
Analysis & Documentation
Identity
Each production lot is checked against the reference structure recorded for this compound:
- Classification — Synthetic 28-amino-acid thymic peptide hormone
- Molecular formula — C₁₂₉H₂₁₅N₃₃O₅₅
- Expected mass — ~3,108.3 Da
- CAS registry — 62304-98-7
- Chain length — 28 amino acids (N-terminal acetylated)
- PubChem CID — Not available
Analytical Methods
Testing is carried out per lot by an independent laboratory. The methods measure what the material is and how much of it is the target compound:
- RP-HPLC — reverse-phase separation of the target from process-related impurities; purity is reported as area percent of the main peak
- Mass spectrometry — observed mass compared against the expected molecular mass above
- Retention time — compared against a reference standard run under the same conditions
- Chromatogram — reproduced on the certificate so the peak and any shoulders can be inspected directly
Material & Documentation
What arrives, and how to tie it back to its paperwork:
- Appearance as supplied — White to off-white lyophilized powder
- Solubility — Water, buffered aqueous solutions (e.g., PBS)
- Lot number — printed on the container label and used to look up the certificate
- Certificate — indexed by lot at Certificates of Analysis
Laboratory Handling and Storage Protocols
Lyophilized Powder Storage
- Store at –20°C to –80°C in the original, sealed vial
- Protect from light exposure and moisture
- A desiccated storage environment is recommended
- Stability data suggests extended stability when stored at −20 °C or below.
Reconstituted Solution Storage
- Short-term storage: Up to 7 days at 4°C
- Long-term storage: Store at –20°C in aliquots
- Use single-use aliquots to preserve peptide integrity
- Minimize freeze–thaw cycles; single-use aliquots are strongly recommended
Stability Characteristics
Thymosin Alpha-1 is a synthetic peptide research compound that demonstrates stable handling characteristics when managed according to standard peptide laboratory protocols. Proper cold storage of the lyophilized material, protection from light, careful reconstitution, and minimized freeze–thaw exposure help preserve structural integrity and solubility. When handled appropriately, Thymosin Alpha-1 supports consistent use in in vitro and analytical research applications.
Frequently Asked Questions
What is Thymosin Alpha-1?
Thymosin Alpha-1 is a synthetic 28–amino acid peptide modeled after a naturally occurring thymic peptide. It is used in research to investigate immune-related cellular signaling and regulatory mechanisms.
Is Thymosin Alpha-1 naturally occurring?
Yes. Thymosin Alpha-1 is derived from a naturally occurring peptide fragment found in the thymus. Synthetic research-grade versions replicate this endogenous sequence.
How does Thymosin Alpha-1 differ from Thymogen or other cytomedines?
Thymosin Alpha-1 is a defined 28–amino acid peptide sequence, whereas cytomedines such as Thymogen consist of shorter peptide fragments or complexes. Their structures and research applications differ significantly.
How is Thymosin Alpha-1 supplied?
Thymosin Alpha-1 is typically supplied as a lyophilized (freeze-dried) powder in sealed research vials to preserve stability during storage and shipment.
How should unreconstituted Thymosin Alpha-1 be stored?
Lyophilized Thymosin Alpha-1 should be stored:
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Long-term: −20 °C to −80 °C
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Short-term: 2–8 °C
Keep vials sealed and protected from light and moisture until use.
How should reconstituted Thymosin Alpha-1 be handled and stored?
Once reconstituted:
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Store at 2–8 °C for short-term laboratory use
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For extended storage, aliquot and freeze at −20 °C or below
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Minimize freeze–thaw cycles using single-use aliquots
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Gently swirl to mix; avoid vigorous agitation
Does Thymosin Alpha-1 require a Certificate of Analysis (COA)?
Yes. A Certificate of Analysis (COA) should be available for each batch of Thymosin Alpha-1, verifying identity, purity, and analytical testing results to ensure research quality and traceability.
Is Thymosin Alpha-1 FDA-approved?
Research-grade Thymosin Alpha-1 is not FDA-approved as a drug, supplement, or therapeutic product. It is sold exclusively as a research compound and must not be marketed or used for diagnostic, therapeutic, or consumption purposes.
Research Background
For a referenced overview of what the published research on this compound examines — and why it is unrelated to thymosin beta-4 despite the shared name — see What Is Thymosin Alpha-1? Research Background and Study Areas. It cites peer-reviewed sources and contains no dosing guidance.
This product is not for human consumption. It is sold strictly for research and educational purposes and is not intended to diagnose, treat, cure, or prevent any disease.
Any clinical data or research information referenced on this page is derived from peer-reviewed scientific literature and official publications. This information is provided for educational reference only and does not constitute medical advice or product claims.
By purchasing this product, you acknowledge that you are a qualified researcher and agree to use it in full compliance with all applicable laws and regulations.
