Molecular Characteristics
Complete Specifications
Structural Composition
His-D-2-Me-Trp-Ala-Trp-D-Phe-Lys-NH₂
Physical Properties
Hexarelin is a synthetic hexapeptide containing D-amino acid substitutions and a modified tryptophan residue (2-methyl-D-tryptophan), which enhance resistance to enzymatic degradation compared to peptides composed solely of L-amino acids. These structural modifications contribute to increased stability under controlled research conditions. Its short chain length supports efficient aqueous solubility and practical laboratory handling. Lyophilized storage and protection from moisture, light exposure, and repeated freeze–thaw cycles help preserve peptide integrity and maintain analytical consistency for research applications.
Analysis & Documentation
Identity
Each production lot is checked against the reference structure recorded for this compound:
- Classification — Synthetic hexapeptide (growth hormone–releasing peptide)
- Molecular formula — C₄₇H₅₈N₁₂O₆
- Expected mass — ~887.04 Da
- CAS registry — 140703-51-1
- Chain length — 6 amino acids
- PubChem CID — Not available
Analytical Methods
Testing is carried out per lot by an independent laboratory. The methods measure what the material is and how much of it is the target compound:
- RP-HPLC — reverse-phase separation of the target from process-related impurities; purity is reported as area percent of the main peak
- Mass spectrometry — observed mass compared against the expected molecular mass above
- Retention time — compared against a reference standard run under the same conditions
- Chromatogram — reproduced on the certificate so the peak and any shoulders can be inspected directly
Material & Documentation
What arrives, and how to tie it back to its paperwork:
- Appearance as supplied — White to off-white lyophilized powder
- Solubility — Water, phosphate-buffered saline (PBS)
- Lot number — printed on the container label and used to look up the certificate
- Certificate — indexed by lot at Certificates of Analysis
Laboratory Handling and Storage Protocols
Lyophilized Powder Storage
- Store at –20°C to –80°C in the original, sealed vial
- Protect from light exposure and moisture
- A desiccated storage environment is recommended
- Stability data suggests extended stability when stored at −20 °C or below.
Reconstituted Solution Storage
- Short-term storage: Up to 7 days at 4°C
- Long-term storage: Store at –20°C in aliquots
- Use single-use aliquots to preserve peptide integrity
- Minimize freeze–thaw cycles; single-use aliquots are strongly recommended
Stability Characteristics
Hexarelin is a synthetic peptide research compound that demonstrates stable handling characteristics when managed according to standard peptide laboratory protocols. Proper cold storage of the lyophilized material, careful reconstitution, and minimized freeze–thaw exposure help preserve structural integrity and solubility. When handled appropriately, Hexarelin supports consistent use in in vitro and analytical research applications.
Frequently Asked Questions
What is Hexarelin?
Hexarelin is a synthetic six–amino acid peptide designed to activate the GHS-R1a receptor in experimental models. It is commonly used in laboratory research exploring growth hormone–related signaling mechanisms.
How does Hexarelin differ from other GHRPs?
Hexarelin is structurally distinct from other growth hormone–releasing peptides such as GHRP-6 or GHRP-2. These structural differences may influence receptor affinity, signaling strength, and activity duration in comparative research models.
Is Hexarelin the same as GHRH analogs like CJC-1295?
No. Hexarelin primarily activates the ghrelin receptor (GHS-R1a), while GHRH analogs such as CJC-1295 act through the GHRH receptor. Although both are studied in growth hormone pathway research, their mechanisms of action differ.
How is Hexarelin supplied?
Hexarelin is typically supplied as a lyophilized (freeze-dried) powder in sealed research vials to maintain stability during storage and shipment.
How should unreconstituted Hexarelin be stored?
Lyophilized Hexarelin should be stored:
-
Long-term: −20 °C to −80 °C
-
Short-term: 2–8 °C
Keep vials sealed and protected from light and moisture until use.
How should reconstituted Hexarelin be handled and stored?
Once reconstituted:
-
Store at 2–8 °C for short-term laboratory use
-
For extended storage, aliquot and freeze at −20 °C or below
-
Minimize freeze–thaw cycles using single-use aliquots
-
Gently swirl to mix; avoid vigorous agitation
Does Hexarelin require a Certificate of Analysis (COA)?
Yes. A Certificate of Analysis (COA) should be available for each batch of Hexarelin, verifying identity, purity, and analytical testing results to support research quality and traceability.
Is Hexarelin FDA-approved?
No. Hexarelin is not FDA-approved as a drug, supplement, or therapeutic product. It is sold exclusively as a research compound and must not be marketed or used for diagnostic, therapeutic, or consumption purposes.
This product is not for human consumption. It is sold strictly for research and educational purposes and is not intended to diagnose, treat, cure, or prevent any disease.
Any clinical data or research information referenced on this page is derived from peer-reviewed scientific literature and official publications. This information is provided for educational reference only and does not constitute medical advice or product claims.
By purchasing this product, you acknowledge that you are a qualified researcher and agree to use it in full compliance with all applicable laws and regulations.
