Molecular Characteristics
Complete Specifications
Structural Composition
Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH₂
Physical Properties
Melanotan I is a synthetic linear peptide analog of alpha-melanocyte-stimulating hormone (α-MSH). Structural modifications including N-terminal acetylation, C-terminal amidation, and substitution of norleucine (Nle) enhance stability and resistance to enzymatic degradation under controlled research conditions. The presence of D-phenylalanine further contributes to structural persistence. Lyophilized storage and protection from moisture, light exposure, and repeated freeze–thaw cycles help preserve peptide integrity and maintain analytical consistency during laboratory applications.
Analysis & Documentation
Identity
Each production lot is checked against the reference structure recorded for this compound:
- Classification — Synthetic linear α-MSH analog (melanocortin receptor agonist peptide)
- Molecular formula — C₇₈H₁₁₁N₂₁O₁₉
- Expected mass — ~1,646.9 Da
- CAS registry — 75921-69-6
- Chain length — 13 amino acids (modified, N-terminal acetylated and C-terminal amidated)
- PubChem CID — Not available
Analytical Methods
Testing is carried out per lot by an independent laboratory. The methods measure what the material is and how much of it is the target compound:
- RP-HPLC — reverse-phase separation of the target from process-related impurities; purity is reported as area percent of the main peak
- Mass spectrometry — observed mass compared against the expected molecular mass above
- Retention time — compared against a reference standard run under the same conditions
- Chromatogram — reproduced on the certificate so the peak and any shoulders can be inspected directly
Material & Documentation
What arrives, and how to tie it back to its paperwork:
- Appearance as supplied — White to off-white lyophilized powder
- Solubility — Water, buffered aqueous solutions (e.g., PBS)
- Lot number — printed on the container label and used to look up the certificate
- Certificate — indexed by lot at Certificates of Analysis
Laboratory Handling and Storage Protocols
Lyophilized Powder Storage
- Store at –20°C to –80°C in the original, sealed vial
- Protect from light exposure and moisture
- A desiccated storage environment is recommended
- Stability data suggests extended stability when stored at −20 °C or below.
Reconstituted Solution Storage
- Short-term storage: Up to 7 days at 4°C
- Long-term storage: Store at –20°C in aliquots
- Use single-use aliquots to preserve peptide integrity
- Minimize freeze–thaw cycles; single-use aliquots are strongly recommended
Stability Characteristics
Melanotan I is a synthetic peptide research compound that demonstrates stable handling characteristics when managed according to standard peptide laboratory protocols. Proper cold storage of the lyophilized material, protection from light, careful reconstitution, and minimized freeze–thaw exposure help preserve structural integrity and solubility. When handled appropriately, Melanotan I supports consistent use in in vitro and analytical research applications.
Frequently Asked Questions
What is Melanotan I?
Melanotan I is a synthetic peptide analog of α-MSH designed to activate melanocortin receptors in experimental models. It is commonly used in research focused on pigmentation-related signaling pathways.
Is Melanotan I the same as Melanotan II?
No. Melanotan I and Melanotan II are structurally different peptides. While both interact with melanocortin receptors in research models, their receptor selectivity and signaling profiles differ.
Is Melanotan I a pharmaceutical product?
research-grade Melanotan I products are not pharmaceutical preparations and must not be marketed as approved medications.
How is Melanotan I supplied?
Melanotan I is typically supplied as a lyophilized (freeze-dried) powder in sealed research vials to maintain stability during storage and shipment.
How should unreconstituted Melanotan I be stored?
Lyophilized Melanotan I should be stored:
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Long-term: −20 °C to −80 °C
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Short-term: 2–8 °C
Keep vials sealed and protected from light and moisture until use.
How should reconstituted Melanotan I be handled and stored?
Once reconstituted:
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Store at 2–8 °C for short-term laboratory use
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For extended storage, aliquot and freeze at −20 °C or below
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Minimize freeze–thaw cycles using single-use aliquots
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Gently swirl to mix; avoid vigorous agitation
Does Melanotan I require a Certificate of Analysis (COA)?
Yes. A Certificate of Analysis (COA) should be available for each batch of Melanotan I, verifying identity and purity to ensure research quality and traceability.
Is Melanotan I FDA-approved?
Research-grade Melanotan I is not FDA-approved as a drug, supplement, or therapeutic product. It is sold exclusively as a research compound and must not be marketed or used for diagnostic, therapeutic, or consumption purposes.
This product is not for human consumption. It is sold strictly for research and educational purposes and is not intended to diagnose, treat, cure, or prevent any disease.
Any clinical data or research information referenced on this page is derived from peer-reviewed scientific literature and official publications. This information is provided for educational reference only and does not constitute medical advice or product claims.
By purchasing this product, you acknowledge that you are a qualified researcher and agree to use it in full compliance with all applicable laws and regulations.
