Molecular Characteristics
Complete Specifications
Structural Composition
44-amino-acid synthetic analog of human growth hormone–releasing hormone (GHRH) with targeted amino acid substitutions for enhanced stability
Physical Properties
Tesamorelin is a synthetic 44-amino-acid analog of growth hormone–releasing hormone (GHRH) engineered with targeted amino acid substitutions to enhance resistance to enzymatic degradation under research conditions. Its extended peptide chain and structural modifications provide improved stability compared to shorter GHRH fragments. As with other long-chain peptides, lyophilized storage under cold, dry conditions is recommended. Protection from moisture, light exposure, and repeated freeze–thaw cycles helps preserve structural integrity and maintain analytical consistency during laboratory applications.
Analysis & Documentation
Identity
Each production lot is checked against the reference structure recorded for this compound:
- Classification — Synthetic 44-amino-acid growth hormone–releasing hormone (GHRH) analog
- Molecular formula — C₂₂₁H₃₆₆N₇₂O₆₇
- Expected mass — ~5,135.9 Da
- CAS registry — 218949-48-5
- Chain length — 44 amino acids (modified)
- PubChem CID — Not available
Analytical Methods
Testing is carried out per lot by an independent laboratory. The methods measure what the material is and how much of it is the target compound:
- RP-HPLC — reverse-phase separation of the target from process-related impurities; purity is reported as area percent of the main peak
- Mass spectrometry — observed mass compared against the expected molecular mass above
- Retention time — compared against a reference standard run under the same conditions
- Chromatogram — reproduced on the certificate so the peak and any shoulders can be inspected directly
Material & Documentation
What arrives, and how to tie it back to its paperwork:
- Appearance as supplied — White to off-white lyophilized powder
- Solubility — Water, buffered aqueous solutions (e.g., PBS)
- Lot number — printed on the container label and used to look up the certificate
- Certificate — indexed by lot at Certificates of Analysis
Laboratory Handling and Storage Protocols
Lyophilized Powder Storage
- Store at –20°C to –80°C in the original, sealed vial
- Protect from light exposure and moisture
- A desiccated storage environment is recommended
- Stability data suggests extended stability when stored at −20 °C or below.
Reconstituted Solution Storage
- Short-term storage: Up to 7 days at 4°C
- Long-term storage: Store at –20°C in aliquots
- Use single-use aliquots to preserve peptide integrity
- Minimize freeze–thaw cycles; single-use aliquots are strongly recommended
Stability Characteristics
Tesamorelin is a synthetic peptide research compound that demonstrates stable handling characteristics when managed according to standard peptide laboratory protocols. Proper cold storage of the lyophilized material, protection from light, careful reconstitution, and minimized freeze–thaw exposure help preserve structural integrity and solubility. When handled appropriately, Tesamorelin supports consistent use in in vitro and analytical research applications.
Frequently Asked Questions
What is Tesamorelin?
Tesamorelin is a synthetic peptide analog of GHRH designed to activate the GHRH receptor in experimental models. It is used in research investigating endocrine signaling and growth hormone regulatory mechanisms.
How does Tesamorelin differ from CJC-1295?
Both are GHRH analogs studied in endocrine research, but they differ structurally and in stability characteristics. CJC-1295 may be available in DAC and non-DAC forms, which can influence activity duration in experimental models, whereas Tesamorelin has its own distinct sequence and pharmacological profile.
Is Tesamorelin the same as growth hormone (GH)?
No. Tesamorelin is a GHRH analog studied at the GHRH receptor. It is not growth hormone itself.
How is Tesamorelin supplied?
Tesamorelin is typically supplied as a lyophilized (freeze-dried) powder in sealed research vials to preserve stability during storage and shipment.
How should unreconstituted Tesamorelin be stored?
Lyophilized Tesamorelin should be stored:
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Long-term: −20 °C to −80 °C
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Short-term: 2–8 °C
Keep vials sealed and protected from light and moisture until use.
How should reconstituted Tesamorelin be handled and stored?
Once reconstituted:
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Store at 2–8 °C for short-term laboratory use
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For extended storage, aliquot and freeze at −20 °C or below
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Minimize freeze–thaw cycles using single-use aliquots
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Gently swirl to mix; avoid vigorous agitation
Does Tesamorelin require a Certificate of Analysis (COA)?
Yes. A Certificate of Analysis (COA) should be available for each batch of Tesamorelin, verifying identity, purity, and analytical testing results to ensure research quality and traceability.
Is Tesamorelin FDA-approved?
Research-grade Tesamorelin is not FDA-approved as a drug, supplement, or therapeutic product. It is sold exclusively as a research compound and must not be marketed or used for diagnostic, therapeutic, or consumption purposes.
Research Background
For a referenced overview of the published research, the approved-drug context, and why this research material is not the approved medicine, see What Is Tesamorelin? Research Background and Approved-Drug Context. It cites peer-reviewed sources and contains no dosing guidance.
This product is not for human consumption. It is sold strictly for research and educational purposes and is not intended to diagnose, treat, cure, or prevent any disease.
Any clinical data or research information referenced on this page is derived from peer-reviewed scientific literature and official publications. This information is provided for educational reference only and does not constitute medical advice or product claims.
By purchasing this product, you acknowledge that you are a qualified researcher and agree to use it in full compliance with all applicable laws and regulations.
