Molecular Characteristics
Complete Specifications
Structural Composition
Modified 29-amino-acid GRF (1–29) sequence with substitutions at positions 2, 8, 15, and 27 to enhance stability
Physical Properties
CJC-1295 (No DAC) is a modified 29-amino-acid peptide derived from growth hormone–releasing factor (GRF 1–29). Targeted amino acid substitutions enhance resistance to enzymatic degradation while preserving the core structural framework. Unlike DAC-conjugated versions, this variant does not include a drug affinity complex moiety, resulting in a shorter structural persistence profile under research conditions. Lyophilized presentation supports stability during storage, and protection from moisture, light, and repeated freeze–thaw cycles helps maintain peptide integrity for laboratory and analytical applications.
Analysis & Documentation
Identity
Each production lot is checked against the reference structure recorded for this compound:
- Classification — Synthetic growth hormone–releasing factor (GRF 1–29) analog
- Molecular formula — C₁₅₂H₂₅₂N₄₄O₄₂
- Expected mass — ~3,367.9 Da
- CAS registry — Not assigned (modified GRF analog)
- Chain length — 29 amino acids (modified)
- PubChem CID — Not available
Analytical Methods
Testing is carried out per lot by an independent laboratory. The methods measure what the material is and how much of it is the target compound:
- RP-HPLC — reverse-phase separation of the target from process-related impurities; purity is reported as area percent of the main peak
- Mass spectrometry — observed mass compared against the expected molecular mass above
- Retention time — compared against a reference standard run under the same conditions
- Chromatogram — reproduced on the certificate so the peak and any shoulders can be inspected directly
Material & Documentation
What arrives, and how to tie it back to its paperwork:
- Appearance as supplied — White to off-white lyophilized powder
- Solubility — Water, phosphate-buffered saline (PBS)
- Lot number — printed on the container label and used to look up the certificate
- Certificate — indexed by lot at Certificates of Analysis
Laboratory Handling and Storage Protocols
Lyophilized Powder Storage
- Store at –20°C to –80°C in the original, sealed vial
- Protect from light exposure and moisture
- A desiccated storage environment is recommended
- Stability data suggests extended stability when stored at −20 °C or below.
Reconstituted Solution Storage
- Short-term storage: Up to 7 days at 4°C
- Long-term storage: Store at –20°C in aliquots
- Use single-use aliquots to preserve peptide integrity
- Minimize freeze–thaw cycles; single-use aliquots are strongly recommended
Stability Characteristics
CJC-1295 (No DAC) is a synthetic peptide research compound that demonstrates stable handling characteristics when managed according to standard peptide laboratory protocols. Proper cold storage of the lyophilized material, careful reconstitution, and minimized freeze–thaw exposure help preserve structural integrity and solubility. When handled appropriately, CJC-1295 (No DAC) supports consistent use in in vitro and analytical research applications.
Frequently Asked Questions
What is CJC-1295 (No DAC)?
CJC-1295 (No DAC) is a modified GHRH analog studied in laboratory settings for its ability to activate GHRH receptors and influence downstream growth hormone signaling pathways in preclinical research models.
What does “No DAC” mean?
“No DAC” indicates that the peptide does not include the Drug Affinity Complex modification that extends half-life in research models. As a result, CJC-1295 (No DAC) typically demonstrates a shorter duration of activity compared to CJC-1295 with DAC.
How does CJC-1295 (No DAC) differ from CJC-1295 with DAC?
The primary difference is the presence of the Drug Affinity Complex (DAC) in the extended version. The DAC modification allows binding to serum albumin in research models, extending circulation time. The No DAC version lacks this modification and therefore has a shorter activity window in comparative studies.
How is CJC-1295 (No DAC) supplied?
CJC-1295 (No DAC) is typically supplied as a lyophilized (freeze-dried) powder in sealed research vials to maintain stability during storage and shipment.
How should unreconstituted CJC-1295 (No DAC) be stored?
Lyophilized peptide should be stored:
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Long-term: −20 °C to −80 °C
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Short-term: 2–8 °C
Keep vials sealed and protected from light and moisture.
How should reconstituted CJC-1295 (No DAC) be handled and stored?
Once reconstituted:
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Store at 2–8 °C for short-term laboratory use
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For longer-term storage, aliquot and freeze at −20 °C or below
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Minimize freeze–thaw cycles using single-use aliquots
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Gently swirl to mix; avoid vigorous agitation
Is CJC-1295 (No DAC) FDA-approved?
No. CJC-1295 (No DAC) is not FDA-approved as a drug, supplement, or therapeutic product. It is sold exclusively as a research compound and must not be marketed or used for diagnostic, therapeutic, or consumption purposes.
Does CJC-1295 (No DAC) require a Certificate of Analysis (COA)?
Yes. A Certificate of Analysis (COA) should be available for each batch, confirming peptide identity, purity, and analytical testing results to support research quality and traceability.
Research Background
For a referenced overview of what the published research examines — including why the human trials used only the DAC form, and what the literature does not establish — see What Is CJC-1295? Research Background, and DAC vs No DAC. It cites peer-reviewed sources and contains no dosing guidance.
This product is not for human consumption. It is sold strictly for research and educational purposes and is not intended to diagnose, treat, cure, or prevent any disease.
Any clinical data or research information referenced on this page is derived from peer-reviewed scientific literature and official publications. This information is provided for educational reference only and does not constitute medical advice or product claims.
By purchasing this product, you acknowledge that you are a qualified researcher and agree to use it in full compliance with all applicable laws and regulations.
