Molecular Characteristics
Complete Specifications
Structural Composition
Modified 37-amino-acid human amylin analog with acylation and strategic substitutions to enhance stability and receptor interaction
Physical Properties
Cagrilintide is a synthetic 37-amino-acid peptide engineered as a long-acting amylin analog. Structural modifications, including targeted amino acid substitutions and lipidation (acylation), enhance molecular stability and extend structural persistence under controlled research conditions. The presence of disulfide linkages contributes to conformational stability, while lyophilized formulation supports extended shelf stability when protected from light, moisture, and repeated freeze–thaw cycles. Proper cold storage preserves peptide integrity for laboratory and analytical applications.
Analysis & Documentation
Identity
Each production lot is checked against the reference structure recorded for this compound:
- Classification — Synthetic long-acting amylin analog
- Molecular formula — C₂₀₀H₃₁₂N₅₆O₆₃S₂
- Expected mass — ~4,263.9 Da
- CAS registry — 1415456-99-3
- Chain length — 37 amino acids (modified)
- PubChem CID — Not available
Analytical Methods
Testing is carried out per lot by an independent laboratory. The methods measure what the material is and how much of it is the target compound:
- RP-HPLC — reverse-phase separation of the target from process-related impurities; purity is reported as area percent of the main peak
- Mass spectrometry — observed mass compared against the expected molecular mass above
- Retention time — compared against a reference standard run under the same conditions
- Chromatogram — reproduced on the certificate so the peak and any shoulders can be inspected directly
Material & Documentation
What arrives, and how to tie it back to its paperwork:
- Appearance as supplied — White to off-white lyophilized powder
- Solubility — Water, phosphate-buffered saline (PBS)
- Lot number — printed on the container label and used to look up the certificate
- Certificate — indexed by lot at Certificates of Analysis
Laboratory Handling and Storage Protocols
Lyophilized Powder Storage
- Store at –20°C to –80°C in the original, sealed vial
- Protect from light exposure and moisture
- A desiccated storage environment is recommended
- Stability data suggests extended stability when stored at −20 °C or below.
Reconstituted Solution Storage
- Short-term storage: Up to 7 days at 4°C
- Long-term storage: Store at –20°C in aliquots
- Use single-use aliquots to preserve peptide integrity
- Minimize freeze–thaw cycles; single-use aliquots are strongly recommended
Stability Characteristics
Cagrilintide is a synthetic peptide research compound that demonstrates good stability under controlled laboratory conditions. Maintaining appropriate cold storage of the lyophilized material, minimizing mechanical agitation during reconstitution, and limiting freeze–thaw exposure help preserve structural integrity and solubility. When handled according to standard peptide protocols, Cagrilintide supports consistent use in in vitro and analytical research applications.
Frequently Asked Questions
What is Cagrilintide?
Cagrilintide is a synthetic amylin receptor agonist engineered for extended activity in experimental models. It is supplied as a lyophilized powder for laboratory use, with identity and purity reported per lot on the Certificate of Analysis.
How does Cagrilintide differ from native amylin?
Cagrilintide is structurally modified to provide enhanced stability and extended activity compared to native amylin in research models. These modifications may influence receptor affinity and pharmacokinetic behavior in preclinical studies.
Is Cagrilintide the same as GLP-1 receptor agonists?
No. Cagrilintide primarily targets amylin and calcitonin receptor pathways, whereas GLP-1 receptor agonists act on the GLP-1 receptor. While both are studied in metabolic research, their mechanisms of action differ.
How is Cagrilintide supplied?
Cagrilintide is typically supplied as a lyophilized (freeze-dried) powder in sealed research vials. This form supports stability during storage and transport prior to laboratory preparation.
How should unreconstituted Cagrilintide be stored?
Lyophilized Cagrilintide should be stored:
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Long-term: −20 °C to −80 °C
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Short-term: 2–8 °C
Vials should remain sealed and protected from light and moisture.
How should reconstituted Cagrilintide be handled and stored?
Once reconstituted:
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Store at 2–8 °C for short-term laboratory use
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For extended storage, aliquot and freeze at −20 °C or below
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Minimize freeze–thaw cycles using single-use aliquots
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Gently swirl to mix; avoid vigorous agitation
Is Cagrilintide FDA-approved?
Cagrilintide is not FDA-approved as a research compound for human consumption. When sold for laboratory use, it must not be marketed or used for diagnostic, therapeutic, or consumption purposes.
Does Cagrilintide require a Certificate of Analysis (COA)?
Yes. A Certificate of Analysis (COA) should be available for each batch of Cagrilintide, verifying identity, purity, and analytical testing results to ensure research quality and traceability.
This product is not for human consumption. It is sold strictly for research and educational purposes and is not intended to diagnose, treat, cure, or prevent any disease.
Any clinical data or research information referenced on this page is derived from peer-reviewed scientific literature and official publications. This information is provided for educational reference only and does not constitute medical advice or product claims.
By purchasing this product, you acknowledge that you are a qualified researcher and agree to use it in full compliance with all applicable laws and regulations.
