For laboratory research use only. Not for human or veterinary use. This is educational reference information, not medical advice.
Research Database / Peptides / Thymosin Alpha-1
Thymosin Alpha-1 · Thymosin Alpha-1 (Thymalfasin)

Thymosin Alpha-1

Thymic Peptides
Overview Research Publications Laboratory FAQ References
Overview
Scientific nameThymosin Alpha-1 (Thymalfasin)
AbbreviationThymosin Alpha-1
CAS Number62304-98-7
Molecular formulaC129H215N33O55
Molecular weight3108.3 g/mol (average)
Sequence (one-letter)SDAAVDTSSEITTKDLKEKKEVVEEAEN
Length28 residues
PubChem CID16130571
2D / 3D structure
2D chemical structure of Thymosin Alpha-1

Interactive sequence

Select a residue to see its amino acid.
Research Summary

Mechanisms under investigation

The following are areas of ongoing preclinical investigation. They describe hypotheses and observations reported in the literature, not established clinical effects.

Evidence tiers below reflect how much has been studied in each model type. Counts describe research volume — they do not indicate proven efficacy, safety, or clinical consensus.

Evidence base (transparent counts)

Cellular studies 2 publications
Animal studies 2 publications
Human observational reports 0 publications
Controlled human trials 0 publications
Review articles 2 publications
Publication Library

Selected literature

Filter by study model. Each record is classified for the evidence base above.

2024
Phenotypic drug discovery perspective on thymosin alpha-1 therapeutic utilityReview · PubMed (38903817)
2020
Protects against CTLA-4 intestinal immunopathology in murine modelsAnimal · mouse · PubMed (32817121)
2020
Comprehensive review of thymosin alpha-1 immunomodulatory literatureReview · PubMed (33362999)
2010
Immunomodulatory and host-defense effects in preclinical infection modelsAnimal · mouse · PubMed (20699109)
2007
In vitro study measuring dendritic cell differentiation and maturation markers in human monocyte cultures exposed to thymosin alpha-1.Cellular · cell culture · PubMed (17532057)
2004
Modulates murine bone marrow-derived dendritic cell maturation and functionCellular · cell culture · PubMed (15099531)

Each record maps to a structured evidence row with study model, species, and support level.

Laboratory Information

Handling and reference

Molecular weight calculator

Average-mass estimate from a one-letter sequence.

Reconstitution calculator

Laboratory concentration only. Not dosing guidance.

Frequently Asked Questions
What is Thymosin Alpha-1?
Thymosin Alpha-1 is a research compound; the identity and structure data shown here are compiled from public chemical databases (primarily PubChem). For laboratory research use only.
What research models has it been studied in?
The literature indexed here is predominantly cellular (in vitro) and animal studies. See the evidence base and publication library above for the transparent counts by study model.
Is there controlled human clinical trial evidence?
Controlled human clinical trials are counted separately in the evidence base above. Cellular and animal findings do not establish human clinical effects.
How is it stored and handled in a laboratory?
Refer to the laboratory information section above.
Is this intended for human use?
No. All information and materials are for laboratory research use only — not for human or veterinary use, and not intended to diagnose, treat, cure, or prevent any disease.
Documentation

Research material & documentation

This profile is an educational reference. Lot-level laboratory documentation for materials supplied by Peptide Titans is published openly.

Thymosin Alpha-1 research material →  ·  Lot-specific Certificates of Analysis →  ·  How lots are tested →

References and Citation

Evidence records

  1. Phenotypic drug discovery perspective on thymosin alpha-1 therapeutic utility (2024) — review — PubMed.
  2. Protects against CTLA-4 intestinal immunopathology in murine models (2020) — in vivo — PubMed.
  3. Comprehensive review of thymosin alpha-1 immunomodulatory literature (2020) — review — PubMed.
  4. Immunomodulatory and host-defense effects in preclinical infection models (2010) — in vivo — PubMed.
  5. In vitro study measuring dendritic cell differentiation and maturation markers in human monocyte cultures exposed to thymosin alpha-1. (2007) — in vitro — PubMed.
  6. Modulates murine bone marrow-derived dendritic cell maturation and function (2004) — in vitro — PubMed.

Every record carries a study model, species, support level and review status in the evidence table.

Citation generator

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For laboratory research use only. Not for human or veterinary use. Educational reference information — not medical advice.