Molecular Characteristics
Complete Specifications
Structural Composition
Lys-Pro-Val (KPV)
Physical Properties
KPV is a short synthetic tripeptide corresponding to a fragment of alpha-melanocyte-stimulating hormone (α-MSH). Its minimal three-amino-acid structure supports strong aqueous solubility and straightforward laboratory handling. Due to its small size, the peptide exhibits predictable stability characteristics when stored in lyophilized form. Protection from moisture, light exposure, and repeated freeze–thaw cycles helps maintain structural integrity and analytical consistency during research applications.
Analysis & Documentation
Identity
Each production lot is checked against the reference structure recorded for this compound:
- Classification — Synthetic tripeptide (α-MSH fragment)
- Molecular formula — C₁₆H₃₀N₄O₄
- Expected mass — ~342.44 Da
- CAS registry — Not assigned (synthetic tripeptide)
- Chain length — 3 amino acids
- PubChem CID — Not available
Analytical Methods
Testing is carried out per lot by an independent laboratory. The methods measure what the material is and how much of it is the target compound:
- RP-HPLC — reverse-phase separation of the target from process-related impurities; purity is reported as area percent of the main peak
- Mass spectrometry — observed mass compared against the expected molecular mass above
- Retention time — compared against a reference standard run under the same conditions
- Chromatogram — reproduced on the certificate so the peak and any shoulders can be inspected directly
Material & Documentation
What arrives, and how to tie it back to its paperwork:
- Appearance as supplied — White to off-white lyophilized powder
- Solubility — Water, buffered aqueous solutions (e.g., PBS)
- Lot number — printed on the container label and used to look up the certificate
- Certificate — indexed by lot at Certificates of Analysis
Laboratory Handling and Storage Protocols
Lyophilized Powder Storage
- Store at –20°C to –80°C in the original, sealed vial
- Protect from light exposure and moisture
- A desiccated storage environment is recommended
- Stability data suggests extended stability when stored at −20 °C or below.
Reconstituted Solution Storage
- Short-term storage: Up to 7 days at 4°C
- Long-term storage: Store at –20°C in aliquots
- Use single-use aliquots to preserve peptide integrity
- Minimize freeze–thaw cycles; single-use aliquots are strongly recommended
Stability Characteristics
KPV is a synthetic tripeptide research compound that demonstrates stable handling characteristics when managed according to standard peptide laboratory protocols. Proper cold storage of the lyophilized material, careful reconstitution, and minimized freeze–thaw exposure help maintain structural integrity and solubility. When handled appropriately, KPV supports consistent use in in vitro and analytical research applications.
Frequently Asked Questions
What is KPV?
KPV is a short-chain tripeptide consisting of the amino acids lysine, proline, and valine. It represents a biologically active fragment of α-MSH and is used in research investigating inflammatory pathway signaling.
Is KPV the same as α-MSH?
No. KPV is a fragment of α-MSH, not the full peptide. It contains a specific three–amino acid sequence believed to retain certain signaling properties in experimental models.
Is KPV a naturally occurring peptide?
The KPV sequence is derived from a naturally occurring hormone (α-MSH). Synthetic KPV used in research is manufactured to replicate this specific tripeptide fragment.
How is KPV supplied?
KPV is typically supplied as a lyophilized (freeze-dried) powder in sealed research vials to maintain stability during storage and shipment.
How should unreconstituted KPV be stored?
Lyophilized KPV should be stored:
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Long-term: −20 °C to −80 °C
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Short-term: 2–8 °C
Keep vials sealed and protected from light and moisture until use.
How should reconstituted KPV be handled and stored?
Once reconstituted:
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Store at 2–8 °C for short-term laboratory use
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For extended storage, aliquot and freeze at −20 °C or below
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Minimize freeze–thaw cycles using single-use aliquots
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Gently swirl to mix; avoid vigorous agitation
Does KPV require a Certificate of Analysis (COA)?
Yes. A Certificate of Analysis (COA) should be available for each batch of KPV, verifying identity and purity to ensure research quality and traceability.
Is KPV FDA-approved?
No. KPV is not FDA-approved as a drug, supplement, or therapeutic product. It is sold exclusively as a research compound and must not be marketed or used for diagnostic, therapeutic, or consumption purposes.
Research Background
For a referenced overview of what the published research on this compound examines, its regulatory status, and what the literature does not establish, see What Is KPV Peptide? Research Background and Study Areas. It cites peer-reviewed sources and contains no dosing guidance.
This product is not for human consumption. It is sold strictly for research and educational purposes and is not intended to diagnose, treat, cure, or prevent any disease.
Any clinical data or research information referenced on this page is derived from peer-reviewed scientific literature and official publications. This information is provided for educational reference only and does not constitute medical advice or product claims.
By purchasing this product, you acknowledge that you are a qualified researcher and agree to use it in full compliance with all applicable laws and regulations.
