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Research Database / Peptides / KPV
KPV · Lysine-Proline-Valine (KPV)

KPV

Peptide Fragments
Overview Research Publications Laboratory FAQ References
Overview
Scientific nameLysine-Proline-Valine (KPV)
Synonymsalpha-MSH (11-13)
AbbreviationKPV
CAS Number67727-97-3
Molecular formulaC16H30N4O4
Molecular weight342.43 g/mol (average)
Sequence (one-letter)KPV
Length3 residues
PubChem CID125672
2D / 3D structure
2D chemical structure of KPV

Interactive sequence

Select a residue to see its amino acid.
Research Summary

Mechanisms under investigation

The following are areas of ongoing preclinical investigation. They describe hypotheses and observations reported in the literature, not established clinical effects.

Evidence tiers below reflect how much has been studied in each model type. Counts describe research volume — they do not indicate proven efficacy, safety, or clinical consensus.

Evidence base (transparent counts)

Cellular studies 2 publications
Animal studies 0 publications
Human observational reports 0 publications
Controlled human trials 0 publications
Review articles 2 publications
Publication Library

Selected literature

Filter by study model. Each record is classified for the evidence base above.

2010
Review article on alpha-melanocyte-stimulating hormone (alpha-MSH) and its C-terminal tripeptide KPV.Review · PubMed (21222263)
2004
Examined signalling responses to alpha-MSH, the MSH 11-13 (KPV) fragment and ACTH in cultured human keratinocytes.Cellular · human · PubMed (15102092)
2003
Comparative study of KPV, alpha-MSH and core melanocortin peptides in a mouse model and in cultured macrophages, measuring leukocyte accumulation, cytokine release and cyclic AMP.Cellular · PubMed (12750433)
2000
Review article on alpha-MSH, covering the C-terminal KPV sequence.Review · PubMed (11268347)

Each record maps to a structured evidence row with study model, species, and support level.

Laboratory Information

Handling and reference

Molecular weight calculator

Average-mass estimate from a one-letter sequence.

Frequently Asked Questions
What is KPV?
KPV is a research compound; the identity and structure data shown here are compiled from public chemical databases (primarily PubChem). For laboratory research use only.
What research models has it been studied in?
The literature indexed here is predominantly cellular (in vitro) and animal studies. See the evidence base and publication library above for the transparent counts by study model.
Is there controlled human clinical trial evidence?
Controlled human clinical trials are counted separately in the evidence base above. Cellular and animal findings do not establish human clinical effects.
How is it stored and handled in a laboratory?
Refer to the laboratory information section above.
Is this intended for human use?
No. All information and materials are for laboratory research use only — not for human or veterinary use, and not intended to diagnose, treat, cure, or prevent any disease.
Documentation

Research material & documentation

This profile is an educational reference. Lot-level laboratory documentation for materials supplied by Peptide Titans is published openly.

KPV research material →  ·  Lot-specific Certificates of Analysis →  ·  How lots are tested →

References and Citation

Evidence records

  1. Review article on alpha-melanocyte-stimulating hormone (alpha-MSH) and its C-terminal tripeptide KPV. (2010) — review — PubMed.
  2. Examined signalling responses to alpha-MSH, the MSH 11-13 (KPV) fragment and ACTH in cultured human keratinocytes. (2004) — in vitro — PubMed.
  3. Comparative study of KPV, alpha-MSH and core melanocortin peptides in a mouse model and in cultured macrophages, measuring leukocyte accumulation, cytokine release and cyclic AMP. (2003) — in vitro — PubMed.
  4. Review article on alpha-MSH, covering the C-terminal KPV sequence. (2000) — review — PubMed.

Every record carries a study model, species, support level and review status in the evidence table. Terms used throughout these profiles are defined in the peptide research glossary.

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For laboratory research use only. Not for human or veterinary use. Educational reference information — not medical advice.