For laboratory research use only. Not for human or veterinary use. This is educational reference information, not medical advice.
KPV · Lysine-Proline-Valine (KPV)
KPV
Peptide Fragments
| Scientific name | Lysine-Proline-Valine (KPV) |
|---|---|
| Synonyms | alpha-MSH (11-13) |
| Abbreviation | KPV |
| CAS Number | 67727-97-3 |
| Molecular formula | C16H30N4O4 |
| Molecular weight | 342.43 g/mol (average) |
| Sequence (one-letter) | KPV |
| Length | 3 residues |
| PubChem CID | 125672 |
2D / 3D structure
![2D chemical structure of KPV]()
Interactive sequence
Select a residue to see its amino acid.
Mechanisms under investigation
The following are areas of ongoing preclinical investigation. They describe hypotheses and observations reported in the literature, not established clinical effects.
Evidence tiers below reflect how much has been studied in each model type. Counts describe research volume — they do not indicate proven efficacy, safety, or clinical consensus.
Evidence base (transparent counts)
Cellular studies
2 publications
Animal studies
2 publications
Human observational reports
0 publications
Controlled human trials
0 publications
Review articles
2 publications
Selected literature
Filter by study model. Each record is classified for the evidence base above.
2021
Tested a mucoadhesive hydrogel carrying tripeptide KPV in a rat model of chemotherapy-induced oral mucositis, reporting inflammatory, antibacterial and tissue-morphology endpoints.Animal · rat · PubMed (34846053)
2010
Review of anti-inflammatory activity reported for alpha-melanocyte-stimulating hormone C-terminal fragments, including the tripeptide KPV.Review · PubMed (21222263)
2008
Evaluated the melanocortin-derived tripeptide KPV in murine models of inflammatory bowel disease, reporting inflammatory endpoints.Animal · mouse · PubMed (18092346)
2004
Examined signalling responses to alpha-MSH, the MSH 11-13 (KPV) fragment and ACTH in cultured human keratinocytes.Cellular · human · PubMed (15102092)
2003
Comparative study dissecting the contributions of the core and C-terminal KPV fragments of alpha-MSH to measured anti-inflammatory responses.Cellular · PubMed (12750433)
2000
Review of alpha-MSH neuroimmunomodulatory signaling, covering the C-terminal KPV sequence as the region associated with anti-inflammatory activity.Review · PubMed (11268347)
Each record maps to a structured evidence row with study model, species, and support level.
Handling and reference
Molecular weight calculator
Average-mass estimate from a one-letter sequence.
Reconstitution calculator
Laboratory concentration only. Not dosing guidance.
What is KPV?
KPV is a research compound; the identity and structure data shown here are compiled from public chemical databases (primarily PubChem). For laboratory research use only.
What research models has it been studied in?
The literature indexed here is predominantly cellular (in vitro) and animal studies. See the evidence base and publication library above for the transparent counts by study model.
Is there controlled human clinical trial evidence?
Controlled human clinical trials are counted separately in the evidence base above. Cellular and animal findings do not establish human clinical effects.
How is it stored and handled in a laboratory?
Refer to the laboratory information section above.
Is this intended for human use?
No. All information and materials are for laboratory research use only — not for human or veterinary use, and not intended to diagnose, treat, cure, or prevent any disease.
Research material & documentation
This profile is an educational reference. Lot-level laboratory documentation for materials supplied by Peptide Titans is published openly.
KPV research material → · Lot-specific Certificates of Analysis → · How lots are tested →
Evidence records
- Tested a mucoadhesive hydrogel carrying tripeptide KPV in a rat model of chemotherapy-induced oral mucositis, reporting inflammatory, antibacterial and tissue-morphology endpoints. (2021) — in vivo — PubMed.
- Review of anti-inflammatory activity reported for alpha-melanocyte-stimulating hormone C-terminal fragments, including the tripeptide KPV. (2010) — review — PubMed.
- Evaluated the melanocortin-derived tripeptide KPV in murine models of inflammatory bowel disease, reporting inflammatory endpoints. (2008) — in vivo — PubMed.
- Examined signalling responses to alpha-MSH, the MSH 11-13 (KPV) fragment and ACTH in cultured human keratinocytes. (2004) — in vitro — PubMed.
- Comparative study dissecting the contributions of the core and C-terminal KPV fragments of alpha-MSH to measured anti-inflammatory responses. (2003) — in vitro — PubMed.
- Review of alpha-MSH neuroimmunomodulatory signaling, covering the C-terminal KPV sequence as the region associated with anti-inflammatory activity. (2000) — review — PubMed.
Every record carries a study model, species, support level and review status in the evidence table.
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For laboratory research use only. Not for human or veterinary use. Educational reference information — not medical advice.