Molecular Characteristics
Complete Specifications
Structural Composition
5-Amino-1-methylquinolinium iodide, consisting of a quaternary quinoline ring substituted with an amino group and paired with an iodide counterion
Physical Properties
5-Amino-1MQ is a low-molecular-weight quaternary ammonium compound featuring a positively charged quinolinium core. The permanent cationic charge enhances aqueous solubility and contributes to chemical stability under controlled laboratory conditions. The iodide counterion stabilizes the salt form, while the aromatic ring system provides structural rigidity. Due to its non-peptide nature, the compound is not subject to enzymatic peptide degradation and demonstrates favorable shelf stability when stored in a dry, light-protected environment.
Research Applications
Metabolic and Cellular Regulation Research
5-Amino-1MQ is primarily utilized as a research compound in studies examining cellular metabolism and enzymatic regulation. Laboratory investigations focus on its role in:
- NNMT Inhibition Models: Investigation of nicotinamide N-methyltransferase (NNMT) activity and its influence on cellular metabolic pathways
- NAD+ Metabolism Research: Analysis of nicotinamide utilization, methylation balance, and cellular energy regulation
- Cellular Energy Homeostasis: Examination of mitochondrial efficiency, ATP production, and metabolic flux under experimental conditions
- Adipocyte Function Studies: Research into adipose cell differentiation, lipid metabolism, and energy storage mechanisms
- Epigenetic and Methylation Pathways: Investigation of methyl donor balance and downstream effects on gene expression
Experimental protocols commonly employ in vitro enzyme assays, adipocyte cell culture systems, and metabolic profiling models to characterize the biochemical effects of 5-Amino-1MQ.
Weight and Adipose Tissue Research
Due to its role in metabolic enzyme modulation, 5-Amino-1MQ has been studied in research models related to adipose tissue and energy balance. Key areas of investigation include:
- Adipogenesis Regulation: Evaluation of fat cell formation and differentiation processes
- Lipid Storage and Mobilization: Studies examining triglyceride accumulation and lipid utilization pathways
- Energy Expenditure Models: Investigation of metabolic rate, substrate utilization, and energy output
- Insulin Sensitivity Research: Analysis of glucose handling and insulin signaling pathways in metabolic systems
- Obesity-Related Pathway Studies: Examination of molecular pathways associated with metabolic imbalance
This body of research utilizes adipocyte cultures and metabolic assessment models to evaluate cellular and biochemical responses to NNMT modulation.
Mitochondrial and Bioenergetics Research
5-Amino-1MQ has been explored in studies focused on mitochondrial function and cellular bioenergetics, including:
- Mitochondrial Efficiency: Evaluation of oxidative phosphorylation and electron transport chain activity
- ATP Production Studies: Investigation of cellular energy generation under metabolic stress conditions
- Metabolic Flexibility Models: Research on substrate switching between carbohydrates and lipids
- Cellular Stress Adaptation: Examination of mitochondrial responses to metabolic and oxidative stress
Laboratory protocols assess mitochondrial respiration, energy output, and adaptive responses using biochemical assays and metabolic flux analysis.
Inflammatory and Cellular Signaling Research
Additional research applications explore the influence of 5-Amino-1MQ on cellular signaling pathways associated with metabolic stress and inflammation, including:
- Cytokine Signaling Studies: Investigation of inflammatory mediator expression in metabolic tissue models
- Cellular Stress Response Pathways: Analysis of stress-activated signaling cascades under metabolic challenge
- Metabolic Inflammation Models: Research into low-grade inflammatory processes associated with metabolic dysregulation
- Cellular Homeostasis Mechanisms: Examination of regulatory pathways maintaining metabolic balance
Research in this domain focuses on understanding how NNMT inhibition via 5-Amino-1MQ influences metabolic signaling, inflammatory responses, and cellular equilibrium under experimental conditions.
Laboratory Handling and Storage Protocols
Lyophilized Powder Storage
- Store at –20°C to –80°C in the original, sealed vial
- Protect from light exposure and moisture
- A desiccated storage environment is recommended
- Stability data suggests extended stability when stored at −20 °C or below.
Reconstituted Solution Storage
- Short-term storage: Up to 7 days at 4°C
- Long-term storage: Store at –20°C in aliquots
- Use single-use aliquots to preserve peptide integrity
- Minimize freeze–thaw cycles; single-use aliquots are strongly recommended
Stability Characteristics
5-Amino-1MQ is a small-molecule research compound with a stable chemical profile under standard laboratory handling conditions. When stored properly and prepared using appropriate solvents, it demonstrates good solubility and resistance to rapid degradation. These properties support reliable use across analytical, biochemical, and cellular research applications when standard laboratory protocols are followed.
Frequently Asked Questions
What is 5-Amino-1MQ?
5-Amino-1MQ is a small-molecule research compound studied for its role as a NNMT (nicotinamide N-methyltransferase) pathway inhibitor in laboratory and preclinical research settings. It is intended strictly for research use only and is not approved for human or veterinary use.
What is 5-Amino-1MQ commonly researched for?
In research environments, 5-Amino-1MQ is studied for its involvement in:
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Cellular metabolism pathways
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NNMT-related signaling mechanisms
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Energy balance and metabolic regulation models
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Epigenetic and methylation research
These studies are experimental and primarily conducted in in-vitro and animal models.
Is 5-Amino-1MQ a peptide?
Despite being commonly grouped with peptides, 5-Amino-1MQ is a small-molecule compound, not a peptide chain. It is often categorized alongside research peptides due to its similar research applications and handling protocols.
How is 5-Amino-1MQ supplied?
5-Amino-1MQ is typically supplied as a lyophilized (freeze-dried) powder or crystalline solid in sealed research vials. This format supports stability during storage and transport prior to laboratory preparation.
How should unreconstituted 5-Amino-1MQ be stored?
Unreconstituted 5-Amino-1MQ should be stored:
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Long-term: −20 °C or below
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Short-term: 2–8 °C (refrigerated)
Vials should remain sealed and protected from light, heat, and moisture.
Does 5-Amino-1MQ require a Certificate of Analysis (COA)?
Yes. A Certificate of Analysis (COA) should be available for each batch, verifying identity, purity, and analytical testing results. COAs help ensure transparency and consistency for research use.
Is 5-Amino-1MQ FDA-approved?
No. 5-Amino-1MQ is not FDA-approved as a drug, supplement, or therapeutic product. It is sold strictly as a research compound and must not be marketed for human consumption or medical use.
Can 5-Amino-1MQ be used alongside other compounds in research?
In controlled research settings, 5-Amino-1MQ may be studied independently or alongside other compounds to evaluate pathway interactions or comparative effects. All use should follow proper laboratory protocols and ethical research standards.
Research Background
For a referenced overview of what the published research on this compound examines — and what it does not establish — see What Is 5-Amino-1MQ? Research Background and Study Areas. It cites peer-reviewed sources and contains no dosing guidance.
This product is not for human consumption. It is sold strictly for research and educational purposes and is not intended to diagnose, treat, cure, or prevent any disease.
Any clinical data or research information referenced on this page is derived from peer-reviewed scientific literature and official publications. This information is provided for educational reference only and does not constitute medical advice or product claims.
By purchasing this product, you acknowledge that you are a qualified researcher and agree to use it in full compliance with all applicable laws and regulations.
