For laboratory research use only. Not for human or veterinary use. This is educational reference information, not medical advice.
Research Database / Peptides / 5-Amino-1MQ
5-Amino-1MQ · 5-Amino-1-methylquinolinium

5-Amino-1MQ

Cellular Research Compounds
Overview Research Publications Laboratory FAQ References
Overview
Scientific name5-Amino-1-methylquinolinium
Synonyms1-Methylquinolin-5-amine
Abbreviation5-Amino-1MQ
CAS Number685079-15-6
Molecular formulaC10H11N2+
Molecular weight159.21 g/mol (average)
PubChem CID950107
2D / 3D structure
2D chemical structure of 5-Amino-1MQ
Research Summary

Mechanisms under investigation

The following are areas of ongoing preclinical investigation. They describe hypotheses and observations reported in the literature, not established clinical effects.

Evidence tiers below reflect how much has been studied in each model type. Counts describe research volume — they do not indicate proven efficacy, safety, or clinical consensus.

Evidence base (transparent counts)

Cellular studies 3 publications
Animal studies 2 publications
Human observational reports 0 publications
Controlled human trials 0 publications
Review articles 0 publications
Publication Library

Selected literature

Filter by study model. Each record is classified for the evidence base above.

2025
Cell-based study evaluating NNMT inhibitors, including 5-amino-1-methylquinolinium, for effects on viability, reactive oxygen species production and apoptosis in osteosarcoma and Merkel cell carcinoma lines.Cellular · PubMed (41301471)
2022
Preclinical study examining NNMT inhibition combined with a reduced calorie diet and the resulting microbiome composition in diet-induced obese mice.Animal · mouse · PubMed (35013352)
2021
In vitro study reporting effects of a small molecule NNMT inhibitor on proliferation of HeLa cervical cancer cells.Cellular · PubMed (33645410)
2021
Bioanalytical method development study validating an LC-MS/MS assay for 5-amino-1-methylquinolinium in rat plasma and applying it to pharmacokinetic and oral bioavailability measurements.Animal · rat · PubMed (34304009)
2017
Medicinal-chemistry study examining structure-activity relationships of small molecule nicotinamide N-methyltransferase inhibitors including quinolinium analogs related to 5-amino-1MQ.Cellular · PubMed (28548833)

Each record maps to a structured evidence row with study model, species, and support level.

Laboratory Information

Handling and reference

Molecular weight calculator

Average-mass estimate from a one-letter sequence.

Reconstitution calculator

Laboratory concentration only. Not dosing guidance.

Frequently Asked Questions
What is 5-Amino-1MQ?
5-Amino-1MQ is a research compound; the identity and structure data shown here are compiled from public chemical databases (primarily PubChem). For laboratory research use only.
What research models has it been studied in?
The literature indexed here is predominantly cellular (in vitro) and animal studies. See the evidence base and publication library above for the transparent counts by study model.
Is there controlled human clinical trial evidence?
Controlled human clinical trials are counted separately in the evidence base above. Cellular and animal findings do not establish human clinical effects.
How is it stored and handled in a laboratory?
Refer to the laboratory information section above.
Is this intended for human use?
No. All information and materials are for laboratory research use only — not for human or veterinary use, and not intended to diagnose, treat, cure, or prevent any disease.
Documentation

Research material & documentation

This profile is an educational reference. Lot-level laboratory documentation for materials supplied by Peptide Titans is published openly.

5-Amino-1MQ research material →  ·  Lot-specific Certificates of Analysis →  ·  How lots are tested →

References and Citation

Evidence records

  1. Cell-based study evaluating NNMT inhibitors, including 5-amino-1-methylquinolinium, for effects on viability, reactive oxygen species production and apoptosis in osteosarcoma and Merkel cell carcinoma lines. (2025) — in vitro — PubMed.
  2. Preclinical study examining NNMT inhibition combined with a reduced calorie diet and the resulting microbiome composition in diet-induced obese mice. (2022) — in vivo — PubMed.
  3. In vitro study reporting effects of a small molecule NNMT inhibitor on proliferation of HeLa cervical cancer cells. (2021) — in vitro — PubMed.
  4. Bioanalytical method development study validating an LC-MS/MS assay for 5-amino-1-methylquinolinium in rat plasma and applying it to pharmacokinetic and oral bioavailability measurements. (2021) — in vivo — PubMed.
  5. Medicinal-chemistry study examining structure-activity relationships of small molecule nicotinamide N-methyltransferase inhibitors including quinolinium analogs related to 5-amino-1MQ. (2017) — in vitro — PubMed.

Every record carries a study model, species, support level and review status in the evidence table.

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For laboratory research use only. Not for human or veterinary use. Educational reference information — not medical advice.