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Tesamorelin

Name: Tesamorelin
Brand: Peptide Titans
SKU: 569
Availability: InStock

Price range: $289.99 through $529.99

Tesamorelin is a synthetic analog of growth hormone–releasing hormone (GHRH) studied for its role in stimulating endogenous growth hormone secretion via activation of GHRH receptors in the pituitary. In research settings, it’s explored for its effects on IGF-1 signaling, lipid metabolism pathways, and metabolic regulation mechanisms. Intended for research use only, not for human or veterinary use.

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Molecular Characteristics

Complete Specifications

CAS Registry Number: 218949-48-5
PubChem CID: Not available
Peptide Classification: Synthetic 44-amino-acid growth hormone–releasing hormone (GHRH) analog
Molecular Formula: C₂₂₁H₃₆₆N₇₂O₆₇
Molecular Weight: ~5,135.9 Da

Structural Composition

Amino Acid Sequence:
44-amino-acid synthetic analog of human growth hormone–releasing hormone (GHRH) with targeted amino acid substitutions for enhanced stability
Length: 44 amino acids (modified)

Physical Properties

Appearance: White to off-white lyophilized powder
Solubility: Water, bacteriostatic water, buffered aqueous solutions (e.g., PBS)

Structural & Stability Notes

Tesamorelin is a synthetic 44-amino-acid analog of growth hormone–releasing hormone (GHRH) engineered with targeted amino acid substitutions to enhance resistance to enzymatic degradation under research conditions. Its extended peptide chain and structural modifications provide improved stability compared to shorter GHRH fragments. As with other long-chain peptides, lyophilized storage under cold, dry conditions is recommended. Protection from moisture, light exposure, and repeated freeze–thaw cycles helps preserve structural integrity and maintain analytical consistency during laboratory applications.

Research Applications

Growth Hormone–Releasing Hormone (GHRH) Signaling Research

Tesamorelin is utilized as a synthetic growth hormone–releasing hormone (GHRH) analog in research studies examining pituitary signaling and growth hormone regulatory pathways. Laboratory investigations focus on its role in:

GHRH Receptor Activation Models: Investigation of receptor binding affinity and intracellular signaling cascades
cAMP and PKA Pathway Studies: Evaluation of second messenger activation following receptor stimulation
Pituitary Somatotroph Research: Analysis of intracellular mechanisms regulating growth hormone release dynamics
Receptor Desensitization Models: Examination of adaptive responsiveness following repeated stimulation
Peptide Stability Studies: Investigation of structural persistence and signaling duration in laboratory systems

Experimental protocols commonly employ receptor-binding assays, pituitary cell cultures, and intracellular signaling analyses to characterize Tesamorelin-mediated endocrine responses.

IGF-1 Axis and Endocrine Regulation Research

Tesamorelin has been examined in research contexts involving growth hormone–associated endocrine networks and insulin-like growth factor (IGF-1) signaling pathways. Key areas of investigation include:

IGF-1 Expression Models: Evaluation of hepatic-associated transcriptional regulation following growth hormone signaling
AKT and mTOR Pathway Studies: Investigation of intracellular cascades associated with anabolic signaling models
Endocrine Feedback Regulation Research: Analysis of hypothalamic–pituitary–liver axis coordination
Somatostatin Interaction Models: Research into counter-regulatory signaling within growth hormone systems
Hormonal Pulse Pattern Studies: Examination of temporal signaling dynamics under controlled laboratory conditions

These studies utilize hormone quantification assays, transcription factor profiling, and intracellular kinase activation analyses to evaluate endocrine signaling outcomes.

Metabolic and Lipid Signaling Research

Tesamorelin has also been explored in research models examining metabolic regulation and lipid-associated intracellular mechanisms, including:

Adipocyte Signaling Studies: Evaluation of intracellular cascades influencing lipid mobilization models
AMPK Pathway Research: Investigation of energy-sensing signaling mechanisms
Glucose Homeostasis Models: Analysis of intracellular pathways associated with metabolic balance
Hepatic Signaling Research: Examination of growth hormone–mediated liver regulatory pathways

Laboratory protocols assess metabolic enzyme activity, gene expression markers, and intracellular signaling dynamics using biochemical and molecular techniques.

Cellular Signaling and Endocrine Network Research

Additional research applications explore Tesamorelin’s influence on intracellular regulatory systems involved in growth hormone axis coordination, including:

MAPK and ERK Pathway Studies: Investigation of downstream cascades associated with receptor-mediated signaling
Gene Expression Profiling: Analysis of transcriptional responses linked to endocrine regulation
Receptor Sensitivity Research: Examination of adaptive signaling modulation within GHRH receptor systems
Integrated Hormonal Feedback Models: Analysis of coordinated endocrine networks maintaining systemic equilibrium

Research in this domain focuses on understanding how Tesamorelin influences GHRH receptor–mediated signaling pathways, growth hormone regulatory systems, and metabolic-associated intracellular responses under controlled experimental conditions.

Laboratory Handling and Storage Protocols

Lyophilized Powder Storage

Store at –20°C to –80°C in the original, sealed vial
Protect from light exposure and moisture
A desiccated storage environment is recommended
Stability data suggests extended stability when stored at −20 °C or below.

Reconstitution Guidelines

Reconstitute using sterile water, bacteriostatic water (0.9% benzyl alcohol), or an appropriate laboratory buffer
Introduce solvent slowly along the vial wall to minimize foaming
Mix using gentle swirling; avoid vigorous agitation or shaking
Allow complete dissolution prior to use (typically 1–2 minutes)
Ensure the final solution is within a physiologically neutral pH range appropriate for laboratory use

Reconstituted Solution Storage

Short-term storage: Up to 7 days at 4°C
Long-term storage: Store at –20°C in aliquots
Use single-use aliquots to preserve peptide integrity
Minimize freeze–thaw cycles; single-use aliquots are strongly recommended

Stability Characteristics

Tesamorelin is a synthetic peptide research compound that demonstrates stable handling characteristics when managed according to standard peptide laboratory protocols. Proper cold storage of the lyophilized material, protection from light, careful reconstitution, and minimized freeze–thaw exposure help preserve structural integrity and solubility. When handled appropriately, Tesamorelin supports consistent use in in vitro and analytical research applications.

Frequently Asked Questions

What is Tesamorelin?

Tesamorelin is a synthetic peptide analog of GHRH designed to activate the GHRH receptor in experimental models. It is used in research investigating endocrine signaling and growth hormone regulatory mechanisms.

What is Tesamorelin commonly researched for?

In laboratory and preclinical models, Tesamorelin is studied for:

GHRH receptor activation
Growth hormone release signaling
IGF-1 pathway investigation
Endocrine and metabolic signaling research
Hypothalamic–pituitary axis pathway models

All applications are exploratory and conducted in controlled research environments.

How does Tesamorelin differ from CJC-1295?

Both are GHRH analogs studied in endocrine research, but they differ structurally and in stability characteristics. CJC-1295 may be available in DAC and non-DAC forms, which can influence activity duration in experimental models, whereas Tesamorelin has its own distinct sequence and pharmacological profile.

Is Tesamorelin the same as growth hormone (GH)?

No. Tesamorelin stimulates the GHRH receptor, which in turn influences endogenous growth hormone signaling pathways. It is not growth hormone itself.

How is Tesamorelin supplied?

Tesamorelin is typically supplied as a lyophilized (freeze-dried) powder in sealed research vials to preserve stability during storage and shipment.

How should unreconstituted Tesamorelin be stored?

Lyophilized Tesamorelin should be stored:

Long-term: −20 °C to −80 °C
Short-term: 2–8 °C

Keep vials sealed and protected from light and moisture until use.

How should reconstituted Tesamorelin be handled and stored?

Once reconstituted:

Store at 2–8 °C for short-term laboratory use
For extended storage, aliquot and freeze at −20 °C or below
Minimize freeze–thaw cycles using single-use aliquots
Gently swirl to mix; avoid vigorous agitation

Does Tesamorelin require a Certificate of Analysis (COA)?

Yes. A Certificate of Analysis (COA) should be available for each batch, verifying peptide identity, purity, and analytical testing results to ensure research quality and traceability.

Is Tesamorelin FDA-approved?

Research-grade Tesamorelin is not FDA-approved as a drug, supplement, or therapeutic product. It is sold exclusively as a research compound and must not be marketed or used for diagnostic, therapeutic, or consumption purposes.

⚠️ Research Use Only

This product is not for human consumption. It is sold strictly for research and educational purposes and is not intended to diagnose, treat, cure, or prevent any disease.

Any clinical data or research information referenced on this page is derived from peer-reviewed scientific literature and official publications. This information is provided for educational reference only and does not constitute medical advice or product claims.

By purchasing this product, you acknowledge that you are a qualified researcher and agree to use it in full compliance with all applicable laws and regulations.