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KPV

Name: KPV
Brand: Peptide Titans
SKU: 543
Availability: InStock

Price range: $149.99 through $189.99

KPV (Lysine–Proline–Valine) is a synthetic tripeptide fragment derived from alpha-melanocyte–stimulating hormone (α-MSH), studied for its role in inflammatory signaling modulation and immune-related pathways. In research settings, it’s explored for potential effects on cytokine activity, epithelial barrier integrity, and cellular repair mechanisms. Intended for research use only, not for human or veterinary use.

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Description
Additional information

Molecular Characteristics

Complete Specifications

CAS Registry Number: Not assigned (synthetic tripeptide)
PubChem CID: Not available
Peptide Classification: Synthetic tripeptide (α-MSH fragment)
Molecular Formula: C₁₆H₃₀N₄O₄
Molecular Weight: ~342.44 Da

Structural Composition

Amino Acid Sequence:
Lys-Pro-Val (KPV)
Length: 3 amino acids

Physical Properties

Appearance: White to off-white lyophilized powder
Solubility: Water, bacteriostatic water, buffered aqueous solutions (e.g., PBS)

Structural & Stability Notes

KPV is a short synthetic tripeptide corresponding to a fragment of alpha-melanocyte-stimulating hormone (α-MSH). Its minimal three-amino-acid structure supports strong aqueous solubility and straightforward laboratory handling. Due to its small size, the peptide exhibits predictable stability characteristics when stored in lyophilized form. Protection from moisture, light exposure, and repeated freeze–thaw cycles helps maintain structural integrity and analytical consistency during research applications.

Research Applications

Inflammatory Signaling and Cytokine Modulation Research

KPV is utilized as a research peptide fragment in studies examining inflammatory signaling pathways and cytokine regulation mechanisms. Laboratory investigations focus on its role in:

NF-κB Pathway Models: Investigation of transcription factor signaling associated with inflammatory mediator expression
Cytokine Expression Studies: Evaluation of TNF-α, IL-1β, and related signaling pathways under experimental conditions
Immune Cell Signaling Research: Analysis of macrophage and epithelial cell response dynamics
Inflammation Resolution Mechanisms: Examination of regulatory pathways involved in immune response balance
Signal Transduction Modulation: Investigation of intracellular cascades influencing inflammatory gene transcription

Experimental protocols commonly employ cytokine quantification assays, macrophage and epithelial cell culture systems, and transcriptional profiling techniques to characterize KPV-mediated signaling responses.

Epithelial Barrier and Gastrointestinal Research

KPV has been examined in research contexts involving epithelial barrier integrity and gastrointestinal signaling models. Key areas of investigation include:

Intestinal Barrier Integrity Models: Evaluation of tight junction stability and permeability control mechanisms
Epithelial Cell Signaling Studies: Investigation of cellular stress response pathways within gut tissue models
Mucosal Environment Research: Analysis of inflammatory mediator balance in epithelial systems
Microbiome Interaction Models: Research into peptide signaling effects within experimental gut ecosystems
Oxidative Stress Modulation: Examination of redox balance in epithelial tissues

These studies utilize permeability assays, epithelial cell cultures, and inflammatory biomarker profiling to evaluate barrier-related signaling dynamics.

Dermal and Skin Biology Research

KPV has also been explored in research models examining dermal inflammatory pathways and epithelial tissue regulation, including:

Keratinocyte Signaling Studies: Evaluation of epidermal cell response under inflammatory stress conditions
Dermal Cytokine Regulation Models: Investigation of immune mediator expression in skin tissue systems
Barrier Repair Signaling Research: Analysis of epithelial recovery pathways in controlled models
Extracellular Matrix Interaction Studies: Examination of dermal structural regulation mechanisms

Laboratory protocols assess cytokine signaling, epithelial cohesion, and inflammatory pathway modulation using biochemical and imaging-based techniques.

Cellular Signaling and Immune Homeostasis Research

Additional research applications explore KPV’s influence on intracellular regulatory systems involved in immune balance and tissue homeostasis, including:

MAPK and JAK-STAT Pathway Studies: Investigation of inflammatory signal transduction cascades
Gene Expression Profiling: Analysis of transcriptional responses associated with immune modulation
Apoptosis and Cell Survival Models: Research into cellular adaptation during inflammatory stress
Integrated Immune Feedback Systems: Examination of coordinated signaling networks maintaining tissue equilibrium

Research in this domain focuses on understanding how KPV influences inflammatory signaling pathways, epithelial barrier regulation, and immune homeostasis under controlled experimental conditions.

Laboratory Handling and Storage Protocols

Lyophilized Powder Storage

Store at –20°C to –80°C in the original, sealed vial
Protect from light exposure and moisture
A desiccated storage environment is recommended
Stability data suggests extended stability when stored at −20 °C or below.

Reconstitution Guidelines

Reconstitute using sterile water, bacteriostatic water (0.9% benzyl alcohol), or an appropriate laboratory buffer
Introduce solvent slowly along the vial wall to minimize foaming
Mix using gentle swirling; avoid vigorous agitation or shaking
Allow complete dissolution prior to use (typically 1–2 minutes)
Ensure the final solution is within a physiologically neutral pH range appropriate for laboratory use

Reconstituted Solution Storage

Short-term storage: Up to 7 days at 4°C
Long-term storage: Store at –20°C in aliquots
Use single-use aliquots to preserve peptide integrity
Minimize freeze–thaw cycles; single-use aliquots are strongly recommended

Stability Characteristics

KPV is a synthetic tripeptide research compound that demonstrates stable handling characteristics when managed according to standard peptide laboratory protocols. Proper cold storage of the lyophilized material, careful reconstitution, and minimized freeze–thaw exposure help maintain structural integrity and solubility. When handled appropriately, KPV supports consistent use in in vitro and analytical research applications.

Frequently Asked Questions

What is KPV?

KPV is a short-chain tripeptide consisting of the amino acids lysine, proline, and valine. It represents a biologically active fragment of α-MSH and is used in research investigating inflammatory pathway signaling.

What is KPV commonly researched for?

In laboratory and preclinical models, KPV is studied for:

Cytokine signaling modulation
Inflammatory pathway investigation
NF-κB pathway research
Epithelial and barrier function studies
Multi-peptide synergy research

All applications are exploratory and conducted in controlled research environments.

Is KPV the same as α-MSH?

No. KPV is a fragment of α-MSH, not the full peptide. It contains a specific three–amino acid sequence believed to retain certain signaling properties in experimental models.

Is KPV a naturally occurring peptide?

The KPV sequence is derived from a naturally occurring hormone (α-MSH). Synthetic KPV used in research is manufactured to replicate this specific tripeptide fragment.

How is KPV supplied?

KPV is typically supplied as a lyophilized (freeze-dried) powder in sealed research vials to maintain stability during storage and shipment.

How should unreconstituted KPV be stored?

Lyophilized KPV should be stored:

Long-term: −20 °C to −80 °C
Short-term: 2–8 °C

Keep vials sealed and protected from light and moisture until use.

How should reconstituted KPV be handled and stored?

Once reconstituted:

Store at 2–8 °C for short-term laboratory use
For extended storage, aliquot and freeze at −20 °C or below
Minimize freeze–thaw cycles using single-use aliquots
Gently swirl to mix; avoid vigorous agitation

Does KPV require a Certificate of Analysis (COA)?

Yes. A Certificate of Analysis (COA) should be available for each batch, verifying the identity and purity of each peptide component within the blend to ensure research quality and traceability.

Is KPV FDA-approved?

No. KPV is not FDA-approved as a drug, supplement, or therapeutic product. It is sold exclusively as a research compound and must not be marketed or used for diagnostic, therapeutic, or consumption purposes.

⚠️ Research Use Only

This product is not for human consumption. It is sold strictly for research and educational purposes and is not intended to diagnose, treat, cure, or prevent any disease.

Any clinical data or research information referenced on this page is derived from peer-reviewed scientific literature and official publications. This information is provided for educational reference only and does not constitute medical advice or product claims.

By purchasing this product, you acknowledge that you are a qualified researcher and agree to use it in full compliance with all applicable laws and regulations.