Molecular Characteristics
Complete Specifications
Structural Composition
Physical Properties
Sermorelin is a synthetic 29-amino-acid peptide corresponding to the biologically active N-terminal fragment of growth hormone–releasing hormone (GHRH 1–29). Its mid-length structure provides moderate conformational stability while remaining susceptible to enzymatic degradation in biological systems. Lyophilized storage under cold, dry conditions is recommended to maintain stability. Protection from moisture, light exposure, and repeated freeze–thaw cycles helps preserve structural integrity and maintain analytical consistency during laboratory research applications.
Analysis & Documentation
Identity
Each production lot is checked against the reference structure recorded for this compound:
- Classification — Synthetic 29-amino-acid growth hormone–releasing hormone (GHRH) fragment
- Molecular formula — C₁₄₉H₂₄₆N₄₄O₄₂
- Expected mass — ~3,357.9 Da
- CAS registry — 86168-78-7
- Chain length — 29 amino acids
- PubChem CID — Not available
Analytical Methods
Testing is carried out per lot by an independent laboratory. The methods measure what the material is and how much of it is the target compound:
- RP-HPLC — reverse-phase separation of the target from process-related impurities; purity is reported as area percent of the main peak
- Mass spectrometry — observed mass compared against the expected molecular mass above
- Retention time — compared against a reference standard run under the same conditions
- Chromatogram — reproduced on the certificate so the peak and any shoulders can be inspected directly
Material & Documentation
What arrives, and how to tie it back to its paperwork:
- Appearance as supplied — White to off-white lyophilized powder
- Solubility — Water, buffered aqueous solutions (e.g., PBS)
- Lot number — printed on the container label and used to look up the certificate
- Certificate — indexed by lot at Certificates of Analysis
Laboratory Handling and Storage Protocols
Lyophilized Powder Storage
- Store at –20°C to –80°C in the original, sealed vial
- Protect from light exposure and moisture
- A desiccated storage environment is recommended
- Stability data suggests extended stability when stored at −20 °C or below.
Reconstituted Solution Storage
- Short-term storage: Up to 7 days at 4°C
- Long-term storage: Store at –20°C in aliquots
- Use single-use aliquots to preserve peptide integrity
- Minimize freeze–thaw cycles; single-use aliquots are strongly recommended
Stability Characteristics
Sermorelin is a synthetic peptide research compound that demonstrates stable handling characteristics when managed according to standard peptide laboratory protocols. Proper cold storage of the lyophilized material, protection from light, careful reconstitution, and minimized freeze–thaw exposure help preserve structural integrity and solubility. When handled appropriately, Sermorelin supports consistent use in in vitro and analytical research applications.
Frequently Asked Questions
What is Sermorelin?
Sermorelin is a synthetic peptide analog of the active portion of GHRH. It is used in research to investigate growth hormone regulatory pathways and endocrine signaling mechanisms.
How does Sermorelin differ from Tesamorelin?
Both are GHRH analogs studied in endocrine research. Sermorelin represents the 1–29 active fragment of GHRH, while Tesamorelin is a modified analog with structural changes that may influence stability and signaling characteristics in experimental models.
Is Sermorelin the same as growth hormone (GH)?
No. Sermorelin is a GHRH analog studied at the GHRH receptor. It is not growth hormone itself.
Is Sermorelin a peptide?
Yes. Sermorelin is a synthetic peptide composed of 29 amino acids.
How is Sermorelin supplied?
Sermorelin is typically supplied as a lyophilized (freeze-dried) powder in sealed research vials to preserve stability during storage and shipment.
How should unreconstituted Sermorelin be stored?
Lyophilized Sermorelin should be stored:
- Long-term: −20 °C to −80 °C
- Short-term: 2–8 °C
Keep vials sealed and protected from light and moisture until use.
How should reconstituted Sermorelin be handled and stored?
Once reconstituted:
- Store at 2–8 °C for short-term laboratory use
- For extended storage, aliquot and freeze at −20 °C or below
- Minimize freeze–thaw cycles using single-use aliquots
- Gently swirl to mix; avoid vigorous agitation
Does Sermorelin require a Certificate of Analysis (COA)?
Yes. A Certificate of Analysis (COA) should be available for each batch of Sermorelin, verifying identity, purity, and analytical testing results to ensure research quality and traceability.
Is Sermorelin FDA-approved?
When sold as a research compound, Sermorelin is not FDA-approved for diagnostic, therapeutic, or consumption purposes and must be marketed strictly for laboratory research use.
Research Background
For a referenced overview of the published research and this compound’s unusual regulatory history, see What Is Sermorelin? Research Background and Study Areas. It cites peer-reviewed sources and contains no dosing guidance.
This product is not for human consumption. It is sold strictly for research and educational purposes and is not intended to diagnose, treat, cure, or prevent any disease.
Any clinical data or research information referenced on this page is derived from peer-reviewed scientific literature and official publications. This information is provided for educational reference only and does not constitute medical advice or product claims.
By purchasing this product, you acknowledge that you are a qualified researcher and agree to use it in full compliance with all applicable laws and regulations.
