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5-Amino-1MQ

Name: 5-Amino-1MQ
Brand: Peptide Titans
SKU: 479
Availability: InStock

Price range: $149.99 through $419.99

5-Amino-1MQ is a small-molecule research compound studied for its role as a NNMT (nicotinamide N-methyltransferase) inhibitor. In laboratory settings, it’s commonly researched for its potential effects on cellular metabolism, energy regulation, and adipose (fat) tissue pathways. It is intended for research use only and not for human or veterinary use.

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Description
Additional information

Molecular Characteristics

Complete Specifications

CAS Registry Number: 14047-29-1
PubChem CID: 122098
Peptide Classification: Synthetic small-molecule quinolinium compound
Molecular Formula: C₁₀H₁₁IN₂
Molecular Weight: 286.11 Da

Structural Composition

Chemical Structure:
5-Amino-1-methylquinolinium iodide, consisting of a quaternary quinoline ring substituted with an amino group and paired with an iodide counterion
Length: Not applicable (non-peptide compound)

Physical Properties

Appearance: Yellow to off-white crystalline or lyophilized powder
Solubility: Water, DMSO, methanol; soluble in polar organic solvents

Structural & Stability Notes

5-Amino-1MQ is a low-molecular-weight quaternary ammonium compound featuring a positively charged quinolinium core. The permanent cationic charge enhances aqueous solubility and contributes to chemical stability under controlled laboratory conditions. The iodide counterion stabilizes the salt form, while the aromatic ring system provides structural rigidity. Due to its non-peptide nature, the compound is not subject to enzymatic peptide degradation and demonstrates favorable shelf stability when stored in a dry, light-protected environment.

Research Applications

Metabolic and Cellular Regulation Research

5-Amino-1MQ is primarily utilized as a research compound in studies examining cellular metabolism and enzymatic regulation. Laboratory investigations focus on its role in:

NNMT Inhibition Models: Investigation of nicotinamide N-methyltransferase (NNMT) activity and its influence on cellular metabolic pathways
NAD+ Metabolism Research: Analysis of nicotinamide utilization, methylation balance, and cellular energy regulation
Cellular Energy Homeostasis: Examination of mitochondrial efficiency, ATP production, and metabolic flux under experimental conditions
Adipocyte Function Studies: Research into adipose cell differentiation, lipid metabolism, and energy storage mechanisms
Epigenetic and Methylation Pathways: Investigation of methyl donor balance and downstream effects on gene expression

Experimental protocols commonly employ in vitro enzyme assays, adipocyte cell culture systems, and metabolic profiling models to characterize the biochemical effects of 5-Amino-1MQ.

Weight and Adipose Tissue Research

Due to its role in metabolic enzyme modulation, 5-Amino-1MQ has been studied in research models related to adipose tissue and energy balance. Key areas of investigation include:

Adipogenesis Regulation: Evaluation of fat cell formation and differentiation processes
Lipid Storage and Mobilization: Studies examining triglyceride accumulation and lipid utilization pathways
Energy Expenditure Models: Investigation of metabolic rate, substrate utilization, and energy output
Insulin Sensitivity Research: Analysis of glucose handling and insulin signaling pathways in metabolic systems
Obesity-Related Pathway Studies: Examination of molecular pathways associated with metabolic imbalance

This body of research utilizes adipocyte cultures and metabolic assessment models to evaluate cellular and biochemical responses to NNMT modulation.

Mitochondrial and Bioenergetics Research

5-Amino-1MQ has been explored in studies focused on mitochondrial function and cellular bioenergetics, including:

Mitochondrial Efficiency: Evaluation of oxidative phosphorylation and electron transport chain activity
ATP Production Studies: Investigation of cellular energy generation under metabolic stress conditions
Metabolic Flexibility Models: Research on substrate switching between carbohydrates and lipids
Cellular Stress Adaptation: Examination of mitochondrial responses to metabolic and oxidative stress

Laboratory protocols assess mitochondrial respiration, energy output, and adaptive responses using biochemical assays and metabolic flux analysis.

Inflammatory and Cellular Signaling Research

Additional research applications explore the influence of 5-Amino-1MQ on cellular signaling pathways associated with metabolic stress and inflammation, including:

Cytokine Signaling Studies: Investigation of inflammatory mediator expression in metabolic tissue models
Cellular Stress Response Pathways: Analysis of stress-activated signaling cascades under metabolic challenge
Metabolic Inflammation Models: Research into low-grade inflammatory processes associated with metabolic dysregulation
Cellular Homeostasis Mechanisms: Examination of regulatory pathways maintaining metabolic balance

Research in this domain focuses on understanding how NNMT inhibition via 5-Amino-1MQ influences metabolic signaling, inflammatory responses, and cellular equilibrium under experimental conditions.

Laboratory Handling and Storage Protocols

Lyophilized Powder Storage

Store at –20°C to –80°C in the original, sealed vial
Protect from light exposure and moisture
A desiccated storage environment is recommended
Stability data suggests extended stability when stored at −20 °C or below.

Reconstitution Guidelines

Reconstitute using sterile water, bacteriostatic water (0.9% benzyl alcohol), or an appropriate laboratory buffer
Introduce solvent slowly along the vial wall to minimize foaming
Mix using gentle swirling; avoid vigorous agitation or shaking
Allow complete dissolution prior to use (typically 1–2 minutes)
Ensure the final solution is within a physiologically neutral pH range appropriate for laboratory use

Reconstituted Solution Storage

Short-term storage: Up to 7 days at 4°C
Long-term storage: Store at –20°C in aliquots
Use single-use aliquots to preserve peptide integrity
Minimize freeze–thaw cycles; single-use aliquots are strongly recommended

Stability Characteristics

5-Amino-1MQ is a small-molecule research compound with a stable chemical profile under standard laboratory handling conditions. When stored properly and prepared using appropriate solvents, it demonstrates good solubility and resistance to rapid degradation. These properties support reliable use across analytical, biochemical, and cellular research applications when standard laboratory protocols are followed.

Frequently Asked Questions

What is 5-Amino-1MQ?

5-Amino-1MQ is a small-molecule research compound studied for its role as a NNMT (nicotinamide N-methyltransferase) pathway inhibitor in laboratory and preclinical research settings. It is intended strictly for research use only and is not approved for human or veterinary use.

What is 5-Amino-1MQ commonly researched for?

In research environments, 5-Amino-1MQ is studied for its involvement in:

Cellular metabolism pathways
NNMT-related signaling mechanisms
Energy balance and metabolic regulation models
Epigenetic and methylation research

These studies are experimental and primarily conducted in in-vitro and animal models.

Is 5-Amino-1MQ a peptide?

Despite being commonly grouped with peptides, 5-Amino-1MQ is a small-molecule compound, not a peptide chain. It is often categorized alongside research peptides due to its similar research applications and handling protocols.

How is 5-Amino-1MQ supplied?

5-Amino-1MQ is typically supplied as a lyophilized (freeze-dried) powder or crystalline solid in sealed research vials. This format supports stability during storage and transport prior to laboratory preparation.

How should unreconstituted 5-Amino-1MQ be stored?

Unreconstituted 5-Amino-1MQ should be stored:

Long-term: −20 °C or below
Short-term: 2–8 °C (refrigerated)

Vials should remain sealed and protected from light, heat, and moisture.

Does 5-Amino-1MQ require a Certificate of Analysis (COA)?

Yes. A Certificate of Analysis (COA) should be available for each batch, verifying identity, purity, and analytical testing results. COAs help ensure transparency and consistency for research use.

Is 5-Amino-1MQ FDA-approved?

No. 5-Amino-1MQ is not FDA-approved as a drug, supplement, or therapeutic product. It is sold strictly as a research compound and must not be marketed for human consumption or medical use.

Can 5-Amino-1MQ be used alongside other compounds in research?

In controlled research settings, 5-Amino-1MQ may be studied independently or alongside other compounds to evaluate pathway interactions or comparative effects. All use should follow proper laboratory protocols and ethical research standards.

⚠️ Research Use Only

This product is not for human consumption. It is sold strictly for research and educational purposes and is not intended to diagnose, treat, cure, or prevent any disease.

Any clinical data or research information referenced on this page is derived from peer-reviewed scientific literature and official publications. This information is provided for educational reference only and does not constitute medical advice or product claims.

By purchasing this product, you acknowledge that you are a qualified researcher and agree to use it in full compliance with all applicable laws and regulations.