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Semax

Name: Semax
Brand: Peptide Titans
SKU: 655
Availability: InStock

Price range: $134.99 through $219.99

Semax is a synthetic heptapeptide derived from a fragment of adrenocorticotropic hormone (ACTH), studied for its role in neurotrophic signaling and cognitive-related pathways. In research settings, it’s explored for interactions with BDNF expression, dopaminergic modulation, and neuroprotective mechanisms within central nervous system tissues. Intended for research use only, not for human or veterinary use.

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Molecular Characteristics

Complete Specifications

CAS Registry Number: 80714-61-0
PubChem CID: Not available
Peptide Classification: Synthetic heptapeptide (ACTH(4–10) analog)
Molecular Formula: C₃₇H₅₁N₉O₁₀
Molecular Weight: ~813.86 Da

Structural Composition

Amino Acid Sequence:
Met-Glu-His-Phe-Pro-Gly-Pro
Length: 7 amino acids

Physical Properties

Appearance: White to off-white lyophilized powder
Solubility: Water, bacteriostatic water, buffered aqueous solutions (e.g., PBS)

Structural & Stability Notes

Semax is a synthetic heptapeptide derived from the ACTH(4–10) fragment sequence. Its short linear structure supports efficient aqueous solubility and laboratory handling. As a small peptide, it remains susceptible to enzymatic degradation in biological systems; therefore, lyophilized storage under cold, dry conditions is recommended. Protection from moisture, light exposure, and repeated freeze–thaw cycles helps preserve structural integrity and maintain analytical consistency during research applications.

Research Applications

Neurotrophic Signaling Research

Semax is utilized as a synthetic peptide analog of adrenocorticotropic hormone (ACTH 4–10 fragment) in research studies examining neurotrophic signaling and central nervous system regulatory pathways. Laboratory investigations focus on its role in:

Brain-Derived Neurotrophic Factor (BDNF) Models: Investigation of transcriptional pathways associated with neurotrophin expression
MAPK and ERK Cascade Studies: Evaluation of intracellular kinase activation linked to neuronal signaling
Neurotransmitter Regulation Research: Analysis of signaling mechanisms influencing dopaminergic and serotonergic systems
Synaptic Plasticity Models: Examination of intracellular pathways associated with neuronal adaptability
Peptide Stability Studies: Investigation of structural persistence and enzymatic resistance in laboratory systems

Experimental protocols commonly employ neuronal cell cultures, gene expression profiling, and intracellular signaling analyses to characterize Semax-mediated neuroregulatory responses.

Cerebral Circulation and Neurovascular Research

Semax has been examined in research contexts involving neurovascular signaling and cerebral regulatory models. Key areas of investigation include:

Endothelial Interaction Models: Evaluation of signaling pathways linking neuronal and vascular systems
Nitric Oxide Pathway Studies: Investigation of intracellular cascades associated with neurovascular regulation
Hypoxic Signaling Research: Analysis of adaptive responses within neuronal tissue models
Neuroprotective Pathway Models: Research into intracellular signaling cascades associated with cellular resilience
Blood–Brain Barrier Studies: Examination of permeability regulation within central nervous system models

These studies utilize vascular cell assays, oxidative stress biomarker profiling, and intracellular kinase analyses to evaluate neurovascular regulatory outcomes.

Cognitive Signaling and Synaptic Research

Semax has also been explored in research models examining intracellular pathways associated with synaptic signaling and neural network modulation, including:

Glutamatergic Signaling Studies: Evaluation of receptor-mediated intracellular cascades
Dopaminergic Pathway Models: Investigation of intracellular signaling mechanisms influencing neurotransmitter balance
Oxidative Stress Research: Analysis of redox-associated regulatory pathways in neuronal systems
Gene Expression Modulation Studies: Examination of transcriptional responses within neural tissues

Laboratory protocols assess neurotransmitter markers, synaptic protein expression, and intracellular kinase activation using biochemical and molecular techniques.

Cellular Signaling and Neuroregulatory Network Research

Additional research applications explore Semax’s influence on intracellular regulatory systems involved in neural coordination and central nervous system homeostasis, including:

PI3K-AKT Pathway Studies: Investigation of cascades associated with neuronal survival signaling
Transcription Factor Profiling: Analysis of regulatory responses linked to neurotrophic signaling
Receptor Sensitivity Research: Examination of adaptive signaling modulation within neuronal receptor systems
Integrated Neuroregulatory Network Models: Analysis of coordinated signaling systems maintaining neural equilibrium

Research in this domain focuses on understanding how Semax influences neurotrophic signaling pathways, neurotransmitter-associated intracellular cascades, and adaptive neuronal responses under controlled experimental conditions.

Laboratory Handling and Storage Protocols

Lyophilized Powder Storage

Store at –20°C to –80°C in the original, sealed vial
Protect from light exposure and moisture
A desiccated storage environment is recommended
Stability data suggests extended stability when stored at −20 °C or below.

Reconstitution Guidelines

Reconstitute using sterile water, bacteriostatic water (0.9% benzyl alcohol), or an appropriate laboratory buffer
Introduce solvent slowly along the vial wall to minimize foaming
Mix using gentle swirling; avoid vigorous agitation or shaking
Allow complete dissolution prior to use (typically 1–2 minutes)
Ensure the final solution is within a physiologically neutral pH range appropriate for laboratory use

Reconstituted Solution Storage

Short-term storage: Up to 7 days at 4°C
Long-term storage: Store at –20°C in aliquots
Use single-use aliquots to preserve peptide integrity
Minimize freeze–thaw cycles; single-use aliquots are strongly recommended

Stability Characteristics

Semax is a synthetic peptide research compound that demonstrates stable handling characteristics when managed according to standard peptide laboratory protocols. Proper cold storage of the lyophilized material, careful reconstitution, protection from light, and minimized freeze–thaw exposure help maintain structural integrity and solubility. When handled appropriately, Semax supports consistent use in in vitro and analytical research applications.

Frequently Asked Questions

What is Semax?

Semax is a synthetic heptapeptide derived from an ACTH fragment. It is used in research to investigate neurotrophic factor signaling and neurotransmitter pathway interactions.

What is Semax commonly researched for?

In laboratory and preclinical models, Semax is studied for:

Brain-derived neurotrophic factor (BDNF) pathway investigation
Dopaminergic and serotonergic signaling models
Neuroprotective signaling research
Stress-response pathway studies
Cognitive and behavioral research models

All applications are exploratory and conducted in controlled research environments.

Is Semax naturally occurring?

No. While derived from a naturally occurring ACTH fragment, Semax itself is a synthetically engineered peptide and does not occur naturally in this exact form.

How does Semax differ from Selank?

Semax and Selank are structurally distinct peptides studied in neuropeptide research. Semax is more commonly investigated for neurotrophic and monoaminergic pathway interactions, while Selank is often studied for GABAergic and immune-related signaling models.

How does Semax differ from N-Acetyl Semax?

N-Acetyl Semax includes an N-terminal acetyl modification, which may enhance stability and resistance to enzymatic degradation in research environments. The core peptide sequence remains related.

How is Semax supplied?

Semax is typically supplied as a lyophilized (freeze-dried) powder in sealed research vials to preserve stability during storage and shipment.

How should unreconstituted Semax be stored?

Lyophilized Semax should be stored:

Long-term: −20 °C to −80 °C
Short-term: 2–8 °C

Keep vials sealed and protected from light and moisture until use.

How should reconstituted Semax be handled and stored?

Once reconstituted:

Store at 2–8 °C for short-term laboratory use
For extended storage, aliquot and freeze at −20 °C or below
Minimize freeze–thaw cycles using single-use aliquots
Gently swirl to mix; avoid vigorous agitation

Does Semax require a Certificate of Analysis (COA)?

Yes. A Certificate of Analysis (COA) should be available for each batch, verifying peptide identity, purity, and analytical testing results to ensure research quality and traceability.

Is Semax FDA-approved?

Research-grade Semax is not FDA-approved as a drug, supplement, or therapeutic product. It is sold exclusively as a research compound and must not be marketed or used for diagnostic, therapeutic, or consumption purposes.

⚠️ Research Use Only

This product is not for human consumption. It is sold strictly for research and educational purposes and is not intended to diagnose, treat, cure, or prevent any disease.

Any clinical data or research information referenced on this page is derived from peer-reviewed scientific literature and official publications. This information is provided for educational reference only and does not constitute medical advice or product claims.

By purchasing this product, you acknowledge that you are a qualified researcher and agree to use it in full compliance with all applicable laws and regulations.