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Selank

Name: Selank
Brand: Peptide Titans
SKU: 566
Availability: InStock

Price range: $124.99 through $199.99

Selank is a synthetic heptapeptide derived from the endogenous immunomodulatory peptide tuftsin, studied for its role in neurotransmitter modulation and stress-response pathways. In research settings, it’s explored for interactions with GABAergic signaling, neurotrophic factor expression (including BDNF), and immune-related regulatory mechanisms. Intended for research use only, not for human or veterinary use.

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Molecular Characteristics

Complete Specifications

CAS Registry Number: 129954-34-3
PubChem CID: Not available
Peptide Classification: Synthetic heptapeptide (tuftsin analog)
Molecular Formula: C₃₃H₅₇N₁₁O₉
Molecular Weight: ~751.87 Da

Structural Composition

Amino Acid Sequence:
Thr-Lys-Pro-Arg-Pro-Gly-Pro
Length: 7 amino acids

Physical Properties

Appearance: White to off-white lyophilized powder
Solubility: Water, bacteriostatic water, buffered aqueous solutions (e.g., PBS)

Structural & Stability Notes

Selank is a synthetic heptapeptide derived from the endogenous immunomodulatory peptide tuftsin. Its short chain length supports efficient aqueous solubility and practical laboratory handling. As a linear peptide, it remains susceptible to enzymatic degradation in biological environments, making lyophilized storage under cold, dry conditions important for maintaining stability. Protection from moisture, light exposure, and repeated freeze–thaw cycles helps preserve structural integrity and analytical consistency during research applications.

Research Applications

Neurotransmitter and GABAergic Signaling Research

Selank is utilized as a synthetic peptide analog in research studies examining neurotransmitter regulation and GABAergic signaling pathways within central nervous system models. Laboratory investigations focus on its role in:

GABA Receptor Modulation Models: Investigation of receptor sensitivity and inhibitory signaling balance
Serotonergic Pathway Studies: Evaluation of serotonin-associated neurotransmission dynamics
Dopaminergic Signaling Research: Analysis of dopamine-related intracellular cascades
cAMP-Dependent Pathway Models: Examination of second messenger signaling following peptide exposure
Receptor Regulation Studies: Investigation of adaptive responsiveness within inhibitory neural networks

Experimental protocols commonly employ neuronal cell cultures, receptor-binding assays, and transcriptional profiling techniques to characterize Selank-mediated neuroregulatory responses.

Neurotrophic and Plasticity Research

Selank has been examined in research contexts involving neurotrophic factor modulation and synaptic plasticity models. Key areas of investigation include:

BDNF Expression Models: Evaluation of transcriptional pathways associated with neurotrophic signaling
Synaptic Transmission Studies: Investigation of neurotransmitter release and receptor regulation dynamics
CREB Pathway Research: Analysis of transcription factor activation associated with neural adaptation
Neuronal Connectivity Models: Research into intracellular signaling influencing synaptic organization
Signal Duration Analysis: Examination of peptide persistence effects on neural signaling patterns

These studies utilize gene expression assays, electrophysiological recordings, and neuronal culture systems to evaluate neuroplasticity-related signaling outcomes.

Immune–Neural Interaction Research

Selank has also been explored in research models examining cross-talk between immune signaling and central nervous system pathways, including:

Cytokine Regulation Studies: Evaluation of immune mediator signaling within neural tissues
Neuroinflammatory Pathway Models: Investigation of inflammatory cascade modulation in CNS systems
Stress Response Research: Analysis of adaptive signaling during experimental stress conditions
Immune Feedback Mechanism Studies: Examination of coordinated signaling maintaining neuroimmune balance

Laboratory protocols assess inflammatory biomarkers, neurotransmitter levels, and transcription factor activity using biochemical and molecular techniques.

Cellular Signaling and Neuroregulatory Pathway Research

Additional research applications explore Selank’s influence on intracellular regulatory systems involved in central nervous system homeostasis, including:

MAPK and ERK Pathway Studies: Investigation of downstream cascades associated with neurotrophic signaling
Gene Expression Profiling: Analysis of transcriptional responses linked to neural adaptation
Receptor Sensitivity Research: Examination of signaling modulation and adaptive receptor regulation
Integrated Neuroendocrine Network Models: Analysis of coordinated signaling systems maintaining CNS equilibrium

Research in this domain focuses on understanding how Selank influences neurotransmitter pathways, neurotrophic factor signaling, and immune–neural regulatory mechanisms under controlled experimental conditions.

Laboratory Handling and Storage Protocols

Lyophilized Powder Storage

Store at –20°C to –80°C in the original, sealed vial
Protect from light exposure and moisture
A desiccated storage environment is recommended
Stability data suggests extended stability when stored at −20 °C or below.

Reconstitution Guidelines

Reconstitute using sterile water, bacteriostatic water (0.9% benzyl alcohol), or an appropriate laboratory buffer
Introduce solvent slowly along the vial wall to minimize foaming
Mix using gentle swirling; avoid vigorous agitation or shaking
Allow complete dissolution prior to use (typically 1–2 minutes)
Ensure the final solution is within a physiologically neutral pH range appropriate for laboratory use

Reconstituted Solution Storage

Short-term storage: Up to 7 days at 4°C
Long-term storage: Store at –20°C in aliquots
Use single-use aliquots to preserve peptide integrity
Minimize freeze–thaw cycles; single-use aliquots are strongly recommended

Stability Characteristics

Selank is a synthetic peptide research compound that demonstrates stable handling characteristics when managed according to standard peptide laboratory protocols. Proper cold storage of the lyophilized material, careful reconstitution, and minimized freeze–thaw exposure help maintain structural integrity and solubility. When handled appropriately, Selank supports consistent use in in vitro and analytical research applications.

Frequently Asked Questions

What is Selank?

Selank is a synthetic seven–amino acid peptide developed for experimental research into neurotransmitter signaling and neuroimmune regulatory pathways.

What is Selank commonly researched for?

In laboratory and preclinical models, Selank is studied for:

GABAergic signaling pathway investigation
Neuropeptide receptor interaction research
Cytokine and immune signaling modulation models
Stress-response pathway studies
Cognitive and behavioral research models

All applications are exploratory and conducted in controlled research environments.

Is Selank naturally occurring?

No. Selank is a synthetically engineered peptide, although it is structurally derived from tuftsin-related research. It does not occur naturally in this exact form.

How does Selank differ from Semax?

Selank and Semax are structurally distinct peptides studied in neuropeptide research. Selank is commonly investigated for GABAergic and immune-related signaling models, while Semax is more often studied for neurotrophic factor and monoaminergic pathway interactions.

How is Selank supplied?

Selank is typically supplied as a lyophilized (freeze-dried) powder in sealed research vials to preserve stability during storage and shipment.

How should unreconstituted Selank be stored?

Lyophilized Selank should be stored:

Long-term: −20 °C to −80 °C
Short-term: 2–8 °C

Keep vials sealed and protected from light and moisture until use.

How should reconstituted Selank be handled and stored?

Once reconstituted:

Store at 2–8 °C for short-term laboratory use
For extended storage, aliquot and freeze at −20 °C or below
Minimize freeze–thaw cycles using single-use aliquots
Gently swirl to mix; avoid vigorous agitation

Does Selank require a Certificate of Analysis (COA)?

Yes. A Certificate of Analysis (COA) should be available for each batch, verifying peptide identity, purity, and analytical testing results to ensure research quality and traceability.

Is Selank FDA-approved?

No. Selank is not FDA-approved as a drug, supplement, or therapeutic product. It is sold exclusively as a research compound and must not be marketed or used for diagnostic, therapeutic, or consumption purposes.

⚠️ Research Use Only

This product is not for human consumption. It is sold strictly for research and educational purposes and is not intended to diagnose, treat, cure, or prevent any disease.

Any clinical data or research information referenced on this page is derived from peer-reviewed scientific literature and official publications. This information is provided for educational reference only and does not constitute medical advice or product claims.

By purchasing this product, you acknowledge that you are a qualified researcher and agree to use it in full compliance with all applicable laws and regulations.