Molecular Characteristics
Complete Specifications
Structural Composition
Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
Physical Properties
MOTS-c is a 16-amino-acid peptide encoded within mitochondrial DNA and synthesized as a short mitochondrial-derived peptide. Its compact structure supports aqueous solubility and practical handling under laboratory conditions. The peptide contains multiple basic residues contributing to overall positive charge at physiological pH. As with other short peptides, lyophilized storage and protection from moisture, light exposure, and repeated freeze–thaw cycles help preserve structural integrity and analytical consistency during research applications.
Analysis & Documentation
Identity
Each production lot is checked against the reference structure recorded for this compound:
- Classification — Synthetic 16-amino-acid mitochondrial-derived peptide
- Molecular formula — C₁₀₁H₁₅₂N₂₈O₂₂
- Expected mass — ~2,174.6 Da
- CAS registry — Not assigned (mitochondrial-derived peptide)
- Chain length — 16 amino acids
- PubChem CID — Not available
Analytical Methods
Testing is carried out per lot by an independent laboratory. The methods measure what the material is and how much of it is the target compound:
- RP-HPLC — reverse-phase separation of the target from process-related impurities; purity is reported as area percent of the main peak
- Mass spectrometry — observed mass compared against the expected molecular mass above
- Retention time — compared against a reference standard run under the same conditions
- Chromatogram — reproduced on the certificate so the peak and any shoulders can be inspected directly
Material & Documentation
What arrives, and how to tie it back to its paperwork:
- Appearance as supplied — White to off-white lyophilized powder
- Solubility — Water, buffered aqueous solutions (e.g., PBS)
- Lot number — printed on the container label and used to look up the certificate
- Certificate — indexed by lot at Certificates of Analysis
Laboratory Handling and Storage Protocols
Lyophilized Powder Storage
- Store at –20°C to –80°C in the original, sealed vial
- Protect from light exposure and moisture
- A desiccated storage environment is recommended
- Stability data suggests extended stability when stored at −20 °C or below.
Reconstituted Solution Storage
- Short-term storage: Up to 7 days at 4°C
- Long-term storage: Store at –20°C in aliquots
- Use single-use aliquots to preserve peptide integrity
- Minimize freeze–thaw cycles; single-use aliquots are strongly recommended
Stability Characteristics
MOTS-c is a synthetic mitochondrial-derived peptide research compound that demonstrates stable handling characteristics when managed according to standard peptide laboratory protocols. Proper cold storage of the lyophilized material, careful reconstitution, and minimized freeze–thaw exposure help preserve structural integrity and solubility. When handled appropriately, MOTS-c supports consistent use in in vitro and analytical research applications.
Frequently Asked Questions
What is MOTS-c?
MOTS-c is a short peptide encoded within mitochondrial DNA and classified as a mitochondrial-derived peptide (MDP). It is used in research to investigate mitochondrial communication and metabolic signaling pathways.
Is MOTS-c a naturally occurring peptide?
Yes. MOTS-c is naturally encoded within mitochondrial DNA. Synthetic MOTS-c used in research replicates this endogenous peptide sequence for experimental investigation.
How does MOTS-c differ from traditional peptides?
Unlike nuclear DNA–encoded peptides, MOTS-c is derived from mitochondrial DNA. It is supplied as a lyophilized powder for laboratory use, with identity and purity reported per lot on the Certificate of Analysis.
MOTS-c is typically supplied as a lyophilized (freeze-dried) powder in sealed research vials to preserve stability during storage and shipment. Lyophilized MOTS-c should be stored: Long-term: −20 °C to −80 °C Short-term: 2–8 °C Keep vials sealed and protected from light and moisture until use. Once reconstituted: Store at 2–8 °C for short-term laboratory use For extended storage, aliquot and freeze at −20 °C or below Minimize freeze–thaw cycles using single-use aliquots Gently swirl to mix; avoid vigorous agitation Yes. A Certificate of Analysis (COA) should be available for each batch of MOTS-c, verifying identity and purity to ensure research quality and traceability. No. MOTS-c is not FDA-approved as a drug, supplement, or therapeutic product. It is sold exclusively as a research compound and must not be marketed or used for diagnostic, therapeutic, or consumption purposes.How is MOTS-c supplied?
How should unreconstituted MOTS-c be stored?
How should reconstituted MOTS-c be handled and stored?
Does MOTS-c require a Certificate of Analysis (COA)?
Is MOTS-c FDA-approved?
This product is not for human consumption. It is sold strictly for research and educational purposes and is not intended to diagnose, treat, cure, or prevent any disease.
Any clinical data or research information referenced on this page is derived from peer-reviewed scientific literature and official publications. This information is provided for educational reference only and does not constitute medical advice or product claims.
By purchasing this product, you acknowledge that you are a qualified researcher and agree to use it in full compliance with all applicable laws and regulations.
| Mg | 10 mg, 20 mg, 40 mg, 10 mg x 10 Vials (No Labels), 20 mg x 10 Vials (No Labels) |
|---|---|
| Research Category |
