Molecular Characteristics
Complete Specifications
Structural Composition
Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂
Physical Properties
Kisspeptin-10 is a synthetic decapeptide corresponding to the C-terminal active fragment of the larger kisspeptin peptide family. The C-terminal amidation enhances structural stability and receptor-binding conformation under controlled research conditions. As a short-chain peptide, it is susceptible to enzymatic degradation in biological environments, making lyophilized storage and cold-chain handling important for preserving structural integrity. Protection from moisture, light exposure, and repeated freeze–thaw cycles helps maintain analytical consistency during laboratory applications.
Analysis & Documentation
Identity
Each production lot is checked against the reference structure recorded for this compound:
- Classification — Synthetic decapeptide (C-terminal fragment of metastin/kisspeptin-54)
- Molecular formula — C₆₃H₈₃N₁₇O₁₄
- Expected mass — ~1,302.5 Da
- CAS registry — 374675-21-5
- Chain length — 10 amino acids
- PubChem CID — Not available
Analytical Methods
Testing is carried out per lot by an independent laboratory. The methods measure what the material is and how much of it is the target compound:
- RP-HPLC — reverse-phase separation of the target from process-related impurities; purity is reported as area percent of the main peak
- Mass spectrometry — observed mass compared against the expected molecular mass above
- Retention time — compared against a reference standard run under the same conditions
- Chromatogram — reproduced on the certificate so the peak and any shoulders can be inspected directly
Material & Documentation
What arrives, and how to tie it back to its paperwork:
- Appearance as supplied — White to off-white lyophilized powder
- Solubility — Water, buffered aqueous solutions (e.g., PBS)
- Lot number — printed on the container label and used to look up the certificate
- Certificate — indexed by lot at Certificates of Analysis
Laboratory Handling and Storage Protocols
Lyophilized Powder Storage
- Store at –20°C to –80°C in the original, sealed vial
- Protect from light exposure and moisture
- A desiccated storage environment is recommended
- Stability data suggests extended stability when stored at −20 °C or below.
Reconstituted Solution Storage
- Short-term storage: Up to 7 days at 4°C
- Long-term storage: Store at –20°C in aliquots
- Use single-use aliquots to preserve peptide integrity
- Minimize freeze–thaw cycles; single-use aliquots are strongly recommended
Stability Characteristics
Kisspeptin-10 is a synthetic peptide research compound that demonstrates stable handling characteristics when managed according to standard peptide laboratory protocols. Proper cold storage of the lyophilized material, careful reconstitution, and minimized freeze–thaw exposure help preserve structural integrity and solubility. When handled appropriately, Kisspeptin-10 supports consistent use in in vitro and analytical research applications.
Frequently Asked Questions
What is Kisspeptin-10?
Kisspeptin-10 is a 10–amino acid peptide fragment representing the active core sequence of longer kisspeptin peptides. It is used in research to investigate reproductive endocrine signaling and GnRH regulation pathways.
Is Kisspeptin-10 the same as full-length Kisspeptin-54?
No. Kisspeptin-10 is a shorter fragment derived from longer kisspeptin peptides such as Kisspeptin-54. While it contains the biologically active core region, it differs in length and stability characteristics in research models.
How does Kisspeptin-10 differ from Gonadorelin?
Kisspeptin-10 acts upstream in endocrine signaling by stimulating GnRH neuron activation, whereas Gonadorelin is a synthetic form of GnRH itself. Their positions within the reproductive signaling cascade differ in research models.
How is Kisspeptin-10 supplied?
Kisspeptin-10 is typically supplied as a lyophilized (freeze-dried) powder in sealed research vials to preserve stability during storage and transport.
How should unreconstituted Kisspeptin-10 be stored?
Lyophilized Kisspeptin-10 should be stored:
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Long-term: −20 °C to −80 °C
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Short-term: 2–8 °C
Keep vials sealed and protected from light and moisture until use.
How should reconstituted Kisspeptin-10 be handled and stored?
Once reconstituted:
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Store at 2–8 °C for short-term laboratory use
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For extended storage, aliquot and freeze at −20 °C or below
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Minimize freeze–thaw cycles using single-use aliquots
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Gently swirl to mix; avoid vigorous agitation
Does Kisspeptin-10 require a Certificate of Analysis (COA)?
Yes. A Certificate of Analysis (COA) should be available for each batch of Kisspeptin-10, verifying identity, purity, and analytical testing results to ensure research quality and traceability.
Is Kisspeptin-10 FDA-approved?
No. Kisspeptin-10 is not FDA-approved as a drug, supplement, or therapeutic product. It is sold exclusively as a research compound and must not be marketed or used for diagnostic, therapeutic, or consumption purposes.
Research Background
For a referenced overview of what the published research on this compound examines — and what it does not establish — see What Is Kisspeptin? Research Background and Study Areas. It cites peer-reviewed sources and contains no dosing guidance.
This product is not for human consumption. It is sold strictly for research and educational purposes and is not intended to diagnose, treat, cure, or prevent any disease.
Any clinical data or research information referenced on this page is derived from peer-reviewed scientific literature and official publications. This information is provided for educational reference only and does not constitute medical advice or product claims.
By purchasing this product, you acknowledge that you are a qualified researcher and agree to use it in full compliance with all applicable laws and regulations.
