Spend {{difference_amount}} more and get 15% discount

Test

Sale!

Ipamorelin

Name: Ipamorelin
Brand: Peptide Titans
SKU: 536
Availability: InStock

Price range: $174.99 through $329.99

Ipamorelin is a synthetic pentapeptide classified as a selective growth hormone secretagogue, studied for its ability to stimulate growth hormone release via activation of the ghrelin (GHS-R1a) receptor. In research settings, it’s explored for effects on IGF-1 signaling, metabolic regulation, and tissue-related pathways, with comparatively minimal activity on other pituitary hormones. Intended for research use only, not for human or veterinary use.

Clear

Molecular Characteristics

Complete Specifications

CAS Registry Number: 170851-70-4
PubChem CID: Not available
Peptide Classification: Synthetic pentapeptide (growth hormone–releasing peptide)
Molecular Formula: C₃₈H₄₉N₉O₅
Molecular Weight: ~711.85 Da

Structural Composition

Amino Acid Sequence:
Aib-His-D-2-Nal-D-Phe-Lys-NH₂
Length: 5 amino acids

Physical Properties

Appearance: White to off-white lyophilized powder
Solubility: Water, bacteriostatic water, phosphate-buffered saline (PBS)

Structural & Stability Notes

Ipamorelin is a synthetic pentapeptide containing non-natural amino acid residues such as Aib (α-aminoisobutyric acid) and D-configured aromatic residues, which enhance resistance to enzymatic degradation compared to peptides composed solely of L-amino acids. These structural modifications contribute to improved stability under controlled research conditions. Its short chain length supports efficient aqueous solubility and practical laboratory handling. Lyophilized storage and protection from moisture, light exposure, and repeated freeze–thaw cycles help preserve peptide integrity and maintain analytical consistency during research applications.

Research Applications

Growth Hormone Secretagogue Research

Ipamorelin is utilized as a research compound in studies examining growth hormone secretagogue receptor (GHS-R1a) activation and selective endocrine signaling pathways. Laboratory investigations focus on its role in:

Ghrelin Receptor Activation Models: Investigation of receptor binding dynamics and downstream intracellular signaling cascades
Pulsatile Growth Hormone Release Studies: Evaluation of transient hormone secretion patterns under experimental conditions
Calcium-Dependent Signaling Research: Analysis of intracellular calcium mobilization following receptor engagement
Selective Endocrine Modulation: Examination of receptor specificity and limited off-target hormonal interactions
Receptor Sensitivity Studies: Investigation of signaling amplitude and desensitization characteristics

Experimental protocols commonly employ receptor-binding assays, pituitary cell culture systems, and endocrine monitoring models to characterize Ipamorelin-mediated signaling responses.

Endocrine and Metabolic Research

Ipamorelin has been extensively studied in research models examining endocrine regulation and metabolic signaling pathways. Key areas of investigation include:

Insulin-Like Growth Factor (IGF) Pathway Models: Evaluation of downstream signaling associated with growth hormone stimulation
Glucose and Lipid Interaction Studies: Investigation of metabolic cross-regulation following secretagogue activation
Energy Utilization Models: Analysis of systemic substrate usage under altered endocrine signaling
Hormonal Feedback Loop Research: Examination of regulatory mechanisms maintaining pituitary balance
Pulse Pattern Optimization Models: Research into timing-dependent variations in endocrine output

These studies utilize endocrine profiling systems, metabolic assays, and longitudinal hormone monitoring to evaluate signaling outcomes.

Muscle and Tissue Signaling Research

Ipamorelin has also been explored in research models examining anabolic signaling and tissue adaptation mechanisms, including:

Protein Synthesis Pathway Studies: Evaluation of intracellular cascades associated with growth-related signaling
Myoblast Differentiation Models: Investigation of muscle precursor cell proliferation and maturation processes
Extracellular Matrix Interaction Research: Analysis of tissue remodeling signaling dynamics
Regenerative Cell Population Studies: Examination of cellular adaptation under endocrine modulation

Laboratory protocols assess molecular markers, cellular growth patterns, and anabolic signaling activity using biochemical and imaging-based techniques.

Cellular Signaling and Endocrine Homeostasis Research

Additional research applications explore Ipamorelin’s influence on intracellular regulatory systems involved in endocrine stability and growth-related signaling, including:

MAPK and PI3K-AKT Pathway Studies: Investigation of downstream cascades associated with growth hormone stimulation
Gene Expression Profiling: Analysis of transcriptional responses following receptor activation
Calcium Signaling Regulation: Research into intracellular calcium dynamics associated with secretagogue pathways
Endocrine Feedback Systems: Examination of regulatory networks preserving hormonal equilibrium

Research in this domain focuses on understanding how Ipamorelin influences ghrelin receptor signaling, pulsatile endocrine dynamics, and growth-related cellular pathways under controlled experimental conditions.

Laboratory Handling and Storage Protocols

Lyophilized Powder Storage

Store at –20°C to –80°C in the original, sealed vial
Protect from light exposure and moisture
A desiccated storage environment is recommended
Stability data suggests extended stability when stored at −20 °C or below.

Reconstitution Guidelines

Reconstitute using sterile water, bacteriostatic water (0.9% benzyl alcohol), or an appropriate laboratory buffer
Introduce solvent slowly along the vial wall to minimize foaming
Mix using gentle swirling; avoid vigorous agitation or shaking
Allow complete dissolution prior to use (typically 1–2 minutes)
Ensure the final solution is within a physiologically neutral pH range appropriate for laboratory use

Reconstituted Solution Storage

Short-term storage: Up to 7 days at 4°C
Long-term storage: Store at –20°C in aliquots
Use single-use aliquots to preserve peptide integrity
Minimize freeze–thaw cycles; single-use aliquots are strongly recommended

Stability Characteristics

Ipamorelin is a synthetic peptide research compound that demonstrates stable handling characteristics when managed according to standard peptide laboratory protocols. Proper cold storage of the lyophilized material, careful reconstitution, and minimized freeze–thaw exposure help preserve structural integrity and solubility. When handled appropriately, Ipamorelin supports consistent use in in vitro and analytical research applications.

Frequently Asked Questions

What is Ipamorelin?

Ipamorelin is a synthetic five–amino acid peptide designed to activate the GHS-R1a receptor in experimental models. It is commonly used in laboratory research focused on growth hormone signaling mechanisms.

What is Ipamorelin commonly researched for?

In controlled laboratory and preclinical models, Ipamorelin is studied for:

Growth hormone release signaling
Ghrelin receptor (GHS-R1a) activation
IGF-1 pathway investigation
Endocrine and metabolic pathway research

All applications are exploratory and conducted in research settings.

How does Ipamorelin differ from other GHRPs?

Ipamorelin is structurally distinct from peptides such as GHRP-2, GHRP-6, and Hexarelin. In research models, it is often noted for its receptor selectivity, which may influence downstream signaling characteristics compared to other growth hormone secretagogues.

Is Ipamorelin the same as GHRH analogs like CJC-1295?

No. Ipamorelin primarily activates the ghrelin receptor (GHS-R1a), whereas GHRH analogs such as CJC-1295 act through the GHRH receptor. While both are studied in growth hormone–related research, their mechanisms differ.

How is Ipamorelin supplied?

Ipamorelin is typically supplied as a lyophilized (freeze-dried) powder in sealed research vials to maintain stability during storage and shipment.

How should unreconstituted Ipamorelin be stored?

Lyophilized Ipamorelin should be stored:

Long-term: −20 °C to −80 °C
Short-term: 2–8 °C

Keep vials sealed and protected from light and moisture until use.

How should reconstituted Ipamorelin be handled and stored?

Once reconstituted:

Store at 2–8 °C for short-term laboratory use
For extended storage, aliquot and freeze at −20 °C or below
Minimize freeze–thaw cycles using single-use aliquots
Gently swirl to mix; avoid vigorous agitation

Does Ipamorelin require a Certificate of Analysis (COA)?

Yes. A Certificate of Analysis (COA) should be available for each batch, verifying peptide identity, purity, and analytical testing results to ensure research quality and traceability.

Is Ipamorelin FDA-approved?

No. Ipamorelin is not FDA-approved as a drug, supplement, or therapeutic product. It is sold exclusively as a research compound and must not be marketed or used for diagnostic, therapeutic, or consumption purposes.

⚠️ Research Use Only

This product is not for human consumption. It is sold strictly for research and educational purposes and is not intended to diagnose, treat, cure, or prevent any disease.

Any clinical data or research information referenced on this page is derived from peer-reviewed scientific literature and official publications. This information is provided for educational reference only and does not constitute medical advice or product claims.

By purchasing this product, you acknowledge that you are a qualified researcher and agree to use it in full compliance with all applicable laws and regulations.