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GLP-3(R)

Name: GLP-3(R)
Brand: Peptide Titans
SKU: 585
Availability: InStock

Price range: $349.99 through $839.99

GLP-3(R) is a synthetic triple-receptor agonist studied for its activity at GLP-1, GIP, and glucagon receptors, targeting complex metabolic signaling pathways. In research settings, it’s explored for its potential influence on energy balance, glucose regulation, appetite-related signaling, and multi-hormonal metabolic mechanisms. Intended for research use only, not for human or veterinary use.

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Description
Additional information

Molecular Characteristics

Complete Specifications

CAS Registry Number: Not assigned (investigational modified peptide)
PubChem CID: Not available
Peptide Classification: Synthetic triple agonist peptide (GLP-1 / GIP / glucagon receptor analog)
Molecular Formula: Variable (lipidated modified peptide)
Molecular Weight: ~4,700–5,000 Da (approximate, modification-dependent)

Structural Composition

Amino Acid Sequence:
Modified incretin/glucagon hybrid peptide with targeted amino acid substitutions and fatty-acid side-chain conjugation for enhanced structural persistence
Length: ~39 amino acids (modified, lipidated)

Physical Properties

Appearance: White to off-white lyophilized powder
Solubility: Water, bacteriostatic water, buffered aqueous solutions (e.g., PBS)

Structural & Stability Notes

GLP-3(R) is a modified peptide engineered as a triple receptor agonist analog structurally related to GLP-1, GIP, and glucagon receptor peptides. Strategic amino acid substitutions and lipidation enhance resistance to enzymatic degradation under research conditions and contribute to extended structural persistence compared to non-lipidated peptides. The presence of a fatty-acid side chain supports reversible binding to circulating proteins, increasing molecular stability. Lyophilized storage and protection from moisture, light exposure, and repeated freeze–thaw cycles help preserve structural integrity and analytical consistency for laboratory applications.

Research Applications

Triple Incretin Receptor Signaling Research

GLP-3(R) is utilized as a triple receptor agonist in research studies examining glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptor–associated signaling pathways. Laboratory investigations focus on its role in:

GLP-1 Receptor Activation Models: Investigation of receptor binding dynamics and intracellular cAMP-mediated cascades
GIP Receptor Signaling Studies: Evaluation of incretin-associated intracellular pathways influencing metabolic regulation
Glucagon Receptor Research: Analysis of hepatic-associated signaling cascades and substrate utilization pathways
cAMP and PKA Pathway Models: Examination of second messenger amplification following multi-receptor activation
Receptor Selectivity and Stability Studies: Investigation of structural persistence and binding affinity across receptor subtypes

Experimental protocols commonly employ receptor-binding assays, intracellular kinase activation analyses, and metabolic cell models to characterize GLP-3(R)–mediated signaling responses.

Metabolic Regulation and Energy Balance Research

GLP-3(R) has been examined in research contexts involving coordinated metabolic signaling networks and systemic energy regulation models. Key areas of investigation include:

Pancreatic Beta-Cell Signaling Models: Evaluation of intracellular cascades influencing insulin-associated pathways
Hepatic Glucose Output Studies: Investigation of glucagon receptor–mediated metabolic signaling
Adipocyte Signaling Research: Analysis of intracellular pathways influencing lipid mobilization models
Energy Expenditure Models: Research into coordinated signaling affecting substrate utilization
Appetite-Regulating Circuit Studies: Examination of hypothalamic signaling pathways under laboratory conditions

These studies utilize hormone quantification assays, metabolic profiling systems, and intracellular signaling analyses to evaluate systemic metabolic regulatory outcomes.

Liver and Lipid Metabolism Research

GLP-3(R) has also been explored in research models examining hepatic signaling and lipid-associated regulatory mechanisms, including:

Hepatocyte Signaling Studies: Evaluation of intracellular pathways regulating glucose and fatty acid metabolism
AMPK Pathway Models: Investigation of energy-sensing cascades associated with metabolic balance
Fatty Acid Oxidation Research: Analysis of signaling mechanisms influencing substrate utilization
Metabolic Stress Adaptation Studies: Examination of regulatory responses to energy fluctuation models

Laboratory protocols assess metabolic enzyme activity, transcriptional markers, and intracellular kinase signaling using biochemical and molecular techniques.

Cellular Signaling and Incretin Network Research

Additional research applications explore GLP-3(R)’s influence on intracellular regulatory systems involved in coordinated incretin and glucagon receptor networks, including:

MAPK and ERK Pathway Studies: Investigation of downstream cascades associated with receptor-mediated signaling
Gene Expression Profiling: Analysis of transcriptional responses linked to metabolic regulatory systems
Receptor Sensitivity Research: Examination of adaptive signaling modulation across multi-receptor activation models
Integrated Endocrine Feedback Models: Analysis of coordinated hormonal signaling pathways maintaining metabolic equilibrium

Research in this domain focuses on understanding how GLP-3(R) influences GLP-1, GIP, and glucagon receptor–mediated signaling pathways, systemic metabolic regulatory networks, and adaptive cellular responses under controlled experimental conditions.

Laboratory Handling and Storage Protocols

Lyophilized Powder Storage

Store at –20°C to –80°C in the original, sealed vial
Protect from light exposure and moisture
A desiccated storage environment is recommended
Stability data suggests extended stability when stored at −20 °C or below.

Reconstitution Guidelines

Reconstitute using sterile water, bacteriostatic water (0.9% benzyl alcohol), or an appropriate laboratory buffer
Introduce solvent slowly along the vial wall to minimize foaming
Mix using gentle swirling; avoid vigorous agitation or shaking
Allow complete dissolution prior to use (typically 1–2 minutes)
Target a final solution pH of 7.0–8.0 for optimal stability

Reconstituted Solution Storage

Short-term storage: Up to 7 days at 4°C
Long-term storage: Store at –20°C in aliquots
Use single-use aliquots to preserve peptide integrity
Minimize freeze–thaw cycles; single-use aliquots are strongly recommended

Stability Characteristics

GLP-3(R) is a synthetic modified multi-receptor peptide research compound designed with extended structural features. Stability depends on proper cold storage of the lyophilized material, protection from light, careful reconstitution, and minimized freeze–thaw exposure. When handled according to standard peptide laboratory protocols, GLP-3(R) maintains structural integrity and solubility suitable for in vitro and analytical research applications.

Frequently Asked Questions

What is GLP-3(R)?

GLP-3(R) is a synthetic peptide analog designed to interact with three metabolic hormone receptors: GLP-1, GIP, and glucagon receptors. It is studied for coordinated multi-pathway receptor signaling.

What is GLP-3(R) commonly researched for?

In laboratory and preclinical models, GLP-3(R) is studied for:

GLP-1 receptor activation research
GIP receptor pathway investigations
Glucagon receptor signaling models
Multi-receptor metabolic pathway analysis
Energy regulation and endocrine signaling research

All applications are exploratory and conducted in controlled research environments.

How does GLP-3(R) differ from single-receptor GLP-1 analogs?

Unlike compounds that selectively activate only the GLP-1 receptor, GLP-3(R) is studied as a triple agonist, targeting GLP-1, GIP, and glucagon receptors simultaneously in research models. This enables investigation of integrated receptor pathway interactions.

Is GLP-3(R) the same as Semaglutide or Tirzepatide?

No. While all are studied in metabolic pathway research, GLP-3(R) differs structurally and functionally:

Semaglutide: GLP-1 receptor agonist
Tirzepatide: Dual GLP-1/GIP agonist
GLP-3(R): Triple GLP-1/GIP/Glucagon receptor agonist

Each compound has distinct receptor interaction profiles in experimental models.

Is GLP-3(R) a peptide?

Yes. GLP-3(R) is a synthetic peptide analog developed for receptor-targeted metabolic research.

How is GLP-3(R) supplied?

GLP-3(R) is typically supplied as a lyophilized (freeze-dried) powder in sealed research vials to maintain stability during storage and shipment.

How should unreconstituted GLP-3(R) be stored?

Lyophilized GLP-3(R) should be stored:

Long-term: −20 °C to −80 °C
Short-term: 2–8 °C

Keep vials sealed and protected from light and moisture until use.

How should reconstituted GLP-3(R) be handled and stored?

Once reconstituted:

Store at 2–8 °C for short-term laboratory use
For extended storage, aliquot and freeze at −20 °C or below
Minimize freeze–thaw cycles using single-use aliquots
Gently swirl to mix; avoid vigorous agitation

Does GLP-3(R) require a Certificate of Analysis (COA)?

Yes. A Certificate of Analysis (COA) should be available for each batch, verifying peptide identity, purity, and analytical testing results to ensure research quality and traceability.

Is GLP-3(R) FDA-approved?

When sold as a research compound, GLP-3(R) is not FDA-approved for diagnostic, therapeutic, or consumption purposes and must be marketed strictly for laboratory research use.

⚠️ Research Use Only

This product is not for human consumption. It is sold strictly for research and educational purposes and is not intended to diagnose, treat, cure, or prevent any disease.

Any clinical data or research information referenced on this page is derived from peer-reviewed scientific literature and official publications. This information is provided for educational reference only and does not constitute medical advice or product claims.

By purchasing this product, you acknowledge that you are a qualified researcher and agree to use it in full compliance with all applicable laws and regulations.