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CJC-1295 with DAC

Name: CJC-1295 with DAC
Brand: Peptide Titans
SKU: 523
Availability: InStock

Price range: $199.99 through $389.99

CJC-1295 (with DAC) is a synthetic growth hormone–releasing hormone (GHRH) analog modified with a Drug Affinity Complex (DAC) to extend its half-life. In research settings, it’s studied for its ability to sustain growth hormone and IGF-1 elevation over longer periods compared to non-DAC versions. Intended for research use only, not for human or veterinary use.

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Molecular Characteristics

Complete Specifications

CAS Registry Number: 863288-34-0
PubChem CID: Not available
Peptide Classification: Synthetic growth hormone–releasing factor (GRF 1–29) analog with Drug Affinity Complex (DAC)
Molecular Formula: C₁₆₅H₂₆₉N₄₇O₄₆
Molecular Weight: ~3,849.3 Da

Structural Composition

Amino Acid Sequence:
Modified 29-amino-acid GRF (1–29) sequence with targeted substitutions and a lysine-linked Drug Affinity Complex (maleimidopropionic acid modification)
Length: 29 amino acids (modified, DAC-conjugated)

Physical Properties

Appearance: White to off-white lyophilized powder
Solubility: Water, bacteriostatic water, phosphate-buffered saline (PBS)

Structural & Stability Notes

CJC-1295 (with DAC) is a modified 29-amino-acid peptide derived from growth hormone–releasing factor (GRF 1–29) and conjugated to a Drug Affinity Complex (DAC). The DAC moiety enables covalent binding to circulating proteins under research conditions, enhancing structural persistence compared to non-DAC variants. Targeted amino acid substitutions improve resistance to enzymatic degradation, while lyophilized presentation supports long-term storage stability. Protection from moisture, light, and repeated freeze–thaw cycles helps maintain peptide integrity for laboratory and analytical applications.

Research Applications

Growth Hormone Releasing Hormone (GHRH) Research

CJC-1295 (with DAC) is utilized as a research compound in studies examining prolonged growth hormone–releasing hormone (GHRH) receptor signaling and sustained endocrine modulation. Laboratory investigations focus on its role in:

GHRH Receptor Activation Models: Investigation of receptor binding dynamics and extended downstream signaling cascades
Sustained Growth Hormone Signaling: Evaluation of prolonged hormone release patterns under experimental conditions
cAMP and Secondary Messenger Pathways: Analysis of intracellular signaling mechanisms triggered by long-acting receptor engagement
Endocrine Feedback Regulation: Examination of pituitary and hypothalamic feedback loops during sustained stimulation
Drug Affinity Complex (DAC) Binding Studies: Investigation of albumin binding and extended circulation time characteristics

Experimental protocols commonly employ receptor-binding assays, pituitary cell culture systems, and longitudinal hormone secretion models to characterize CJC-1295 (with DAC)–mediated signaling responses.

Endocrine and Metabolic Research

CJC-1295 (with DAC) has been extensively studied in research models examining endocrine regulation and systemic metabolic signaling. Key areas of investigation include:

Insulin-Like Growth Factor (IGF) Pathway Models: Evaluation of downstream signaling associated with prolonged growth hormone stimulation
Protein Synthesis Signaling Research: Investigation of intracellular anabolic pathway activation
Lipid and Glucose Metabolism Studies: Analysis of metabolic regulation under sustained endocrine signaling
Energy Utilization and Substrate Switching: Research into systemic energy balance mechanisms
Hormone Exposure Duration Models: Examination of physiological responses to extended hormonal stimulation

This body of research utilizes endocrine profiling systems, metabolic assays, and long-term hormone monitoring models to evaluate sustained signaling effects.

Pharmacokinetics and Extended Signal Duration Research

CJC-1295 (with DAC) is also examined in studies focused on long-acting peptide kinetics and signal persistence, including:

Albumin Binding Dynamics: Evaluation of Drug Affinity Complex interactions with plasma proteins
Signal Onset and Duration Studies: Investigation of extended receptor activation compared to short-acting analogs
Plasma Stability Analysis: Research into degradation kinetics and systemic persistence in laboratory models
Comparative Pharmacodynamic Profiles: Examination of sustained endocrine activation patterns

Laboratory protocols assess circulation time, receptor occupancy, and hormonal response curves using biochemical and analytical methodologies.

Cellular Signaling and Growth Pathway Research

Additional research applications explore CJC-1295 (with DAC)’s influence on intracellular growth-related signaling systems, including:

MAPK and PI3K-AKT Pathway Studies: Investigation of downstream cascades associated with prolonged growth hormone signaling
Gene Expression Profiling: Analysis of transcriptional responses under sustained endocrine stimulation
Cellular Adaptation Mechanisms: Research into tissue responses to extended hormone exposure
Homeostatic Feedback Systems: Examination of regulatory pathways maintaining endocrine balance

Research in this domain focuses on understanding how CJC-1295 (with DAC) modulates prolonged GHRH receptor signaling, endocrine dynamics, and downstream growth-related pathways under controlled experimental conditions.

Laboratory Handling and Storage Protocols

Lyophilized Powder Storage

Store at –20°C to –80°C in the original, sealed vial
Protect from light exposure and moisture
A desiccated storage environment is recommended
Stability data suggests extended stability when stored at −20 °C or below.

Reconstitution Guidelines

Reconstitute using sterile water, bacteriostatic water (0.9% benzyl alcohol), or an appropriate laboratory buffer
Introduce solvent slowly along the vial wall to minimize foaming
Mix using gentle swirling; avoid vigorous agitation or shaking
Allow complete dissolution prior to use (typically 1–2 minutes)
Ensure the final solution is within a physiologically neutral pH range appropriate for laboratory use

Reconstituted Solution Storage

Short-term storage: Up to 7 days at 4°C
Long-term storage: Store at –20°C in aliquots
Use single-use aliquots to preserve peptide integrity
Minimize freeze–thaw cycles; single-use aliquots are strongly recommended

Stability Characteristics

CJC-1295 (with DAC) is a modified synthetic peptide research compound designed for enhanced stability through Drug Affinity Complex (DAC) attachment. When handled under standard peptide laboratory protocols, including proper cold storage and careful reconstitution, it maintains structural integrity and solubility. Minimizing mechanical agitation and freeze–thaw exposure supports consistent performance in in vitro and analytical research applications.

Frequently Asked Questions

What is CJC-1295 (with DAC)?

CJC-1295 (with DAC) is a modified GHRH analog designed for extended activity in laboratory and preclinical models. The DAC modification allows prolonged receptor interaction in research settings.

What does the DAC modification do?

The Drug Affinity Complex (DAC) enables the peptide to bind to serum albumin in research models. This binding extends its circulation time and activity duration compared to the No DAC version.

What is CJC-1295 (with DAC) commonly researched for?

In experimental research environments, it is studied for:

GHRH receptor activation
Growth hormone release dynamics
IGF-1 pathway investigation
Endocrine and metabolic signaling research

All applications are exploratory and conducted in controlled laboratory or preclinical settings.

How does CJC-1295 (with DAC) differ from CJC-1295 (No DAC)?

The key difference is the presence of the DAC modification. The DAC version is engineered for extended activity duration, while the No DAC version has a shorter activity profile in comparative research models.

How is CJC-1295 (with DAC) supplied?

CJC-1295 (with DAC) is typically supplied as a lyophilized (freeze-dried) powder in sealed research vials to maintain stability during storage and transport.

How should unreconstituted CJC-1295 (with DAC) be stored?

Lyophilized peptide should be stored:

Long-term: −20 °C to −80 °C
Short-term: 2–8 °C

Keep vials sealed and protected from light and moisture.

How should reconstituted CJC-1295 (with DAC) be handled and stored?

Once reconstituted:

Store at 2–8 °C for short-term laboratory use
For longer-term storage, aliquot and freeze at −20 °C or below
Minimize freeze–thaw cycles using single-use aliquots
Gently swirl to mix; avoid vigorous agitation

Does CJC-1295 (with DAC) require a Certificate of Analysis (COA)?

Yes. A Certificate of Analysis (COA) should be available for each batch, confirming peptide identity, purity, and analytical testing results to ensure research quality and traceability.

Is CJC-1295 (with DAC) FDA-approved?

No. CJC-1295 (with DAC) is not FDA-approved as a drug, supplement, or therapeutic product. It is sold exclusively as a research compound and must not be marketed or used for diagnostic, therapeutic, or consumption purposes.

⚠️ Research Use Only

This product is not for human consumption. It is sold strictly for research and educational purposes and is not intended to diagnose, treat, cure, or prevent any disease.

Any clinical data or research information referenced on this page is derived from peer-reviewed scientific literature and official publications. This information is provided for educational reference only and does not constitute medical advice or product claims.

By purchasing this product, you acknowledge that you are a qualified researcher and agree to use it in full compliance with all applicable laws and regulations.