Molecular Characteristics
Complete Specifications
Structural Composition
Ala-Gln-Leu-Glu-Arg-Ala-Leu-Glu-Ala-Leu-Gly-Gly-Ala-Gln-Ser-Leu
Physical Properties
ARA-290 is a 16-amino-acid synthetic peptide modeled after the helix-B surface region of erythropoietin. The truncated sequence preserves key structural elements while omitting the full erythropoietin protein framework. Its compact size supports efficient solubility and ease of handling in laboratory environments. Lyophilized formulation enhances stability during storage, while protection from light, moisture, and repeated freeze–thaw cycles helps maintain peptide integrity for research and analytical applications.
Research Applications
Cellular Protection and Tissue Injury Research
ARA-290 is utilized as a research compound in studies examining cellular protection mechanisms and tissue responses to injury. Laboratory investigations focus on its role in:
- Innate Repair Receptor Activation Models: Investigation of signaling pathways associated with tissue protection and repair responses
- Cell Survival Pathway Studies: Evaluation of intracellular mechanisms supporting cell viability under stress or injury conditions
- Anti-Inflammatory Signaling Research: Analysis of pathways involved in modulation of inflammatory mediators
- Tissue Stress Response Models: Research into adaptive cellular responses following mechanical, metabolic, or chemical stress
- Cytoprotective Signaling Mechanisms: Investigation of signaling cascades associated with reduced cellular damage
Experimental protocols commonly employ cell injury assays, stress-induction models, and molecular signaling analysis to characterize ARA-290–mediated protective responses.
Neurological and Peripheral Nerve Research
ARA-290 has been examined in research contexts involving neural tissue protection and peripheral nerve signaling. Key areas of investigation include:
- Peripheral Nerve Integrity Models: Evaluation of cellular responses supporting nerve structure and signaling stability
- Neuroinflammatory Pathway Studies: Investigation of inflammatory signaling within neural and glial cell populations
- Neuronal Stress Response Research: Analysis of adaptive mechanisms protecting neurons under injury or metabolic stress
- Signal Transmission Stability: Research into maintenance of neural signaling under adverse conditions
- Neurocellular Adaptation Models: Examination of long-term cellular adaptations following protective signaling activation
These studies utilize neuronal cell cultures, peripheral nerve models, and inflammatory signaling assays to assess neural protection outcomes.
Inflammation and Immune Modulation Research
ARA-290 has been explored in research models examining immune responses and inflammation regulation, including:
- Cytokine Signaling Regulation: Evaluation of inflammatory mediator expression and signaling balance
- Macrophage and Immune Cell Response Models: Investigation of immune cell activation and response modulation
- Inflammation Resolution Pathways: Research into mechanisms supporting return to immune homeostasis
- Tissue-Specific Immune Signaling: Examination of localized immune responses in affected tissues
Laboratory protocols assess immune signaling activity using cytokine profiling, cell-based assays, and inflammatory response models.
Cellular Signaling and Stress Adaptation Research
Additional research applications explore ARA-290’s influence on intracellular signaling systems involved in stress adaptation, including:
- JAK-STAT and Downstream Pathways: Investigation of signaling cascades associated with protective cellular responses
- Oxidative Stress Response Models: Analysis of antioxidant and protective signaling under cellular stress
- Apoptosis Regulation Studies: Research into modulation of programmed cell death pathways
- Cellular Homeostasis Maintenance: Examination of regulatory systems preserving tissue stability
Research in this domain focuses on understanding how ARA-290 supports cellular protection, modulates inflammatory signaling, and enhances stress adaptation under controlled experimental conditions.
Laboratory Handling and Storage Protocols
Lyophilized Powder Storage
- Store at –20°C to –80°C in the original, sealed vial
- Protect from light exposure and moisture
- A desiccated storage environment is recommended
- Stability data suggests extended stability when stored at −20 °C or below.
Reconstituted Solution Storage
- Short-term storage: Up to 7 days at 4°C
- Long-term storage: Store at –20°C in aliquots
- Use single-use aliquots to preserve peptide integrity
- Minimize freeze–thaw cycles; single-use aliquots are strongly recommended
Stability Characteristics
ARA-290 is a synthetic peptide research compound that demonstrates good stability when handled in accordance with standard peptide laboratory protocols. Maintaining proper cold storage, minimizing mechanical agitation during reconstitution, and limiting freeze–thaw exposure help preserve molecular integrity and solubility. When these conditions are met, ARA-290 supports consistent use in in vitro and analytical research applications.
Frequently Asked Questions
What is ARA-290?
ARA-290 is a synthetic EPO-derived peptide designed to selectively activate non-hematopoietic signaling pathways. It is studied in laboratory and preclinical environments to explore tissue protection and cellular repair mechanisms.
What is ARA-290 commonly researched for?
In experimental research settings, ARA-290 is investigated for:
-
Tissue-protective signaling mechanisms
-
Inflammatory response modulation
-
Neuroprotective and peripheral nerve research models
-
Cellular stress and repair pathway studies
All research use is preclinical and exploratory.
Is ARA-290 the same as erythropoietin (EPO)?
No. While ARA-290 is derived from a segment of erythropoietin, it does not stimulate red blood cell production in research models. It is specifically engineered to isolate tissue-protective signaling effects separate from erythropoiesis.
How is ARA-290 supplied?
ARA-290 is typically supplied as a lyophilized (freeze-dried) powder in sealed research vials. Lyophilization enhances stability during storage and shipment prior to laboratory preparation.
How should unreconstituted ARA-290 be stored?
Lyophilized ARA-290 should be stored:
-
Long-term: −20 °C to −80 °C
-
Short-term: 2–8 °C
Vials should remain sealed and protected from light and moisture.
How should reconstituted ARA-290 be handled and stored?
Once reconstituted:
-
Store at 2–8 °C for short-term laboratory use
-
For extended storage, aliquot and freeze at −20 °C or below
-
Minimize freeze–thaw cycles using single-use aliquots
-
Mix gently; avoid vigorous agitation
Does ARA-290 require a Certificate of Analysis (COA)?
Yes. A Certificate of Analysis (COA) should be available for each batch, confirming identity, purity, and analytical testing results to support research quality and traceability.
Is ARA-290 FDA-approved?
No. ARA-290 is not FDA-approved as a drug, supplement, or therapeutic product. It is sold exclusively as a research compound and must not be marketed or used for diagnostic, therapeutic, or consumption purposes.
This product is not for human consumption. It is sold strictly for research and educational purposes and is not intended to diagnose, treat, cure, or prevent any disease.
Any clinical data or research information referenced on this page is derived from peer-reviewed scientific literature and official publications. This information is provided for educational reference only and does not constitute medical advice or product claims.
By purchasing this product, you acknowledge that you are a qualified researcher and agree to use it in full compliance with all applicable laws and regulations.
