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Epitalon

Price range: $124.99 through $289.99

Epitalon (also known as Epithalon) is a synthetic tetrapeptide derived from epithalamin, studied for its role in cellular aging and telomerase activity regulation. In research settings, it’s explored for potential effects on telomere length, oxidative stress response, and circadian rhythm pathways. Intended for research use only, not for human or veterinary use.

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Description
Additional information

Molecular Characteristics

Complete Specifications

CAS Registry Number: 307297-39-8
PubChem CID: Not available
Peptide Classification: Synthetic tetrapeptide
Molecular Formula: C₁₄H₂₂N₄O₉
Molecular Weight: ~390.35 Da

Structural Composition

Amino Acid Sequence:
Ala-Glu-Asp-Gly (AEDG)
Length: 4 amino acids

Physical Properties

Appearance: White to off-white lyophilized powder
Solubility: Water, bacteriostatic water, buffered aqueous solutions (e.g., PBS)

Structural & Stability Notes

Epitalon is a synthetic tetrapeptide composed of four amino acids forming a short regulatory peptide sequence. Its compact structure supports strong aqueous solubility and efficient laboratory handling under controlled research conditions. Due to its minimal chain length, the peptide demonstrates predictable stability when stored in lyophilized form. Protection from moisture, light exposure, and repeated freeze–thaw cycles helps maintain structural integrity and analytical consistency during laboratory applications.

Research Applications

Telomere and Cellular Longevity Research

Epitalon is utilized as a research compound in studies examining telomere biology and cellular longevity mechanisms. Laboratory investigations focus on its role in:

Telomerase Activity Models: Investigation of telomerase expression and telomere length regulation in cellular systems
Cellular Senescence Studies: Evaluation of pathways associated with aging-related cellular changes
DNA Stability Research: Analysis of genomic integrity and chromosomal maintenance mechanisms
Cell Cycle Regulation: Examination of signaling pathways influencing cell replication timing and checkpoint control
Oxidative Stress Modulation: Investigation of redox balance and antioxidant signaling responses

Experimental protocols commonly employ cultured cell systems, telomere length assays, and molecular profiling techniques to characterize Epitalon-mediated cellular responses.

Circadian and Pineal Research

Epitalon has been examined in research contexts involving circadian rhythm regulation and pineal signaling pathways. Key areas of investigation include:

Melatonin Signaling Models: Evaluation of pathways associated with pineal hormone regulation
Circadian Rhythm Gene Expression: Investigation of clock gene regulation and rhythmic transcriptional patterns
Neuroendocrine Interaction Studies: Analysis of communication between pineal signaling and systemic endocrine systems
Sleep–Wake Cycle Models: Research into regulatory mechanisms influencing circadian synchronization
Chronobiology Studies: Examination of biological timing systems under experimental modulation

These studies utilize hormone profiling, gene expression analysis, and circadian monitoring systems to evaluate rhythmic biological processes.

Cellular Protection and Stress Response Research

Epitalon has also been explored in research models examining cellular resilience and stress adaptation, including:

Antioxidant Signaling Studies: Evaluation of cellular defense pathways against oxidative stress
DNA Repair Mechanism Research: Investigation of molecular pathways involved in genomic maintenance
Apoptosis Regulation Models: Analysis of programmed cell death signaling balance
Inflammatory Pathway Modulation: Examination of signaling systems influencing cellular stress responses

Laboratory protocols assess stress biomarkers, DNA integrity markers, and cellular survival pathways using biochemical and imaging-based techniques.

Gene Regulation and Epigenetic Research

Additional research applications explore Epitalon’s influence on intracellular signaling and gene regulatory systems, including:

Transcriptional Regulation Studies: Investigation of gene expression modulation associated with longevity-related pathways
Epigenetic Marker Analysis: Research into DNA methylation and chromatin remodeling mechanisms
Signal Transduction Cascades: Examination of intracellular pathways influencing long-term cellular stability
Homeostatic Regulation Systems: Analysis of regulatory networks maintaining cellular equilibrium

Research in this domain focuses on understanding how Epitalon influences telomere dynamics, circadian signaling, and gene regulatory pathways under controlled experimental conditions.

Laboratory Handling and Storage Protocols

Lyophilized Powder Storage

Store at –20°C to –80°C in the original, sealed vial
Protect from light exposure and moisture
A desiccated storage environment is recommended
Stability data suggests extended stability when stored at −20 °C or below.

Reconstitution Guidelines

Reconstitute using sterile water, bacteriostatic water (0.9% benzyl alcohol), or an appropriate laboratory buffer
Introduce solvent slowly along the vial wall to minimize foaming
Mix using gentle swirling; avoid vigorous agitation or shaking
Allow complete dissolution prior to use (typically 1–2 minutes)
Ensure the final solution is within a physiologically neutral pH range appropriate for laboratory use

Reconstituted Solution Storage

Short-term storage: Up to 7 days at 4°C
Long-term storage: Store at –20°C in aliquots
Use single-use aliquots to preserve peptide integrity
Minimize freeze–thaw cycles; single-use aliquots are strongly recommended

Stability Characteristics

Epitalon is a synthetic peptide research compound that demonstrates stable handling characteristics when managed according to standard peptide laboratory protocols. Proper cold storage of the lyophilized material, careful reconstitution, and minimized freeze–thaw exposure help preserve structural integrity and solubility. When handled appropriately, Epitalon supports consistent use in in vitro and analytical research applications.

Frequently Asked Questions

What is Epitalon?

Epitalon is a synthetic tetrapeptide designed to replicate a short peptide sequence associated with pineal gland research. It is studied in laboratory environments for its potential involvement in cellular regulation and telomere-related pathways.

What is Epitalon commonly researched for?

In experimental and preclinical models, Epitalon is studied for:

Telomerase activation mechanisms
Cellular aging and replication research
Pineal gland signaling pathways
Circadian rhythm and neuroendocrine studies

All research applications are exploratory and conducted in controlled laboratory settings.

Is Epitalon the same as Epithalon?

Yes. “Epitalon” and “Epithalon” are commonly used interchangeably to refer to the same synthetic tetrapeptide sequence in research contexts.

How is Epitalon supplied?

Epitalon is typically supplied as a lyophilized (freeze-dried) powder in sealed research vials to maintain stability during storage and transport.

How should unreconstituted DSIP be stored?

Lyophilized Epitalon should be stored:

Long-term: −20 °C to −80 °C
Short-term: 2–8 °C

Keep vials sealed and protected from light and moisture until use.

How should reconstituted Epitalon be handled and stored?

Once reconstituted:

Store at 2–8 °C for short-term laboratory use
For extended storage, aliquot and freeze at −20 °C or below
Minimize freeze–thaw cycles using single-use aliquots
Gently swirl to mix; avoid vigorous agitation

Does Epitalon require a Certificate of Analysis (COA)?

Yes. A Certificate of Analysis (COA) should be available for each batch, verifying peptide identity, purity, and analytical testing results to ensure research quality and traceability.

Is Epitalon FDA-approved?

No. Epitalon is not FDA-approved as a drug, supplement, or therapeutic product. It is sold exclusively as a research compound and must not be marketed or used for diagnostic, therapeutic, or consumption purposes.

⚠️ Research Use Only

This product is not for human consumption. It is sold strictly for research and educational purposes and is not intended to diagnose, treat, cure, or prevent any disease.

Any clinical data or research information referenced on this page is derived from peer-reviewed scientific literature and official publications. This information is provided for educational reference only and does not constitute medical advice or product claims.

By purchasing this product, you acknowledge that you are a qualified researcher and agree to use it in full compliance with all applicable laws and regulations.