For laboratory research use only. Not for human or veterinary use. This is educational reference information, not medical advice.
AEDG · Epithalon (Ala-Glu-Asp-Gly)
Epitalon
Cellular Research Compounds
| Scientific name | Epithalon (Ala-Glu-Asp-Gly) |
|---|---|
| Synonyms | Epithalone |
| Abbreviation | AEDG |
| CAS Number | 307297-39-8 |
| Molecular formula | C14H22N4O9 |
| Molecular weight | 390.35 g/mol (average) |
| Sequence (one-letter) | AEDG |
| Length | 4 residues |
| PubChem CID | 219042 |
2D / 3D structure
![2D chemical structure of Epitalon]()
Interactive sequence
Select a residue to see its amino acid.
Mechanisms under investigation
The following are areas of ongoing preclinical investigation. They describe hypotheses and observations reported in the literature, not established clinical effects.
Evidence tiers below reflect how much has been studied in each model type. Counts describe research volume — they do not indicate proven efficacy, safety, or clinical consensus.
Evidence base (transparent counts)
Cellular studies
2 publications
Animal studies
3 publications
Human observational reports
0 publications
Controlled human trials
0 publications
Review articles
1 publication
Selected literature
Filter by study model. Each record is classified for the evidence base above.
2025
Review summarizing the reported chemistry, biological activity and research literature on the pineal tetrapeptide epitalon.Review · PubMed (40141333)
2022
In vitro study assessing markers of post-ovulatory aging in cultured mouse oocytes exposed to epitalon.Cellular · mouse · PubMed (35413689)
2020
In vitro study examining effects of the AEDG peptide on gene expression and protein synthesis in neuronal differentiation models, with a proposed epigenetic mechanism.Cellular · PubMed (32019204)
2007
Animal study recording neocortical neuron activity in rats following intranasal administration of epitalon.Animal · rat · PubMed (17955380)
2006
Animal study evaluating spontaneous tumor development and lifespan parameters in female C3H/He mice given the synthetic pineal peptide epitalon.Animal · mouse · PubMed (16634527)
2002
Animal study reporting the incidence and development of spontaneous mammary tumors in HER-2/neu transgenic mice administered epitalon.Animal · mouse · PubMed (12209581)
Each record maps to a structured evidence row with study model, species, and support level.
Handling and reference
Molecular weight calculator
Average-mass estimate from a one-letter sequence.
Reconstitution calculator
Laboratory concentration only. Not dosing guidance.
What is Epitalon?
Epitalon is a research compound; the identity and structure data shown here are compiled from public chemical databases (primarily PubChem). For laboratory research use only.
What research models has it been studied in?
The literature indexed here is predominantly cellular (in vitro) and animal studies. See the evidence base and publication library above for the transparent counts by study model.
Is there controlled human clinical trial evidence?
Controlled human clinical trials are counted separately in the evidence base above. Cellular and animal findings do not establish human clinical effects.
How is it stored and handled in a laboratory?
Refer to the laboratory information section above.
Is this intended for human use?
No. All information and materials are for laboratory research use only — not for human or veterinary use, and not intended to diagnose, treat, cure, or prevent any disease.
Research material & documentation
This profile is an educational reference. Lot-level laboratory documentation for materials supplied by Peptide Titans is published openly.
Epitalon research material → · Lot-specific Certificates of Analysis → · How lots are tested →
Evidence records
- Review summarizing the reported chemistry, biological activity and research literature on the pineal tetrapeptide epitalon. (2025) — review — PubMed.
- In vitro study assessing markers of post-ovulatory aging in cultured mouse oocytes exposed to epitalon. (2022) — in vitro — PubMed.
- In vitro study examining effects of the AEDG peptide on gene expression and protein synthesis in neuronal differentiation models, with a proposed epigenetic mechanism. (2020) — in vitro — PubMed.
- Animal study recording neocortical neuron activity in rats following intranasal administration of epitalon. (2007) — in vivo — PubMed.
- Animal study evaluating spontaneous tumor development and lifespan parameters in female C3H/He mice given the synthetic pineal peptide epitalon. (2006) — in vivo — PubMed.
- Animal study reporting the incidence and development of spontaneous mammary tumors in HER-2/neu transgenic mice administered epitalon. (2002) — in vivo — PubMed.
Every record carries a study model, species, support level and review status in the evidence table.
Citation generator
Loading citation...
Explore the full research database
Browse peptide profiles, publications, and laboratory references — all research-only.
For laboratory research use only. Not for human or veterinary use. Educational reference information — not medical advice.