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BPC-157

Price range: $159.99 through $294.99

BPC-157 is a synthetic research peptide derived from a naturally occurring sequence found in human gastric juice. It is widely studied for its stability and unique biological properties, making it a common subject of laboratory and preclinical research focused on tissue response and cellular signaling pathways.

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Molecular Characteristics

Complete Specifications

CAS Registry Number: 137525-51-0
PubChem CID: 9941957
Peptide Classification: Synthetic pentadecapeptide
Molecular Formula: C₆₂H₉₈N₁₆O₂₂
Molecular Weight: 1,419.55 Da

Structural Composition

Amino Acid Sequence:
Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
Length: 15 amino acids

Physical Properties

Appearance: White to off-white lyophilized powder
Solubility: Water, bacteriostatic water, phosphate-buffered saline (PBS)

Structural & Stability Notes

The peptide’s 15-amino-acid configuration contributes to a distinct stability profile. Multiple proline residues within the sequence introduce conformational rigidity, which may enhance resistance to enzymatic degradation. The presence of both acidic residues (glutamic acid and aspartic acid) and a basic residue (lysine) results in a balanced charge distribution, supporting aqueous solubility and potentially influencing molecular interactions under research conditions.

Research Applications

Tissue Repair and Regeneration Research

BPC-157 is widely used as a research compound for studying fundamental mechanisms involved in tissue repair and regeneration. Laboratory investigations focus on its role in:

Wound Healing Models: Evaluation of repair processes across multiple tissue types and injury models
Cell Migration and Remodeling: Analysis of cellular movement, chemotaxis, and tissue reorganization during healing
Angiogenesis Studies: Examination of blood vessel formation, vascular endothelial growth factor (VEGF) signaling, and revascularization pathways
Collagen and Extracellular Matrix Formation: Research into collagen synthesis, deposition, and structural remodeling
Growth Factor Regulation: Investigation of growth factor expression and associated signaling pathways

Experimental protocols commonly utilize in vitro cell culture systems—including endothelial, fibroblast, and epithelial cells—as well as in vivo wound healing models to characterize molecular and cellular repair mechanisms.

Gastrointestinal Research

Due to its origin from gastric protective proteins, BPC-157 has been extensively studied in gastrointestinal research contexts. Key areas of investigation include:

Gastric Protection Mechanisms: Analysis of protective responses in experimental gastric injury models
Intestinal Barrier Integrity: Studies examining gut permeability, tight junction stability, and epithelial barrier maintenance
Mucosal Repair and Regeneration: Evaluation of epithelial healing processes and mucosal tissue recovery
Inflammatory Pathway Modulation: Research into the regulation of inflammatory mediators and protective signaling pathways
Ulcer Healing Models: Investigation of tissue repair mechanisms in experimental ulceration models

This body of research also explores the peptide’s stability within acidic gastric environments and its interactions with gastrointestinal repair pathways.

Musculoskeletal Research Applications

BPC-157 is frequently examined in studies involving musculoskeletal tissues, with research focusing on:

Tendon and Ligament Repair: Evaluation of connective tissue healing, collagen alignment, and structural strength
Muscle Tissue Regeneration: Investigation of muscle fiber repair processes and recovery mechanisms
Bone Healing Studies: Research on bone formation, mineralization, and regenerative activity
Joint and Cartilage Protection: Examination of chondrocyte function, cartilage integrity, and joint tissue maintenance

Experimental models include tendon injury, muscle damage, and bone repair systems, with outcomes assessed through histological analysis, biomechanical testing, and molecular pathway evaluation.

Cardiovascular and Vascular Research

Research applications also extend to vascular and cardiovascular systems, including studies on:

Endothelial Cell Function: Analysis of nitric oxide signaling, endothelial responsiveness, and vascular regulation
Microcirculation and Blood Flow: Investigation of tissue perfusion, vascular remodeling, and circulation dynamics
Vascular Repair Mechanisms: Research into blood vessel healing, neovascularization, and vascular protection
Cardioprotective Pathways: Examination of cardiac tissue protection mechanisms in experimental settings

Laboratory protocols assess BPC-157’s influence on endothelial signaling pathways, vascular growth factors, and protective responses to vascular injury.

Neurological Research

Emerging research areas explore BPC-157’s potential role in neurological models, including:

Neuroprotection Studies: Investigation of protective mechanisms in neuronal injury models
Brain Injury Research: Analysis of neural recovery processes and protective signaling pathways
Spinal Cord Injury Models: Studies examining tissue repair and functional recovery mechanisms
Blood–Brain Barrier Research: Evaluation of BBB permeability and interactions with central nervous system tissues

Research in this domain focuses on understanding BPC-157’s interactions with neural tissues and its potential influence on nervous system repair pathways under experimental conditions.

Laboratory Handling and Storage Protocols

Lyophilized Powder Storage

Store at –20°C to –80°C in the original, sealed vial
Protect from light exposure and moisture
A desiccated storage environment is recommended
Stability data suggests extended stability when stored at −20 °C or below.

Reconstitution Guidelines

Reconstitute using sterile water, bacteriostatic water (0.9% benzyl alcohol), or an appropriate laboratory buffer
Introduce solvent slowly along the vial wall to minimize foaming
Mix using gentle swirling; avoid vigorous agitation or shaking
Allow complete dissolution prior to use (typically 1–2 minutes)
Target a final solution pH of 7.0–8.0 for optimal stability

Reconstituted Solution Storage

Short-term storage: Up to 7 days at 4°C
Long-term storage: Store at –20°C in aliquots
Use single-use aliquots to preserve peptide integrity
Minimize freeze–thaw cycles; single-use aliquots are strongly recommended

Stability Characteristics

BPC-157 exhibits a notably robust stability profile relative to many research peptides. Experimental data indicates resistance to degradation across a broad pH range, including acidic environments (pH ~1.5), as well as maintained structural integrity under varied storage conditions. This enhanced stability supports greater flexibility in experimental design and handling protocols.

Frequently Asked Questions

What is BPC-157?

BPC-157 is a synthetic peptide originally derived from a sequence found in gastric proteins. It is commonly used in laboratory and preclinical research to study cellular signaling, tissue response mechanisms, and peptide stability.

What is BPC-157 used for?

In research environments, BPC-157 is studied for its interaction with cellular repair pathways, angiogenesis signaling, and inflammatory response mechanisms. These studies are conducted in controlled laboratory models and are intended for educational and scientific investigation only.

Is BPC-157 approved for human use?

No. BPC-157 is not approved by the FDA or any regulatory authority for human consumption or medical treatment. Products sold on this site are strictly for research and laboratory use only.

How is BPC-157 supplied for research purposes?

BPC-157 is typically supplied as a lyophilized (freeze-dried) powder to ensure stability during storage and transport. Researchers reconstitute it according to their experimental protocols using appropriate laboratory techniques.

How should BPC-157 be stored?

Unreconstituted BPC-157 should generally be stored in a cool, dry environment, preferably refrigerated or frozen as specified in the product documentation. Once reconstituted, it should be kept at 2–8°C and used within approximately 30 days.

What quality standards are applied to BPC-157 products?

BPC-157 products are manufactured and handled using research-grade quality standards, including identity verification and purity testing such as HPLC or mass spectrometry, depending on the batch. Certificates of Analysis (COAs) are typically made available for transparency and laboratory reference.

⚠️ Research Use Only

This product is not for human consumption. It is sold strictly for research and educational purposes and is not intended to diagnose, treat, cure, or prevent any disease.

Any clinical data or research information referenced on this page is derived from peer-reviewed scientific literature and official publications. This information is provided for educational reference only and does not constitute medical advice or product claims.

By purchasing this product, you acknowledge that you are a qualified researcher and agree to use it in full compliance with all applicable laws and regulations.