Molecular Characteristics
Complete Specifications
Structural Composition
Aib-His-D-2-Nal-D-Phe-Lys-NH₂
Physical Properties
Ipamorelin is a synthetic pentapeptide containing non-natural amino acid residues such as Aib (α-aminoisobutyric acid) and D-configured aromatic residues, which enhance resistance to enzymatic degradation compared to peptides composed solely of L-amino acids. These structural modifications contribute to improved stability under controlled research conditions. Its short chain length supports efficient aqueous solubility and practical laboratory handling. Lyophilized storage and protection from moisture, light exposure, and repeated freeze–thaw cycles help preserve peptide integrity and maintain analytical consistency during research applications.
Analysis & Documentation
Identity
Each production lot is checked against the reference structure recorded for this compound:
- Classification — Synthetic pentapeptide (growth hormone–releasing peptide)
- Molecular formula — C₃₈H₄₉N₉O₅
- Expected mass — ~711.85 Da
- CAS registry — 170851-70-4
- Chain length — 5 amino acids
- PubChem CID — Not available
Analytical Methods
Testing is carried out per lot by an independent laboratory. The methods measure what the material is and how much of it is the target compound:
- RP-HPLC — reverse-phase separation of the target from process-related impurities; purity is reported as area percent of the main peak
- Mass spectrometry — observed mass compared against the expected molecular mass above
- Retention time — compared against a reference standard run under the same conditions
- Chromatogram — reproduced on the certificate so the peak and any shoulders can be inspected directly
Material & Documentation
What arrives, and how to tie it back to its paperwork:
- Appearance as supplied — White to off-white lyophilized powder
- Solubility — Water, phosphate-buffered saline (PBS)
- Lot number — printed on the container label and used to look up the certificate
- Certificate — indexed by lot at Certificates of Analysis
Laboratory Handling and Storage Protocols
Lyophilized Powder Storage
- Store at –20°C to –80°C in the original, sealed vial
- Protect from light exposure and moisture
- A desiccated storage environment is recommended
- Stability data suggests extended stability when stored at −20 °C or below.
Reconstituted Solution Storage
- Short-term storage: Up to 7 days at 4°C
- Long-term storage: Store at –20°C in aliquots
- Use single-use aliquots to preserve peptide integrity
- Minimize freeze–thaw cycles; single-use aliquots are strongly recommended
Stability Characteristics
Ipamorelin is a synthetic peptide research compound that demonstrates stable handling characteristics when managed according to standard peptide laboratory protocols. Proper cold storage of the lyophilized material, careful reconstitution, and minimized freeze–thaw exposure help preserve structural integrity and solubility. When handled appropriately, Ipamorelin supports consistent use in in vitro and analytical research applications.
Frequently Asked Questions
What is Ipamorelin?
Ipamorelin is a synthetic five–amino acid peptide designed to activate the GHS-R1a receptor in experimental models. It is commonly used in laboratory research focused on growth hormone signaling mechanisms.
How does Ipamorelin differ from other GHRPs?
Ipamorelin is structurally distinct from peptides such as GHRP-2, GHRP-6, and Hexarelin. In research models, it is often noted for its receptor selectivity, which may influence downstream signaling characteristics compared to other growth hormone secretagogues.
Is Ipamorelin the same as GHRH analogs like CJC-1295?
No. Ipamorelin primarily activates the ghrelin receptor (GHS-R1a), whereas GHRH analogs such as CJC-1295 act through the GHRH receptor. While both are studied in growth hormone–related research, their mechanisms differ.
How is Ipamorelin supplied?
Ipamorelin is typically supplied as a lyophilized (freeze-dried) powder in sealed research vials to maintain stability during storage and shipment.
How should unreconstituted Ipamorelin be stored?
Lyophilized Ipamorelin should be stored:
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Long-term: −20 °C to −80 °C
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Short-term: 2–8 °C
Keep vials sealed and protected from light and moisture until use.
How should reconstituted Ipamorelin be handled and stored?
Once reconstituted:
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Store at 2–8 °C for short-term laboratory use
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For extended storage, aliquot and freeze at −20 °C or below
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Minimize freeze–thaw cycles using single-use aliquots
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Gently swirl to mix; avoid vigorous agitation
Does Ipamorelin require a Certificate of Analysis (COA)?
Yes. A Certificate of Analysis (COA) should be available for each batch of Ipamorelin, verifying identity, purity, and analytical testing results to ensure research quality and traceability.
Is Ipamorelin FDA-approved?
No. Ipamorelin is not FDA-approved as a drug, supplement, or therapeutic product. It is sold exclusively as a research compound and must not be marketed or used for diagnostic, therapeutic, or consumption purposes.
This product is not for human consumption. It is sold strictly for research and educational purposes and is not intended to diagnose, treat, cure, or prevent any disease.
Any clinical data or research information referenced on this page is derived from peer-reviewed scientific literature and official publications. This information is provided for educational reference only and does not constitute medical advice or product claims.
By purchasing this product, you acknowledge that you are a qualified researcher and agree to use it in full compliance with all applicable laws and regulations.
