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GHRP-2

Name: GHRP-2
Brand: Peptide Titans
SKU: 894
Availability: InStock

Price range: $149.99 through $279.99

GHRP-2 (Growth Hormone–Releasing Peptide-2) is a synthetic hexapeptide studied for its ability to stimulate growth hormone secretion via activation of the ghrelin (GHS-R1a) receptor. In research settings, it’s explored for effects on IGF-1 signaling, appetite-related pathways, and metabolic regulation mechanisms. Intended for research use only, not for human or veterinary use.

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Molecular Characteristics

Complete Specifications

CAS Registry Number: 158861-67-7
PubChem CID: 5486979
Peptide Classification: Synthetic hexapeptide growth hormone–releasing peptide (GHRP)
Molecular Formula: C₄₅H₅₅N₉O₆
Molecular Weight: ~817.0 Da

Structural Composition

Amino Acid Sequence:
D-Ala-D-β-Nal-Ala-Trp-D-Phe-Lys-NH₂
Length: 6 amino acids (modified hexapeptide)

Physical Properties

Appearance: White to off-white lyophilized powder
Solubility: Water, bacteriostatic water, buffered aqueous solutions (e.g., PBS)

Structural & Stability Notes

GHRP-2 is a synthetic hexapeptide containing non-natural amino acid residues, including D-amino acids, which contribute to increased resistance to enzymatic degradation under research conditions. Its compact structure supports strong aqueous solubility and efficient laboratory handling. As with other short peptides, lyophilized storage under cold, dry conditions is recommended. Protection from moisture, light exposure, and repeated freeze–thaw cycles helps preserve structural integrity and maintain analytical consistency during laboratory applications.

Research Applications

Ghrelin Receptor and Growth Hormone Signaling Research

GHRP-2 is utilized as a synthetic growth hormone secretagogue in research studies examining ghrelin receptor (GHS-R1a) activation and growth hormone–associated intracellular signaling pathways. Laboratory investigations focus on its role in:

GHS-R1a Receptor Activation Models: Investigation of receptor binding dynamics and downstream signaling cascades
Calcium-Dependent Signaling Studies: Evaluation of intracellular Ca²⁺ flux and associated hormone release mechanisms
Pituitary Somatotroph Research: Analysis of intracellular pathways regulating growth hormone secretion dynamics
IP3/DAG Pathway Models: Examination of second messenger systems activated via Gq-coupled receptor signaling
Peptide Stability Studies: Investigation of structural persistence and receptor affinity in laboratory systems

Experimental protocols commonly employ receptor-binding assays, pituitary cell cultures, and intracellular signaling analyses to characterize GHRP-2–mediated endocrine responses.

Growth Hormone Axis and Endocrine Regulation Research

GHRP-2 has been examined in research contexts involving growth hormone regulatory networks and hypothalamic–pituitary signaling systems. Key areas of investigation include:

GH Pulse Secretion Models: Evaluation of temporal hormone release patterns under controlled stimulation
Hypothalamic Interaction Studies: Investigation of signaling pathways involving GHRH and somatostatin regulation
IGF-1 Axis Research: Analysis of downstream signaling cascades associated with growth hormone–mediated pathways
Endocrine Feedback Models: Research into coordinated regulatory loops within growth hormone systems
Receptor Sensitivity Studies: Examination of adaptive responsiveness within ghrelin receptor systems

These studies utilize hormone quantification assays, transcription factor profiling, and intracellular kinase activation analyses to evaluate endocrine signaling outcomes.

Metabolic and Appetite Signaling Research

GHRP-2 has also been explored in research models examining metabolic regulation and appetite-associated signaling pathways, including:

Hypothalamic Appetite Models: Evaluation of intracellular cascades influencing feeding-related signaling pathways
Glucose Regulation Studies: Investigation of signaling mechanisms associated with metabolic balance
Adipocyte Interaction Research: Analysis of intracellular pathways influencing lipid-associated signaling
Energy Homeostasis Models: Examination of coordinated signaling systems governing substrate utilization

Laboratory protocols assess metabolic biomarkers, hormone levels, and intracellular signaling pathways using biochemical and molecular techniques.

Cellular Signaling and Ghrelin Network Research

Additional research applications explore GHRP-2’s influence on intracellular regulatory systems involved in ghrelin receptor signaling and endocrine coordination, including:

MAPK and ERK Pathway Studies: Investigation of downstream cascades associated with receptor activation
Gene Expression Profiling: Analysis of transcriptional responses linked to endocrine and metabolic signaling
Receptor Modulation Research: Examination of adaptive signaling modulation within GHS-R1a systems
Integrated Hormonal Network Models: Analysis of coordinated signaling systems maintaining endocrine equilibrium

Research in this domain focuses on understanding how GHRP-2 influences ghrelin receptor–mediated signaling pathways, growth hormone regulatory systems, and metabolic-associated intracellular responses under controlled experimental conditions.

Laboratory Handling and Storage Protocols

Lyophilized Powder Storage

Store at –20°C to –80°C in the original, sealed vial
Protect from light exposure and moisture
A desiccated storage environment is recommended
Stability data suggests extended stability when stored at −20 °C or below.

Reconstitution Guidelines

Reconstitute using sterile water, bacteriostatic water (0.9% benzyl alcohol), or an appropriate laboratory buffer
Introduce solvent slowly along the vial wall to minimize foaming
Mix using gentle swirling; avoid vigorous agitation or shaking
Allow complete dissolution prior to use (typically 1–2 minutes)
Ensure the final solution is within a physiologically neutral pH range appropriate for laboratory use

Reconstituted Solution Storage

Short-term storage: Up to 7 days at 4°C
Long-term storage: Store at –20°C in aliquots
Use single-use aliquots to preserve peptide integrity
Minimize freeze–thaw cycles; single-use aliquots are strongly recommended

Stability Characteristics

GHRP-6 is a synthetic peptide research compound that demonstrates stable handling characteristics when managed according to standard peptide laboratory protocols. Proper cold storage of the lyophilized material, careful reconstitution, and minimized freeze–thaw exposure help preserve structural integrity and solubility. When handled appropriately, GHRP-6 supports consistent use in in vitro and analytical research applications.

Frequently Asked Questions

What is GHRP-2?

GHRP-2 is a synthetic six–amino acid peptide designed to activate the GHS-R1a receptor in experimental models. It is commonly used in research involving growth hormone signaling mechanisms.

What is GHRP-2 commonly researched for?

In laboratory and preclinical models, GHRP-2 is studied for:

Growth hormone secretagogue receptor (GHS-R1a) activation
Growth hormone release pathway research
Ghrelin receptor signaling investigations
Hypothalamic–pituitary axis studies
Endocrine and metabolic pathway models

All applications are exploratory and conducted in controlled research environments.

How does GHRP-2 differ from other GHRPs?

GHRP-2 is one of several growth hormone–releasing peptides. Compared to others in the class (such as GHRP-6 or Ipamorelin), it has a distinct amino acid sequence and may exhibit different receptor interaction characteristics in research models.

Is GHRP-2 the same as ghrelin?

No. GHRP-2 is a synthetic analog that interacts with the ghrelin receptor (GHS-R1a), whereas ghrelin is a naturally occurring endogenous hormone.

Is GHRP-2 a peptide?

Yes. GHRP-2 is a synthetic peptide composed of six amino acids (hexapeptide).

How is GHRP-2 supplied?

GHRP-2 is typically supplied as a lyophilized (freeze-dried) powder in sealed research vials to preserve stability during storage and shipment.

How should unreconstituted GHRP-2 be stored?

Lyophilized GHRP-2 should be stored:

Long-term: −20 °C to −80 °C
Short-term: 2–8 °C

Keep vials sealed and protected from light and moisture until use.

How should reconstituted GHRP-2 be handled and stored?

Once reconstituted:

Store at 2–8 °C for short-term laboratory use
For extended storage, aliquot and freeze at −20 °C or below
Minimize freeze–thaw cycles using single-use aliquots
Gently swirl to mix; avoid vigorous agitation

Does GHRP-2 require a Certificate of Analysis (COA)?

Yes. A Certificate of Analysis (COA) should be available for each batch, verifying peptide identity, purity, and analytical testing results to ensure research quality and traceability.

Is GHRP-2 FDA-approved?

No. GHRP-2 is not FDA-approved as a drug, supplement, or therapeutic product. It is sold exclusively as a research compound and must not be marketed or used for diagnostic, therapeutic, or consumption purposes.

⚠️ Research Use Only

This product is not for human consumption. It is sold strictly for research and educational purposes and is not intended to diagnose, treat, cure, or prevent any disease.

Any clinical data or research information referenced on this page is derived from peer-reviewed scientific literature and official publications. This information is provided for educational reference only and does not constitute medical advice or product claims.

By purchasing this product, you acknowledge that you are a qualified researcher and agree to use it in full compliance with all applicable laws and regulations.