Molecular Characteristics
Complete Specifications
Structural Composition
Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Ser-Gly-Phe-Gly
Physical Properties
AOD9604 is a synthetic 14-amino-acid peptide derived from the C-terminal fragment (176–191) of human growth hormone. The truncated sequence is engineered to retain structural characteristics relevant for laboratory investigation while excluding the full-length hormone framework. Its short chain length supports efficient solubility and handling under controlled research conditions. Lyophilized presentation enhances stability, and protection from light, moisture, and repeated freeze–thaw cycles helps preserve peptide integrity during storage and analytical use.
Research Applications
Adipose Metabolism and Lipid Regulation Research
AOD-9604 is utilized as a research compound in studies examining adipose metabolism and lipid regulatory mechanisms. Laboratory investigations focus on its role in:
- Lipolysis Signaling Models: Investigation of pathways involved in triglyceride breakdown and fatty acid release
- Fat Accumulation Inhibition Studies: Evaluation of mechanisms limiting lipid storage within adipocytes
- Adipocyte Metabolic Activity: Analysis of cellular energy utilization and lipid handling processes
- Hormone-Sensitive Lipase Pathways: Research into enzymatic systems regulating fat mobilization
- Selective Metabolic Signaling: Investigation of targeted signaling activity related to lipid metabolism
Experimental protocols commonly employ adipocyte cell cultures, lipid flux assays, and metabolic profiling techniques to characterize AOD-9604–mediated metabolic effects.
Weight Regulation and Energy Balance Research
AOD-9604 has been examined in research models related to body mass regulation and systemic energy balance. Key areas of investigation include:
- Energy Expenditure Models: Evaluation of basal metabolic activity and substrate utilization
- Adipose Tissue Reduction Pathways: Investigation of biological mechanisms influencing fat mass changes
- Metabolic Efficiency Studies: Analysis of energy conversion and metabolic throughput
- Glucose and Lipid Interaction Models: Research into cross-talk between carbohydrate and fat metabolism
- Long-Term Metabolic Adaptation: Examination of adaptive responses to sustained metabolic signaling changes
This body of research utilizes metabolic chamber studies, adipose-specific assays, and longitudinal metabolic models to assess systemic responses.
Growth Hormone Fragment Research
As a specific fragment derived from growth hormone, AOD-9604 has been explored in research focused on selective signaling properties, including:
- Receptor-Independent Activity Models: Evaluation of signaling pathways distinct from classical growth hormone receptors
- Selective Metabolic Signaling: Investigation of targeted metabolic effects without growth-related signaling
- Peptide Stability and Activity Studies: Research into structural stability and functional persistence in experimental systems
- Signal Specificity Analysis: Examination of pathway selectivity related to metabolic endpoints
Laboratory protocols assess receptor interaction profiles, signaling specificity, and metabolic outcomes using biochemical and cellular assays.
Cellular Signaling and Metabolic Stress Research
Additional research applications explore AOD-9604’s influence on cellular signaling under metabolic demand, including:
- cAMP and Lipid Signaling Pathways: Investigation of intracellular signaling involved in fat metabolism
- Cellular Energy Stress Responses: Analysis of adaptive mechanisms during altered energy availability
- Inflammatory and Stress Marker Studies: Research into secondary signaling responses associated with metabolic modulation
- Cellular Homeostasis Maintenance: Examination of regulatory systems preserving metabolic equilibrium
Research in this domain focuses on understanding how AOD-9604 influences lipid metabolism, energy balance signaling, and cellular adaptation under controlled experimental conditions.
Laboratory Handling and Storage Protocols
Lyophilized Powder Storage
- Store at –20°C to –80°C in the original, sealed vial
- Protect from light exposure and moisture
- A desiccated storage environment is recommended
- Stability data suggests extended stability when stored at −20 °C or below.
Reconstituted Solution Storage
- Short-term storage: Up to 7 days at 4°C
- Long-term storage: Store at –20°C in aliquots
- Use single-use aliquots to preserve peptide integrity
- Minimize freeze–thaw cycles; single-use aliquots are strongly recommended
Stability Characteristics
AOD-9604 is a synthetic peptide fragment that demonstrates good stability when handled according to standard peptide laboratory protocols. Proper cold storage of the lyophilized material, careful reconstitution, and minimized freeze–thaw exposure help maintain molecular integrity and solubility. When these practices are followed, AOD-9604 supports consistent use in in vitro and analytical research applications.
Frequently Asked Questions
What is AOD-9604?
AOD-9604 is a synthetic research peptide consisting of amino acids 177–191 of human growth hormone. It is designed to isolate and study specific metabolic signaling effects associated with this region of the hGH molecule in laboratory and preclinical models.
What is AOD-9604 commonly researched for?
In experimental research environments, AOD-9604 is studied for:
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Lipid metabolism and fat-related signaling pathways
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Regulation of lipolysis and lipogenesis models
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Metabolic and adipocyte signaling research
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GH-independent pathway investigation
All studies are preclinical and exploratory in nature.
Is AOD-9604 the same as HGH or HGH-derived peptides?
No. Although AOD-9604 is derived from a fragment of human growth hormone, it does not function as HGH and does not activate the growth hormone receptor in research models. It is studied specifically for GH-independent signaling mechanisms.
How is AOD-9604 supplied?
AOD-9604 is typically supplied as a lyophilized (freeze-dried) powder in sealed research vials. This format supports stability during storage and transport prior to laboratory preparation.
How should unreconstituted AOD-9604 be stored?
Lyophilized AOD-9604 should be stored:
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Long-term: −20 °C to −80 °C
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Short-term: 2–8 °C
Vials should remain sealed and protected from light and moisture.
How should reconstituted AOD-9604 be handled and stored?
Once reconstituted:
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Store at 2–8 °C for short-term laboratory use
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For longer-term storage, aliquot and freeze at −20 °C or below
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Minimize freeze–thaw cycles using single-use aliquots
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Gently swirl to mix; avoid vigorous agitation
Does AOD-9604 require a Certificate of Analysis (COA)?
Yes. A Certificate of Analysis (COA) should be available for each batch, confirming peptide identity, purity, and analytical testing results to support research consistency and quality assurance.
Is AOD-9604 FDA-approved?
No. AOD-9604 is not FDA-approved as a drug, supplement, or therapeutic product. It is sold exclusively as a research compound and must not be marketed or used for diagnostic, therapeutic, or consumption purposes.
This product is not for human consumption. It is sold strictly for research and educational purposes and is not intended to diagnose, treat, cure, or prevent any disease.
Any clinical data or research information referenced on this page is derived from peer-reviewed scientific literature and official publications. This information is provided for educational reference only and does not constitute medical advice or product claims.
By purchasing this product, you acknowledge that you are a qualified researcher and agree to use it in full compliance with all applicable laws and regulations.
