Molecular Characteristics
Complete Specifications
Structural Composition
His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH₂
Physical Properties
VIP (Vasoactive Intestinal Peptide) is a 28-amino-acid neuropeptide hormone characterized by a C-terminal amidation that contributes to structural stability. As a mid-length linear peptide, it is susceptible to enzymatic degradation in biological systems. Lyophilized storage under cold, dry conditions is recommended to preserve structural integrity. Protection from moisture, light exposure, and repeated freeze–thaw cycles helps maintain analytical consistency during laboratory research applications.
Analysis & Documentation
Identity
Each production lot is checked against the reference structure recorded for this compound:
- Classification — Synthetic 28-amino-acid neuropeptide hormone
- Molecular formula — C₁₄₇H₂₃₄N₄₄O₄₃S
- Expected mass — ~3,326.9 Da
- CAS registry — 37221-79-7
- Chain length — 28 amino acids (C-terminal amidated)
- PubChem CID — 16129704
Analytical Methods
Testing is carried out per lot by an independent laboratory. The methods measure what the material is and how much of it is the target compound:
- RP-HPLC — reverse-phase separation of the target from process-related impurities; purity is reported as area percent of the main peak
- Mass spectrometry — observed mass compared against the expected molecular mass above
- Retention time — compared against a reference standard run under the same conditions
- Chromatogram — reproduced on the certificate so the peak and any shoulders can be inspected directly
Material & Documentation
What arrives, and how to tie it back to its paperwork:
- Appearance as supplied — White to off-white lyophilized powder
- Solubility — Water, buffered aqueous solutions (e.g., PBS)
- Lot number — printed on the container label and used to look up the certificate
- Certificate — indexed by lot at Certificates of Analysis
Laboratory Handling and Storage Protocols
Lyophilized Powder Storage
- Store at –20°C to –80°C in the original, sealed vial
- Protect from light exposure and moisture
- A desiccated storage environment is recommended
- Stability data suggests extended stability when stored at −20 °C or below.
Reconstituted Solution Storage
- Short-term storage: Up to 7 days at 4°C
- Long-term storage: Store at –20°C in aliquots
- Use single-use aliquots to preserve peptide integrity
- Minimize freeze–thaw cycles; single-use aliquots are strongly recommended
Stability Characteristics
VIP (Vasoactive Intestinal Peptide) is a synthetic peptide research compound that demonstrates stable handling characteristics when managed under standard peptide laboratory protocols. Proper cold storage, protection from light, appropriate solvent selection, and minimized mechanical agitation help preserve structural integrity and solubility. When handled appropriately, VIP supports consistent use in in vitro and analytical research applications.
Frequently Asked Questions
What is VIP?
VIP (Vasoactive Intestinal Peptide) is a naturally occurring neuropeptide involved in multiple physiological signaling systems. Synthetic research-grade VIP replicates this endogenous peptide for experimental investigation.
Is VIP naturally occurring?
Yes. VIP is produced naturally in neurons and certain peripheral tissues. Research-grade VIP is synthesized to replicate the endogenous 28–amino acid sequence.
How does VIP differ from PACAP?
VIP and PACAP (Pituitary Adenylate Cyclase–Activating Polypeptide) are structurally related neuropeptides. While they share some receptor interactions, they differ in receptor affinity and signaling profiles in experimental models.
How is VIP supplied?
VIP is typically supplied as a lyophilized (freeze-dried) powder in sealed research vials to preserve stability during storage and shipment.
How should unreconstituted VIP be stored?
Lyophilized VIP should be stored:
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Long-term: −20 °C to −80 °C
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Short-term: 2–8 °C
Keep vials sealed and protected from light and moisture until use.
How should reconstituted VIP be handled and stored?
Once reconstituted:
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Store at 2–8 °C for short-term laboratory use
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For extended storage, aliquot and freeze at −20 °C or below
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Minimize freeze–thaw cycles using single-use aliquots
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Gently swirl to mix; avoid vigorous agitation
Does VIP require a Certificate of Analysis (COA)?
Yes. A Certificate of Analysis (COA) should be available for each batch of VIP, verifying identity, purity, and analytical testing results to ensure research quality and traceability.
Is VIP FDA-approved?
Research-grade VIP is not FDA-approved as a drug, supplement, or therapeutic product. It is sold exclusively as a research compound and must not be marketed or used for diagnostic, therapeutic, or consumption purposes.
This product is not for human consumption. It is sold strictly for research and educational purposes and is not intended to diagnose, treat, cure, or prevent any disease.
Any clinical data or research information referenced on this page is derived from peer-reviewed scientific literature and official publications. This information is provided for educational reference only and does not constitute medical advice or product claims.
By purchasing this product, you acknowledge that you are a qualified researcher and agree to use it in full compliance with all applicable laws and regulations.
