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KLOW

Original price was: $689.99.Current price is: $574.99.

KLOW is a multi-peptide research blend containing GHK-Cu, BPC-157, TB-500, and KPV, formulated for the study of tissue repair, inflammatory signaling, and cellular regeneration pathways. In research settings, it’s explored for potential interactions with collagen synthesis, angiogenesis, epithelial integrity, and immune-modulating mechanisms. Blend composition and ratios may vary by formulation. Intended for research use only, not for human or veterinary use.

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Molecular Characteristics

Complete Specifications

CAS Registry Number: Not assigned (multi-peptide blend)
PubChem CID: Not available
Peptide Classification: Multi-peptide blend (GHK-Cu + BPC-157 + TB-500 + KPV)
Molecular Formula: Variable (multi-component peptide blend)
Molecular Weight: Variable (multi-component peptide blend)

Structural Composition

Blend Composition:
GHK-Cu (copper tripeptide complex) + BPC-157 (15-amino-acid synthetic peptide) + TB-500 (Thymosin Beta-4 analog peptide) + KPV (Lys-Pro-Val tripeptide)
Length: Variable (3 aa metal complex + 15 aa peptide + 43 aa peptide + 3 aa peptide)

Physical Properties

Appearance: Blue-tinted to off-white lyophilized powder (blend-dependent)
Solubility: Water, bacteriostatic water, phosphate-buffered saline (PBS)

Structural & Stability Notes

KLOW is a composite peptide blend combining GHK-Cu (a copper (II) coordination complex of Gly-His-Lys), BPC-157 (a 15-amino-acid synthetic peptide), TB-500 (a 43-amino-acid Thymosin Beta-4 analog), and KPV (a short Lys-Pro-Val tripeptide). Because the formulation contains multiple distinct peptide structures and a metal-bound peptide complex, overall molecular formula and molecular weight are inherently variable and depend on blend ratios and hydration state. Lyophilized presentation supports storage stability, while protection from moisture, light, and repeated freeze–thaw cycles helps maintain structural integrity and analytical consistency for laboratory and research applications.

Research Applications

Dermal and Extracellular Matrix Research

KLOW is utilized as a multi-peptide research blend combining GHK-Cu, BPC-157, TB-500, and KPV in studies examining dermal biology, extracellular matrix regulation, and tissue remodeling pathways. Laboratory investigations focus on its role in:

Collagen and Elastin Regulation Models: Investigation of structural protein synthesis and extracellular matrix organization
Fibroblast Proliferation Studies: Evaluation of dermal cell signaling and matrix production dynamics
Angiogenic Signaling Research: Analysis of vascular growth factor pathways and microvascular support mechanisms
Cell Migration and Remodeling Models: Examination of cytoskeletal reorganization and tissue restructuring processes
Matrix Metalloproteinase Regulation: Investigation of enzymatic pathways governing extracellular matrix turnover

Experimental protocols commonly employ dermal fibroblast cultures, extracellular matrix assays, and tissue remodeling models to characterize KLOW blend–mediated structural responses.

Inflammatory and Barrier Integrity Research

KLOW has been examined in research contexts involving inflammatory modulation and epithelial barrier stability. Key areas of investigation include:

Cytokine Expression Profiling: Evaluation of inflammatory mediator signaling in dermal and epithelial systems
NF-κB Pathway Studies: Investigation of transcription factor signaling associated with inflammatory regulation
Epithelial Barrier Models: Analysis of tight junction stability and permeability control mechanisms
Inflammation Resolution Signaling: Research into pathways balancing tissue repair and immune activation
Oxidative Stress Modulation: Examination of redox balance and antioxidant-associated mechanisms

These studies utilize cytokine assays, oxidative biomarker profiling, and epithelial integrity models to evaluate inflammatory and structural outcomes.

Musculoskeletal and Connective Tissue Research

KLOW has also been explored in research models examining connective tissue signaling and regenerative pathway dynamics, including:

Tendon and Ligament Cell Studies: Evaluation of collagen alignment and connective tissue remodeling signaling
Actin Cytoskeleton Regulation Models: Investigation of cellular motility and structural organization pathways
Angiogenesis in Soft Tissue Research: Analysis of vascular signaling within connective tissues
Extracellular Matrix Repair Models: Examination of coordinated structural repair mechanisms

Laboratory protocols assess histological structure, cellular migration patterns, and molecular signaling pathways using biochemical and imaging-based techniques.

Cellular Signaling and Regenerative Pathway Research

Additional research applications explore KLOW’s combined influence on intracellular regulatory systems involved in tissue regeneration and homeostatic balance, including:

MAPK and PI3K-AKT Pathway Studies: Investigation of growth-related intracellular signaling cascades
Gene Expression Profiling: Analysis of transcriptional responses associated with matrix regulation and cellular repair
Copper-Dependent Enzymatic Activity Research: Examination of enzymatic systems influencing extracellular stability
Homeostatic Regulatory Mechanisms: Analysis of coordinated signaling networks maintaining tissue equilibrium

Research in this domain focuses on understanding how the combined peptide components of KLOW influence extracellular matrix dynamics, inflammatory signaling, and regenerative cellular pathways under controlled experimental conditions.

Laboratory Handling and Storage Protocols

Lyophilized Powder Storage

Store at –20°C to –80°C in the original, sealed vial
Protect from light exposure and moisture
A desiccated storage environment is recommended
Stability data suggests extended stability when stored at −20 °C or below.

Reconstitution Guidelines

Reconstitute using sterile water, bacteriostatic water (0.9% benzyl alcohol), or an appropriate laboratory buffer
Introduce solvent slowly along the vial wall to minimize foaming
Mix using gentle swirling; avoid vigorous agitation or shaking
Allow complete dissolution prior to use (typically 1–2 minutes)
Ensure the final solution is within a physiologically neutral pH range appropriate for laboratory use

Reconstituted Solution Storage

Short-term storage: Up to 7 days at 4°C
Long-term storage: Store at –20°C in aliquots
Use single-use aliquots to preserve peptide integrity
Minimize freeze–thaw cycles; single-use aliquots are strongly recommended

Stability Characteristics

KLOW is a multi-component peptide research blend containing GHK-Cu, BPC-157, TB-500, and KPV. As a composite formulation, overall stability depends on proper cold storage, protection from light, and minimized mechanical agitation during preparation. When handled according to standard peptide laboratory protocols, the blend maintains structural integrity and solubility suitable for in vitro and analytical research applications.

Frequently Asked Questions

What is KLOW?

KLOW is a research peptide blend combining:

GHK-Cu (copper-binding tripeptide complex)
BPC-157 (synthetic gastric peptide fragment)
TB-500 (Thymosin Beta-4 fragment)
KPV (Lys-Pro-Val tripeptide fragment)

It is formulated for laboratory investigation of combined peptide pathway interactions.

What is KLOW commonly researched for?

In preclinical and laboratory models, KLOW blends are studied for:

Extracellular matrix signaling research
Cellular migration and cytoskeletal pathway investigation
Inflammatory pathway modulation models
Tissue remodeling and regeneration signaling studies
Multi-peptide synergy research

All applications are exploratory and conducted in controlled research environments.

Why combine these peptides in a single blend?

Blended peptide formulations allow researchers to evaluate:

Potential synergistic pathway interactions
Complementary signaling mechanisms
Comparative effects versus individual peptide controls

This approach may reduce experimental complexity compared to running separate preparations in certain models.

Is KLOW a single peptide?

No. KLOW is a formulated multi-peptide blend, not a single amino acid sequence. Each component retains its own structural and signaling characteristics within the formulation.

How is KLOW supplied?

KLOW is typically supplied as a lyophilized (freeze-dried) powder blend in sealed research vials to maintain stability during storage and shipment.

How should unreconstituted KLOW be stored?

Lyophilized KLOW should be stored:

Long-term: −20 °C to −80 °C
Short-term: 2–8 °C

Keep vials sealed and protected from light and moisture until use.

How should reconstituted KLOW be handled and stored?

Once reconstituted:

Store at 2–8 °C for short-term laboratory use
For extended storage, aliquot and freeze at −20 °C or below
Minimize freeze–thaw cycles using single-use aliquots
Protect from prolonged light exposure (especially due to GHK-Cu)
Gently swirl to mix; avoid vigorous agitation

Does Kisspeptin-10 require a Certificate of Analysis (COA)?

Yes. A Certificate of Analysis (COA) should be available for each batch, verifying the identity and purity of each peptide component within the blend to ensure research quality and traceability.

Is KLOW FDA-approved?

No. KLOW is not FDA-approved as a drug, supplement, or therapeutic product. It is sold exclusively as a research compound blend and must not be marketed or used for diagnostic, therapeutic, or consumption purposes.

⚠️ Research Use Only

This product is not for human consumption. It is sold strictly for research and educational purposes and is not intended to diagnose, treat, cure, or prevent any disease.

Any clinical data or research information referenced on this page is derived from peer-reviewed scientific literature and official publications. This information is provided for educational reference only and does not constitute medical advice or product claims.

By purchasing this product, you acknowledge that you are a qualified researcher and agree to use it in full compliance with all applicable laws and regulations.