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Research Database / Peptides / SS-31
SS-31

SS-31

Cellular Research Compounds
Overview Research Publications Laboratory FAQ References
Overview
AbbreviationSS-31
CAS Number736992-21-5
Molecular formulaC32H49N9O5
Molecular weight639.8 g/mol (average)
PubChem CID11764719
2D / 3D structure
2D chemical structure of SS-31
Research Summary

Mechanisms under investigation

The following are areas of ongoing preclinical investigation. They describe hypotheses and observations reported in the literature, not established clinical effects.

Evidence tiers below reflect how much has been studied in each model type. Counts describe research volume — they do not indicate proven efficacy, safety, or clinical consensus.

Evidence base (transparent counts)

Cellular studies 0 publications
Animal studies 3 publications
Human observational reports 0 publications
Controlled human trials 0 publications
Review articles 1 publication
Publication Library

Selected literature

Filter by study model. Each record is classified for the evidence base above.

2025
Review summarizing the structure, proposed cardiolipin-binding mechanism of action, and investigational research directions for SS-31.Review · PubMed (39940712)
2023
Mechanistic study reporting that SS-31 altered ADP sensitivity in aged mitochondria via adenine nucleotide translocator uptake.Animal · mouse · PubMed (37462785)
2022
Controlled animal study reporting that SS-31 did not alter muscle atrophy measured seven days after contusion spinal cord injury in young male mice.Animal · mouse · PubMed (35611788)
2021
Preclinical study examining changes in age-associated post-translational modifications of cardiac proteins following SS-31 administration in aged mice.Animal · mouse · PubMed (34480713)

Each record maps to a structured evidence row with study model, species, and support level.

Laboratory Information

Handling and reference

Molecular weight calculator

Average-mass estimate from a one-letter sequence.

Reconstitution calculator

Laboratory concentration only. Not dosing guidance.

Frequently Asked Questions
What is SS-31?
SS-31 is a research compound; the identity and structure data shown here are compiled from public chemical databases (primarily PubChem). For laboratory research use only.
What research models has it been studied in?
The literature indexed here is predominantly cellular (in vitro) and animal studies. See the evidence base and publication library above for the transparent counts by study model.
Is there controlled human clinical trial evidence?
Controlled human clinical trials are counted separately in the evidence base above. Cellular and animal findings do not establish human clinical effects.
How is it stored and handled in a laboratory?
Refer to the laboratory information section above.
Is this intended for human use?
No. All information and materials are for laboratory research use only — not for human or veterinary use, and not intended to diagnose, treat, cure, or prevent any disease.
Documentation

Research material & documentation

This profile is an educational reference. Lot-level laboratory documentation for materials supplied by Peptide Titans is published openly.

SS-31 research material →  ·  Lot-specific Certificates of Analysis →  ·  How lots are tested →

References and Citation

Evidence records

  1. Review summarizing the structure, proposed cardiolipin-binding mechanism of action, and investigational research directions for SS-31. (2025) — review — PubMed.
  2. Mechanistic study reporting that SS-31 altered ADP sensitivity in aged mitochondria via adenine nucleotide translocator uptake. (2023) — in vivo — PubMed.
  3. Controlled animal study reporting that SS-31 did not alter muscle atrophy measured seven days after contusion spinal cord injury in young male mice. (2022) — in vivo — PubMed.
  4. Preclinical study examining changes in age-associated post-translational modifications of cardiac proteins following SS-31 administration in aged mice. (2021) — in vivo — PubMed.

Every record carries a study model, species, support level and review status in the evidence table. Terms used throughout these profiles are defined in the peptide research glossary.

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For laboratory research use only. Not for human or veterinary use. Educational reference information — not medical advice.