For laboratory research use only. Not for human or veterinary use. This is educational reference information, not medical advice.
Semax · Semax
Semax
Neuropeptides
| Scientific name | Semax |
|---|---|
| Synonyms | ACTH(4-7)-Pro-Gly-Pro |
| Abbreviation | Semax |
| CAS Number | 80714-61-0 |
| Molecular formula | C37H51N9O10S |
| Molecular weight | 813.9 g/mol (average) |
| Sequence (one-letter) | MEHFPGP |
| Length | 7 residues |
| PubChem CID | 9811102 |
2D / 3D structure
![2D chemical structure of Semax]()
Interactive sequence
Select a residue to see its amino acid.
Mechanisms under investigation
The following are areas of ongoing preclinical investigation. They describe hypotheses and observations reported in the literature, not established clinical effects.
Evidence tiers below reflect how much has been studied in each model type. Counts describe research volume — they do not indicate proven efficacy, safety, or clinical consensus.
Evidence base (transparent counts)
Cellular studies
1 publication
Animal studies
3 publications
Human observational reports
0 publications
Controlled human trials
0 publications
Review articles
0 publications
Selected literature
Filter by study model. Each record is classified for the evidence base above.
2025
Preclinical study in female mice examining semax effects on Oprm1-linked deubiquitination and functional recovery after spinal cord injury.Animal · mouse · PubMed (40692165)
2022
In vitro study examining how semax influences copper-induced amyloid-beta aggregation and amyloid formation in artificial membrane models.Cellular · PubMed (35080861)
2014
Genome-wide transcriptional analysis reporting semax-associated changes in immune- and vascular-related gene expression in a rat focal brain ischemia model.Animal · rat · PubMed (24661604)
2005
Rodent study reporting semax-associated activation of dopaminergic and serotoninergic brain systems.Animal · rodent (rat) · PubMed (16362768)
Each record maps to a structured evidence row with study model, species, and support level.
Handling and reference
Molecular weight calculator
Average-mass estimate from a one-letter sequence.
Reconstitution calculator
Laboratory concentration only. Not dosing guidance.
What is Semax?
Semax is a research compound; the identity and structure data shown here are compiled from public chemical databases (primarily PubChem). For laboratory research use only.
What research models has it been studied in?
The literature indexed here is predominantly cellular (in vitro) and animal studies. See the evidence base and publication library above for the transparent counts by study model.
Is there controlled human clinical trial evidence?
Controlled human clinical trials are counted separately in the evidence base above. Cellular and animal findings do not establish human clinical effects.
How is it stored and handled in a laboratory?
Refer to the laboratory information section above.
Is this intended for human use?
No. All information and materials are for laboratory research use only — not for human or veterinary use, and not intended to diagnose, treat, cure, or prevent any disease.
Research material & documentation
This profile is an educational reference. Lot-level laboratory documentation for materials supplied by Peptide Titans is published openly.
Semax research material → · Lot-specific Certificates of Analysis → · How lots are tested →
Evidence records
- Preclinical study in female mice examining semax effects on Oprm1-linked deubiquitination and functional recovery after spinal cord injury. (2025) — in vivo — PubMed.
- In vitro study examining how semax influences copper-induced amyloid-beta aggregation and amyloid formation in artificial membrane models. (2022) — in vitro — PubMed.
- Genome-wide transcriptional analysis reporting semax-associated changes in immune- and vascular-related gene expression in a rat focal brain ischemia model. (2014) — in vivo — PubMed.
- Rodent study reporting semax-associated activation of dopaminergic and serotoninergic brain systems. (2005) — in vivo — PubMed.
Every record carries a study model, species, support level and review status in the evidence table.
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For laboratory research use only. Not for human or veterinary use. Educational reference information — not medical advice.