Molecular Characteristics
Complete Specifications
Structural Composition
Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂
Physical Properties
SNAP-8 (Acetyl Octapeptide-3) is a synthetic octapeptide derived from a fragment of the SNAP-25 protein. N-terminal acetylation and C-terminal amidation enhance structural stability under research conditions. Its short chain length supports strong aqueous solubility and efficient laboratory handling. As with other small linear peptides, protection from moisture, light exposure, and repeated freeze–thaw cycles helps preserve structural integrity and maintain analytical consistency during laboratory applications.
Analysis & Documentation
Identity
Each production lot is checked against the reference structure recorded for this compound:
- Classification — Synthetic octapeptide (acetylated SNAP-25 fragment analog)
- Molecular formula — C₄₁H₇₀N₁₆O₁₆S
- Expected mass — ~1,075.2 Da
- CAS registry — 868844-74-0
- Chain length — 8 amino acids (N-acetylated, C-terminal amidated)
- PubChem CID — Not available
Analytical Methods
Testing is carried out per lot by an independent laboratory. The methods measure what the material is and how much of it is the target compound:
- RP-HPLC — reverse-phase separation of the target from process-related impurities; purity is reported as area percent of the main peak
- Mass spectrometry — observed mass compared against the expected molecular mass above
- Retention time — compared against a reference standard run under the same conditions
- Chromatogram — reproduced on the certificate so the peak and any shoulders can be inspected directly
Material & Documentation
What arrives, and how to tie it back to its paperwork:
- Appearance as supplied — White to off-white lyophilized powder
- Solubility — Water, buffered aqueous solutions (e.g., PBS)
- Lot number — printed on the container label and used to look up the certificate
- Certificate — indexed by lot at Certificates of Analysis
Laboratory Handling and Storage Protocols
Lyophilized Powder Storage
- Store at –20°C to –80°C in the original, sealed vial
- Protect from light exposure and moisture
- A desiccated storage environment is recommended
- Stability data suggests extended stability when stored at −20 °C or below.
Reconstituted Solution Storage
- Short-term storage: Up to 7 days at 4°C
- Long-term storage: Store at –20°C in aliquots
- Use single-use aliquots to preserve peptide integrity
- Minimize freeze–thaw cycles; single-use aliquots are strongly recommended
Stability Characteristics
SNAP-8 is a synthetic peptide research compound that demonstrates stable handling characteristics when managed according to standard peptide laboratory protocols. Proper cold storage of the lyophilized material, protection from light, careful reconstitution, and minimized freeze–thaw exposure help maintain structural integrity and solubility. When handled appropriately, SNAP-8 supports consistent use in in vitro and analytical research applications.
Frequently Asked Questions
What is SNAP-8?
SNAP-8 is a synthetic eight–amino acid peptide fragment modeled after a portion of the SNAP-25 protein. It is used in research to investigate vesicle fusion mechanisms and synaptic signaling pathways.
Is SNAP-8 a naturally occurring peptide?
No. SNAP-8 is a synthetically engineered fragment derived from a naturally occurring protein (SNAP-25), but it does not occur naturally in this isolated peptide form.
How does SNAP-8 differ from SNAP-25?
SNAP-25 is a full-length neuronal protein involved in vesicle fusion, whereas SNAP-8 is a short synthetic fragment designed to model and study specific regions of the protein in experimental systems.
How is SNAP-8 supplied?
SNAP-8 is typically supplied as a lyophilized (freeze-dried) powder in sealed research vials or as a stabilized compound for laboratory use.
How should unreconstituted SNAP-8 be stored?
Lyophilized SNAP-8 should be stored:
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Long-term: −20 °C to −80 °C
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Short-term: 2–8 °C
Keep vials sealed and protected from light and moisture until use.
How should reconstituted SNAP-8 be handled and stored?
Once reconstituted:
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Store at 2–8 °C for short-term laboratory use
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For extended storage, aliquot and freeze at −20 °C or below
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Minimize freeze–thaw cycles using single-use aliquots
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Gently swirl to mix; avoid vigorous agitation
Does SNAP-8 require a Certificate of Analysis (COA)?
Yes. A Certificate of Analysis (COA) should be available for each batch of SNAP-8, verifying identity, purity, and analytical testing results to ensure research quality and traceability.
Is SNAP-8 FDA-approved?
When sold as a research compound, SNAP-8 is not FDA-approved for diagnostic, therapeutic, or consumption purposes and must be marketed strictly for laboratory research use.
This product is not for human consumption. It is sold strictly for research and educational purposes and is not intended to diagnose, treat, cure, or prevent any disease.
Any clinical data or research information referenced on this page is derived from peer-reviewed scientific literature and official publications. This information is provided for educational reference only and does not constitute medical advice or product claims.
By purchasing this product, you acknowledge that you are a qualified researcher and agree to use it in full compliance with all applicable laws and regulations.
