Molecular Characteristics
Complete Specifications
Structural Composition
24-amino-acid MGF (IGF-1 Ec splice variant) peptide fragment conjugated to a polyethylene glycol (PEG) moiety
Physical Properties
PEG MGF is a modified 24-amino-acid peptide corresponding to the mechano growth factor (MGF), an IGF-1 Ec domain splice variant fragment, conjugated to a polyethylene glycol (PEG) chain. PEGylation increases molecular size and enhances resistance to enzymatic degradation under research conditions, contributing to improved structural persistence compared to non-PEGylated MGF. The overall molecular weight and formula depend on the PEG chain length and conjugation chemistry. Lyophilized storage and protection from moisture, light exposure, and repeated freeze–thaw cycles help maintain structural integrity and analytical consistency during laboratory applications.
Analysis & Documentation
Identity
Each production lot is checked against the reference structure recorded for this compound:
- Classification — PEGylated synthetic MGF (IGF-1 Ec domain) analog
- Molecular formula — Variable (peptide conjugated to polyethylene glycol chain)
- Expected mass — Variable (~2,800–5,000+ Da depending on PEG size)
- CAS registry — Not assigned (PEGylated peptide analog)
- Chain length — 24 amino acids (PEG-conjugated)
- PubChem CID — Not available
Analytical Methods
Testing is carried out per lot by an independent laboratory. The methods measure what the material is and how much of it is the target compound:
- RP-HPLC — reverse-phase separation of the target from process-related impurities; purity is reported as area percent of the main peak
- Mass spectrometry — observed mass compared against the expected molecular mass above
- Retention time — compared against a reference standard run under the same conditions
- Chromatogram — reproduced on the certificate so the peak and any shoulders can be inspected directly
Material & Documentation
What arrives, and how to tie it back to its paperwork:
- Appearance as supplied — White to off-white lyophilized powder (may appear slightly translucent due to PEG)
- Solubility — Water, buffered aqueous solutions (e.g., PBS)
- Lot number — printed on the container label and used to look up the certificate
- Certificate — indexed by lot at Certificates of Analysis
Laboratory Handling and Storage Protocols
Lyophilized Powder Storage
- Store at –20°C to –80°C in the original, sealed vial
- Protect from light exposure and moisture
- A desiccated storage environment is recommended
- Stability data suggests extended stability when stored at −20 °C or below.
Reconstituted Solution Storage
- Short-term storage: Up to 7 days at 4°C
- Long-term storage: Store at –20°C in aliquots
- Use single-use aliquots to preserve peptide integrity
- Minimize freeze–thaw cycles; single-use aliquots are strongly recommended
Stability Characteristics
PEG-MGF is a PEGylated synthetic peptide research compound designed for enhanced stability relative to non-PEGylated variants. Proper cold storage of the lyophilized material, careful solvent selection, and minimized freeze–thaw exposure help preserve molecular integrity and solubility. When handled according to standard peptide laboratory protocols, PEG-MGF supports consistent use in in vitro and analytical research applications.
Frequently Asked Questions
What is PEG MGF?
PEG MGF is a pegylated version of mechano growth factor, a peptide derived from an alternative splice variant of IGF-1. The pegylation process is used in research to improve peptide stability and prolong activity in experimental environments.
How does PEG MGF differ from standard MGF?
PEG MGF differs from standard MGF by the addition of a polyethylene glycol (PEG) chain, which may:
-
Increase molecular stability
-
Reduce enzymatic degradation
-
Extend activity duration in research models
Is PEG MGF the same as IGF-1 LR3?
No. While both relate to IGF-1 pathway research, PEG MGF and IGF-1 LR3 are structurally distinct compounds. PEG MGF is derived from the mechano growth factor splice variant, whereas IGF-1 LR3 is a modified full-length IGF-1 analog.
How is PEG MGF supplied?
PEG MGF is typically supplied as a lyophilized (freeze-dried) powder in sealed research vials to preserve stability during storage and shipment.
How should unreconstituted PEG MGF be stored?
Lyophilized PEG MGF should be stored:
-
Long-term: −20 °C to −80 °C
-
Short-term: 2–8 °C
Keep vials sealed and protected from light and moisture until use.
How should reconstituted PEG MGF be handled and stored?
Once reconstituted:
-
Store at 2–8 °C for short-term laboratory use
-
For extended storage, aliquot and freeze at −20 °C or below
-
Minimize freeze–thaw cycles using single-use aliquots
-
Gently swirl to mix; avoid vigorous agitation
Does PEG MGF require a Certificate of Analysis (COA)?
Yes. A Certificate of Analysis (COA) should be available for each batch of PEG MGF, verifying identity, purity, and analytical testing results to ensure research quality and traceability.
Is PEG MGF FDA-approved?
No. PEG MGF is not FDA-approved as a drug, supplement, or therapeutic product. It is sold exclusively as a research compound and must not be marketed or used for diagnostic, therapeutic, or consumption purposes.
This product is not for human consumption. It is sold strictly for research and educational purposes and is not intended to diagnose, treat, cure, or prevent any disease.
Any clinical data or research information referenced on this page is derived from peer-reviewed scientific literature and official publications. This information is provided for educational reference only and does not constitute medical advice or product claims.
By purchasing this product, you acknowledge that you are a qualified researcher and agree to use it in full compliance with all applicable laws and regulations.
