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GLP-2(T)

Price range: $229.99 through $594.99

GLP-2(T) is a synthetic dual-receptor agonist studied for its activity at GLP-1 and GIP receptors, targeting metabolic and incretin-related signaling pathways. In research settings, it’s explored for its potential influence on glucose regulation, appetite modulation, and energy balance mechanisms through multi-hormonal pathway interaction. Intended for research use only, not for human or veterinary use.

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Description
Additional information

Molecular Characteristics

Complete Specifications

CAS Registry Number: 2023788-19-2
PubChem CID: Not available
Peptide Classification: Synthetic dual agonist peptide (GIP / GLP-1 receptor analog)
Molecular Formula: C₂₂₅H₃₄₈N₄₈O₆₈
Molecular Weight: ~4,813.5 Da

Structural Composition

Amino Acid Sequence:
39-amino-acid modified incretin peptide with targeted amino acid substitutions and C20 fatty-diacid side-chain conjugation
Length: 39 amino acids (lipidated)

Physical Properties

Appearance: White to off-white lyophilized powder
Solubility: Water, bacteriostatic water, buffered aqueous solutions (e.g., PBS)

Structural & Stability Notes

GLP-2(T) is a modified 39-amino-acid peptide engineered as a dual GIP and GLP-1 receptor agonist. Targeted amino acid substitutions enhance receptor activity and resistance to enzymatic degradation under research conditions. Conjugation to a C20 fatty-diacid side chain supports reversible binding to circulating proteins, increasing molecular size and structural persistence compared to non-lipidated peptides. Lyophilized storage and protection from moisture, light exposure, and repeated freeze–thaw cycles help preserve structural integrity and analytical consistency during laboratory applications.

Research Applications

Dual Incretin Receptor Signaling Research

GLP-2(T) is utilized as a dual receptor agonist in research studies examining glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor–associated signaling pathways. Laboratory investigations focus on its role in:

GLP-1 Receptor Activation Models: Investigation of receptor binding dynamics and intracellular cAMP-mediated cascades
GIP Receptor Signaling Studies: Evaluation of incretin-associated intracellular pathways influencing metabolic regulation
Second Messenger Amplification Research: Analysis of adenylate cyclase activation and protein kinase A (PKA) signaling
Receptor Internalization Models: Examination of adaptive responsiveness and signaling duration following dual activation
Peptide Stability Studies: Investigation of structural persistence and receptor selectivity in laboratory systems

Experimental protocols commonly employ receptor-binding assays, intracellular kinase activation analyses, and metabolic cell culture models to characterize GLP-2(T)–mediated signaling responses.

Metabolic Regulation and Glucose Signaling Research

GLP-2(T) has been examined in research contexts involving coordinated incretin signaling and systemic metabolic regulation models. Key areas of investigation include:

Pancreatic Beta-Cell Signaling Models: Evaluation of intracellular cascades associated with insulin-related pathways
Glucose Transport Regulation Studies: Investigation of signaling pathways influencing cellular glucose uptake mechanisms
Appetite-Associated Circuit Research: Analysis of hypothalamic signaling pathways under controlled laboratory conditions
Adipocyte Signaling Models: Research into coordinated pathways influencing lipid-associated intracellular regulation
Energy Balance Studies: Examination of integrated signaling systems governing substrate utilization models

These studies utilize metabolic profiling assays, hormone quantification systems, and intracellular signaling analyses to evaluate incretin-associated regulatory outcomes.

Hepatic and Lipid Metabolism Research

GLP-2(T) has also been explored in research models examining hepatic signaling and lipid-associated metabolic regulation, including:

Hepatocyte Signaling Studies: Evaluation of intracellular cascades regulating glucose and fatty acid metabolism
AMPK Pathway Models: Investigation of energy-sensing signaling mechanisms
Lipid Mobilization Research: Analysis of regulatory pathways influencing substrate utilization
Metabolic Stress Adaptation Studies: Examination of coordinated cellular responses to energy fluctuation models

Laboratory protocols assess enzyme activity markers, transcriptional profiling, and intracellular kinase activation using biochemical and molecular techniques.

Cellular Signaling and Incretin Network Research

Additional research applications explore GLP-2(T)’s influence on intracellular regulatory systems involved in coordinated GLP-1 and GIP receptor networks, including:

MAPK and ERK Pathway Studies: Investigation of downstream cascades associated with dual receptor activation
Gene Expression Profiling: Analysis of transcriptional responses linked to incretin-mediated signaling
Receptor Sensitivity Research: Examination of adaptive signaling modulation across GLP-1 and GIP receptor systems
Integrated Endocrine Feedback Models: Analysis of coordinated hormonal signaling maintaining metabolic equilibrium

Research in this domain focuses on understanding how GLP-2(T) influences GLP-1 and GIP receptor–mediated signaling pathways, systemic metabolic regulatory networks, and adaptive cellular responses under controlled experimental conditions.

Laboratory Handling and Storage Protocols

Lyophilized Powder Storage

Store at –20°C to –80°C in the original, sealed vial
Protect from light exposure and moisture
A desiccated storage environment is recommended
Stability data suggests extended stability when stored at −20 °C or below.

Reconstitution Guidelines

Reconstitute using sterile water, bacteriostatic water (0.9% benzyl alcohol), or an appropriate laboratory buffer
Introduce solvent slowly along the vial wall to minimize foaming
Mix using gentle swirling; avoid vigorous agitation or shaking
Allow complete dissolution prior to use (typically 1–2 minutes)
Target a final solution pH of 7.0–8.0 for optimal stability

Reconstituted Solution Storage

Short-term storage: Up to 7 days at 4°C
Long-term storage: Store at –20°C in aliquots
Use single-use aliquots to preserve peptide integrity
Minimize freeze–thaw cycles; single-use aliquots are strongly recommended

Stability Characteristics

GLP-2(T) is a synthetic modified multi-receptor peptide research compound designed with extended structural features. Stability depends on proper cold storage of the lyophilized material, protection from light, careful reconstitution, and minimized freeze–thaw exposure. When handled according to standard peptide laboratory protocols, GLP-2(T) maintains structural integrity and solubility suitable for in vitro and analytical research applications.

Frequently Asked Questions

What is GLP-2(T)?

GLP-2(T) is a synthetic dual agonist peptide designed to interact with GLP-1 and GIP receptors for the study of coordinated metabolic signaling pathways.

What is GLP-2(T) commonly researched for?

In laboratory and preclinical models, GLP-2(T) is studied for:

GLP-1 receptor signaling mechanisms
GIP receptor activation research
Dual incretin pathway investigations
Metabolic and endocrine signaling models
Multi-receptor agonist pathway analysis

All applications are exploratory and conducted in controlled research environments.

How does GLP-2(T) differ from single-receptor GLP-1 analogs?

Unlike compounds that selectively activate only the GLP-1 receptor, GLP-2(T) is studied as a dual agonist, targeting both GLP-1 and GIP receptors in experimental models. This enables investigation of integrated incretin pathway interactions.

How does GLP-2(T) differ from GLP-3(R) (Retatrutide)?

GLP-2(T) is a dual GLP-1/GIP receptor agonist, whereas GLP-3(R) (Retatrutide) is studied as a triple agonist targeting GLP-1, GIP, and glucagon receptors. Their receptor interaction profiles differ in research models.

Is GLP-2(T) a peptide?

Yes. GLP-2(T) is a synthetic peptide analog developed for receptor-targeted metabolic research.

How is GLP-2(T) supplied?

GLP-2(T) is typically supplied as a lyophilized (freeze-dried) powder in sealed research vials to maintain stability during storage and shipment.

How should unreconstituted GLP-2(T) be stored?

Lyophilized GLP-2(T) should be stored:

Long-term: −20 °C to −80 °C
Short-term: 2–8 °C

Keep vials sealed and protected from light and moisture until use.

How should reconstituted GLP-2(T) be handled and stored?

Once reconstituted:

Store at 2–8 °C for short-term laboratory use
For extended storage, aliquot and freeze at −20 °C or below
Minimize freeze–thaw cycles using single-use aliquots
Gently swirl to mix; avoid vigorous agitation

Does GLP-3(R) require a Certificate of Analysis (COA)?

Yes. A Certificate of Analysis (COA) should be available for each batch, verifying peptide identity, purity, and analytical testing results to ensure research quality and traceability.

Is GLP-2(T) FDA-approved?

When sold as a research compound, GLP-2(T) is not FDA-approved for diagnostic, therapeutic, or consumption purposes and must be marketed strictly for laboratory research use.

⚠️ Research Use Only

This product is not for human consumption. It is sold strictly for research and educational purposes and is not intended to diagnose, treat, cure, or prevent any disease.

Any clinical data or research information referenced on this page is derived from peer-reviewed scientific literature and official publications. This information is provided for educational reference only and does not constitute medical advice or product claims.

By purchasing this product, you acknowledge that you are a qualified researcher and agree to use it in full compliance with all applicable laws and regulations.