For laboratory research use only. Not for human or veterinary use. This is educational reference information, not medical advice.
Research Database / Peptides / Kisspeptin-10
KP-10 · Metastin 45-54

Kisspeptin-10

Metabolics
Overview Research Publications Laboratory FAQ References
Overview
Scientific nameMetastin 45-54
AbbreviationKP-10
CAS Number374675-21-5
Molecular formulaC63H83N17O14
Molecular weight1302.4 g/mol (average)
PubChem CID25240297
2D / 3D structure
2D chemical structure of Kisspeptin-10
Research Summary

Mechanisms under investigation

The following are areas of ongoing preclinical investigation. They describe hypotheses and observations reported in the literature, not established clinical effects.

Evidence tiers below reflect how much has been studied in each model type. Counts describe research volume — they do not indicate proven efficacy, safety, or clinical consensus.

Evidence base (transparent counts)

Cellular studies 2 publications
Animal studies 3 publications
Human observational reports 0 publications
Controlled human trials 0 publications
Review articles 1 publication
Publication Library

Selected literature

Filter by study model. Each record is classified for the evidence base above.

2024
Mouse and osteoclast study examining kisspeptin-10 binding to Gpr54 and a Dusp18/Src dephosphorylation pathway in relation to bone loss.Animal · mouse · PubMed (38346942)
2022
In vitro study reporting effects of kisspeptin-10 on cholinergic differentiated SH-SY5Y cells exposed to alpha-synuclein-induced toxicity.Cellular · PubMed (35563582)
2014
Electrophysiological study in rat supraoptic nucleus reporting that kisspeptin-10 application altered miniature excitatory postsynaptic current activity.Animal · rat · PubMed (25130664)
2014
In vitro study reporting that kisspeptin-10 exposure induced markers of cellular senescence and reduced growth in endothelial cells.Cellular · PubMed (24405415)
2010
Comparative rodent study characterizing the in vivo bioactivity and gonadotropin-releasing effects of kisspeptin-10 relative to a modified analog.Animal · rat · PubMed (19934405)
2006
Review of the kisspeptin/GPR54 signalling system, including the kisspeptin-10 decapeptide, and its described role in reproductive neuroendocrine regulation.Review · PubMed (16731583)

Each record maps to a structured evidence row with study model, species, and support level.

Laboratory Information

Handling and reference

Molecular weight calculator

Average-mass estimate from a one-letter sequence.

Reconstitution calculator

Laboratory concentration only. Not dosing guidance.

Frequently Asked Questions
What is Kisspeptin-10?
Kisspeptin-10 is a research compound; the identity and structure data shown here are compiled from public chemical databases (primarily PubChem). For laboratory research use only.
What research models has it been studied in?
The literature indexed here is predominantly cellular (in vitro) and animal studies. See the evidence base and publication library above for the transparent counts by study model.
Is there controlled human clinical trial evidence?
Controlled human clinical trials are counted separately in the evidence base above. Cellular and animal findings do not establish human clinical effects.
How is it stored and handled in a laboratory?
Refer to the laboratory information section above.
Is this intended for human use?
No. All information and materials are for laboratory research use only — not for human or veterinary use, and not intended to diagnose, treat, cure, or prevent any disease.
Documentation

Research material & documentation

This profile is an educational reference. Lot-level laboratory documentation for materials supplied by Peptide Titans is published openly.

Kisspeptin-10 research material →  ·  Lot-specific Certificates of Analysis →  ·  How lots are tested →

References and Citation

Evidence records

  1. Mouse and osteoclast study examining kisspeptin-10 binding to Gpr54 and a Dusp18/Src dephosphorylation pathway in relation to bone loss. (2024) — in vivo — PubMed.
  2. In vitro study reporting effects of kisspeptin-10 on cholinergic differentiated SH-SY5Y cells exposed to alpha-synuclein-induced toxicity. (2022) — in vitro — PubMed.
  3. Electrophysiological study in rat supraoptic nucleus reporting that kisspeptin-10 application altered miniature excitatory postsynaptic current activity. (2014) — in vivo — PubMed.
  4. In vitro study reporting that kisspeptin-10 exposure induced markers of cellular senescence and reduced growth in endothelial cells. (2014) — in vitro — PubMed.
  5. Comparative rodent study characterizing the in vivo bioactivity and gonadotropin-releasing effects of kisspeptin-10 relative to a modified analog. (2010) — in vivo — PubMed.
  6. Review of the kisspeptin/GPR54 signalling system, including the kisspeptin-10 decapeptide, and its described role in reproductive neuroendocrine regulation. (2006) — review — PubMed.

Every record carries a study model, species, support level and review status in the evidence table.

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For laboratory research use only. Not for human or veterinary use. Educational reference information — not medical advice.