For laboratory research use only. Not for human or veterinary use. This is educational reference information, not medical advice.
Research Database / Peptides / MOTS-c
MOTS-c · Mitochondrial-derived peptide MOTS-c

MOTS-c

Cellular Research Compounds
Overview Research Publications Laboratory FAQ References
Overview
Scientific nameMitochondrial-derived peptide MOTS-c
AbbreviationMOTS-c
CAS Number1627580-64-6
Molecular formulaC101H152N28O22S2
Molecular weight2174.6 g/mol (average)
Sequence (one-letter)MRWQEMGYIFYPRKLR
Length16 residues
PubChem CID146675088
2D / 3D structure
2D chemical structure of MOTS-c

Interactive sequence

Select a residue to see its amino acid.
Research Summary

Mechanisms under investigation

The following are areas of ongoing preclinical investigation. They describe hypotheses and observations reported in the literature, not established clinical effects.

Evidence tiers below reflect how much has been studied in each model type. Counts describe research volume — they do not indicate proven efficacy, safety, or clinical consensus.

Evidence base (transparent counts)

Cellular studies 1 publication
Animal studies 2 publications
Human observational reports 0 publications
Controlled human trials 0 publications
Review articles 2 publications
Publication Library

Selected literature

Filter by study model. Each record is classified for the evidence base above.

2023
Review summarizing the biology of the mitochondrial-derived peptide MOTS-c and the preclinical literature on its metabolic signaling roles.Review · PubMed (36761202)
2022
Preclinical study examining MOTS-c administration and glucose handling in a gestational diabetes mellitus model.Animal · mouse · PubMed (34798268)
2018
Cell-based study reporting nuclear translocation of MOTS-c and associated changes in nuclear gene expression under metabolic stress.Cellular · PubMed (29983246)
2016
Review describing reported actions of MOTS-c on skeletal muscle and adipose tissue metabolism in experimental models.Review · PubMed (27216708)
2015
Study identifying MOTS-c and examining its effects on metabolic parameters, including diet-induced obesity and insulin sensitivity, in mice.Animal · mouse · PubMed (25738459)

Each record maps to a structured evidence row with study model, species, and support level.

Laboratory Information

Handling and reference

Molecular weight calculator

Average-mass estimate from a one-letter sequence.

Reconstitution calculator

Laboratory concentration only. Not dosing guidance.

Frequently Asked Questions
What is MOTS-c?
MOTS-c is a research compound; the identity and structure data shown here are compiled from public chemical databases (primarily PubChem). For laboratory research use only.
What research models has it been studied in?
The literature indexed here is predominantly cellular (in vitro) and animal studies. See the evidence base and publication library above for the transparent counts by study model.
Is there controlled human clinical trial evidence?
Controlled human clinical trials are counted separately in the evidence base above. Cellular and animal findings do not establish human clinical effects.
How is it stored and handled in a laboratory?
Refer to the laboratory information section above.
Is this intended for human use?
No. All information and materials are for laboratory research use only — not for human or veterinary use, and not intended to diagnose, treat, cure, or prevent any disease.
Documentation

Research material & documentation

This profile is an educational reference. Lot-level laboratory documentation for materials supplied by Peptide Titans is published openly.

MOTS-c research material →  ·  Lot-specific Certificates of Analysis →  ·  How lots are tested →

References and Citation

Evidence records

  1. Review summarizing the biology of the mitochondrial-derived peptide MOTS-c and the preclinical literature on its metabolic signaling roles. (2023) — review — PubMed.
  2. Preclinical study examining MOTS-c administration and glucose handling in a gestational diabetes mellitus model. (2022) — in vivo — PubMed.
  3. Cell-based study reporting nuclear translocation of MOTS-c and associated changes in nuclear gene expression under metabolic stress. (2018) — in vitro — PubMed.
  4. Review describing reported actions of MOTS-c on skeletal muscle and adipose tissue metabolism in experimental models. (2016) — review — PubMed.
  5. Study identifying MOTS-c and examining its effects on metabolic parameters, including diet-induced obesity and insulin sensitivity, in mice. (2015) — in vivo — PubMed.

Every record carries a study model, species, support level and review status in the evidence table.

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For laboratory research use only. Not for human or veterinary use. Educational reference information — not medical advice.