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Melanotan II

Name: Melanotan II
Brand: Peptide Titans
SKU: 550
Availability: InStock

Original price was: $239.99.Current price is: $199.99.

Melanotan II is a synthetic analog of alpha-melanocyte–stimulating hormone (α-MSH) studied for its activity at multiple melanocortin receptors (MC1R, MC3R, MC4R, MC5R). In research settings, it’s explored for its role in melanin production, pigmentation pathways, and melanocortin-related signaling mechanisms. Intended for research use only, not for human or veterinary use.

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Molecular Characteristics

Complete Specifications

CAS Registry Number: 121062-08-6
PubChem CID: Not available
Peptide Classification: Synthetic cyclic α-MSH analog (melanocortin receptor agonist peptide)
Molecular Formula: C₅₀H₆₉N₁₅O₉
Molecular Weight: ~1,024.2 Da

Structural Composition

Amino Acid Sequence:
Ac-Nle-cyclo(Asp-His-D-Phe-Arg-Trp-Lys)-NH₂
Length: 7 amino acids (cyclic, modified)

Physical Properties

Appearance: White to off-white lyophilized powder
Solubility: Water, bacteriostatic water, buffered aqueous solutions (e.g., PBS)

Structural & Stability Notes

Melanotan II is a synthetic cyclic peptide analog of alpha-melanocyte-stimulating hormone (α-MSH). Cyclization between aspartic acid and lysine residues enhances conformational stability and resistance to enzymatic degradation compared to linear analogs. Additional modifications including norleucine substitution and D-phenylalanine incorporation contribute to structural persistence under controlled research conditions. Lyophilized storage and protection from moisture, light exposure, and repeated freeze–thaw cycles help preserve peptide integrity and maintain analytical consistency during laboratory applications.

Research Applications

Melanocortin Receptor Signaling Research

Melanotan II is utilized as a synthetic melanocortin analog in research studies examining melanocortin receptor activation and downstream intracellular signaling pathways. Laboratory investigations focus on its role in:

MC1R and MC4R Activation Models: Investigation of receptor binding dynamics and subtype selectivity profiles
cAMP Signaling Studies: Evaluation of cyclic AMP–mediated intracellular cascades following receptor stimulation
Receptor Interaction Research: Analysis of melanocortin receptor subtype cross-activation under experimental conditions
Second Messenger Pathway Models: Examination of protein kinase A (PKA) activation mechanisms
Receptor Desensitization Studies: Investigation of adaptive responsiveness following repeated stimulation

Experimental protocols commonly employ receptor-binding assays, melanocyte culture systems, and intracellular signaling analyses to characterize Melanotan II–mediated melanocortin responses.

Pigmentation and Melanocyte Biology Research

Melanotan II has been extensively studied in research models examining melanogenesis and pigment-related cellular pathways. Key areas of investigation include:

Melanin Synthesis Models: Evaluation of tyrosinase activity and pigment production signaling
Melanosome Formation Studies: Investigation of organelle maturation and pigment transport processes
Photobiology Research Models: Analysis of melanocortin signaling interactions in UV-associated experimental systems
Gene Expression Profiling: Research into transcriptional regulation of pigmentation-associated genes
Pigment Distribution Studies: Examination of intracellular mechanisms influencing melanin dispersion

These studies utilize melanocyte cultures, enzyme activity assays, and gene expression analyses to evaluate pigmentation-related signaling dynamics.

Neuroendocrine and Appetite Signaling Research

Melanotan II has also been explored in research models examining central melanocortin system signaling and neuroendocrine regulation, including:

MC4R Activation Studies: Evaluation of central receptor pathways involved in energy intake signaling
Hypothalamic Signaling Models: Investigation of neural circuits associated with melanocortin pathway activation
Neurotransmitter Interaction Research: Analysis of signaling cross-talk within central regulatory systems
Receptor Selectivity Profiling: Examination of subtype activation characteristics under experimental conditions

Laboratory protocols assess neuronal activation markers, receptor binding kinetics, and downstream transcriptional responses using biochemical and molecular techniques.

Cellular Signaling and Regulatory Pathway Research

Additional research applications explore Melanotan II’s influence on intracellular regulatory systems involved in melanocortin pathway modulation and cellular homeostasis, including:

MAPK and CREB Pathway Studies: Investigation of transcriptional activation cascades following receptor stimulation
Gene Expression Profiling: Analysis of melanocortin-associated transcription factor activity
Signal Duration and Potency Research: Examination of intracellular response kinetics
Integrated Melanocortin Network Models: Analysis of coordinated receptor interactions maintaining pathway equilibrium

Research in this domain focuses on understanding how Melanotan II influences melanocortin receptor signaling, pigmentation pathways, and neuroendocrine regulatory systems under controlled experimental conditions.

Laboratory Handling and Storage Protocols

Lyophilized Powder Storage

Store at –20°C to –80°C in the original, sealed vial
Protect from light exposure and moisture
A desiccated storage environment is recommended
Stability data suggests extended stability when stored at −20 °C or below.

Reconstitution Guidelines

Reconstitute using sterile water, bacteriostatic water (0.9% benzyl alcohol), or an appropriate laboratory buffer
Introduce solvent slowly along the vial wall to minimize foaming
Mix using gentle swirling; avoid vigorous agitation or shaking
Allow complete dissolution prior to use (typically 1–2 minutes)
Ensure the final solution is within a physiologically neutral pH range appropriate for laboratory use

Reconstituted Solution Storage

Short-term storage: Up to 7 days at 4°C
Long-term storage: Store at –20°C in aliquots
Use single-use aliquots to preserve peptide integrity
Minimize freeze–thaw cycles; single-use aliquots are strongly recommended

Stability Characteristics

Melanotan II is a synthetic peptide research compound that demonstrates stable handling characteristics when managed according to standard peptide laboratory protocols. Proper cold storage of the lyophilized material, protection from light, careful reconstitution, and minimized freeze–thaw exposure help preserve structural integrity and solubility. When handled appropriately, Melanotan II supports consistent use in in vitro and analytical research applications.

Frequently Asked Questions

What is Melanotan II?

Melanotan II is a synthetic peptide analog of α-MSH engineered to interact with melanocortin receptors in experimental models. It is commonly used in research exploring melanocortin receptor signaling mechanisms.

What is Melanotan II commonly researched for?

In laboratory and preclinical models, Melanotan II is studied for:

Melanocortin receptor activation (MC1R, MC3R, MC4R, etc.)
Melanogenesis pathway research
Pigmentation signaling mechanisms
Neuroendocrine melanocortin system investigations

All applications are exploratory and conducted in controlled research environments.

How does Melanotan II differ from Melanotan I?

Melanotan II is structurally distinct from Melanotan I and is a cyclic peptide, which may influence receptor binding characteristics and stability in research models. The two compounds differ in receptor selectivity and signaling profiles.

Is Melanotan II naturally occurring?

No. Melanotan II is a synthetically engineered analog and does not occur naturally in biological systems. It is designed to mimic and modify aspects of α-MSH signaling for research purposes.

How is Melanotan II supplied?

Melanotan II is typically supplied as a lyophilized (freeze-dried) powder in sealed research vials to preserve stability during storage and shipment.

How should unreconstituted Melanotan II be stored?

Lyophilized Melanotan II should be stored:

Long-term: −20 °C to −80 °C
Short-term: 2–8 °C

Keep vials sealed and protected from light and moisture until use.

How should reconstituted Melanotan II be handled and stored?

Once reconstituted:

Store at 2–8 °C for short-term laboratory use
For extended storage, aliquot and freeze at −20 °C or below
Minimize freeze–thaw cycles using single-use aliquots
Gently swirl to mix; avoid vigorous agitation

Does Melanotan II require a Certificate of Analysis (COA)?

Yes. A Certificate of Analysis (COA) should be available for each batch, verifying the identity and purity of each peptide component within the blend to ensure research quality and traceability.

Is Melanotan II FDA-approved?

No. Melanotan II is not FDA-approved as a drug, supplement, or therapeutic product. It is sold exclusively as a research compound and must not be marketed or used for diagnostic, therapeutic, or consumption purposes.

⚠️ Research Use Only

This product is not for human consumption. It is sold strictly for research and educational purposes and is not intended to diagnose, treat, cure, or prevent any disease.

Any clinical data or research information referenced on this page is derived from peer-reviewed scientific literature and official publications. This information is provided for educational reference only and does not constitute medical advice or product claims.

By purchasing this product, you acknowledge that you are a qualified researcher and agree to use it in full compliance with all applicable laws and regulations.